Intussusception in the setting of severe acute respiratory syndrome coronavirus 2 infection following rotavirus vaccination

Abstract

Most cases of intussusception are thought to be idiopathic, related to viral infections, structural abnormalities, or certain vaccinations. In this report, we present the development of intussusception in a pediatric patient who was coronavirus 2019 (COVID‐19) positive. Although the most common gastrointestinal symptoms of COVID‐19 virus are diarrhea and vomiting, there recently have been rare case reports of intussusception in patients throughout the world who are severe acute respiratory syndrome coronavirus 2 positive. This case is only the second known report in the United States and the second case reported globally that required surgical intervention for definitive management.

Intussusception and COVID-19 in Children: A Systematic Review and Meta-Analysis

“…Subsequently, 103 articles remained, which were analyzed in full text. In total, 34 studies met our inclusion criteria and reported SARS-CoV-2 infection in pediatric patients with ISN and were included for systematic review and meta-analysis [ 4 , 5 , 6 , 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. The detailed characteristics of the included studies are shown in Table 1 .…”

“…The detailed characteristics of the included studies are shown in Table 1 . There were 28 case report [ 4 , 6 , 7 , 15 , 16 , 17 , 18 , 19 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], 5 cohort [ 20 , 34 , 42 , 43 , 44 ] and 1 case-series [ 5 ] studies. These studies were conducted in United States (n = 9), Italy (n = 4), United Kingdom (n = 3), China (n = 3), India (n = 3), Iran (n = 2), Colombia (n = 2), Jordan (n = 1), Peru (n = 1), Hungary (n = 1), Guatemala (n = 1), Spain (n = 1), Mexico (n = 1), Pakistan (n = 1), and Turkey (n = 1).…”

“…These studies were conducted in United States (n = 9), Italy (n = 4), United Kingdom (n = 3), China (n = 3), India (n = 3), Iran (n = 2), Colombia (n = 2), Jordan (n = 1), Peru (n = 1), Hungary (n = 1), Guatemala (n = 1), Spain (n = 1), Mexico (n = 1), Pakistan (n = 1), and Turkey (n = 1). The majority of the studies were single center [ 4 , 5 , 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 37 , 38 , 39 , 40 , 41 , 43 , 44 ], and only four studies were multicenter [ 6 , 28 , 36 , 42 ]. Among the 34 included studies, 5 cohort studies were assessed using the NOS: 4 studies were found to be moderate-quality studies (i.e., NOS scores between 5 and 7) and 1 study demonstrated a relatively high quality (i.e., NOS scores > 7).…”

“…The median patient age ranged from 1 to 132 months across the studies. Most of the patients were in the 1-12 months age group (n = 32, 50%), p = 0.001 [ 4 , 5 , 6 , 7 , 15 , 16 , 17 , 18 , 20 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 35 , 36 , 38 , 39 , 40 , 41 , 43 ]. There was an increased male predominance in ISN patients diagnosed with SARS-CoV-2 in most of the studies (n = 41, 64.1%, p = 0.000) [ 4 , 7 , 15 , 16 , 17 , 19 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 42 ], and the majority of the patients belonged to White (Caucasian) (n = 25, 39.1%), Hispanic (n = 13, 20.3%) and Asian (n = 5, 7.8%) ethnicity, p = 0....…”

“…There was an increased male predominance in ISN patients diagnosed with SARS-CoV-2 in most of the studies (n = 41, 64.1%, p = 0.000) [ 4 , 7 , 15 , 16 , 17 , 19 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 36 , 37 , 38 , 39 , 40 , 42 ], and the majority of the patients belonged to White (Caucasian) (n = 25, 39.1%), Hispanic (n = 13, 20.3%) and Asian (n = 5, 7.8%) ethnicity, p = 0.000 [ 4 , 5 , 6 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 30 , 31 , 32 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. The reported ISN classification by location were mostly ileocolic (n = 35, 54.7%) [ ...…”