2024
DOI: 10.1002/brb3.3387
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Inulin alters gut microbiota to alleviate post‐stroke depressive‐like behavior associated with the IGF‐1‐mediated MAPK signaling pathway

Rong Shao,
Xiongchang Tan,
Minfu Pan
et al.

Abstract: IntroductionGut microbiota dysbiosis is a key factor of the pathogenesis of post‐stroke depression (PSD). PSD is associated with increased hippocampal neuronal apoptosis and decreased synaptic connectivity. Inulin can be involved in hippocampal neuron protection through the microbiome–gut–brain axis. However, the neuroprotective effects of inulin in PSD are still to be further investigated.MethodsBy utilizing the GEO public database, we identify differentially expressed genes in the hippocampus following inuli… Show more

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