Inulin ameliorates schizophrenia <i>via</i> modulation of the gut microbiota and anti-inflammation in mice

Xiao, Peilun; Zhang, Xiaoxia; Yang, Yang; Yang, Miao; Wang, Ting; Lü, Haixia; Tian, Hongyan; Wang, Hao; Liu, Juan

doi:10.1039/d0fo02778b

Cited by 46 publications

(26 citation statements)

References 79 publications

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“…On the other hand, it was pointed out how probiotics showed no clinical utility in both negative or positive symptoms, albeit only three studies were fully reviewed [ 168 ]. Interestingly, in a murine model, inulin, which is a dietary fibre mainly produced by plants [ 169 ], was also proposed as a potential treatment in SZ patients due to its anti-inflammatory action and the effects exerted on the gut microbiota [ 170 ].…”

Section: Microbiota and Psychiatric Disordersmentioning

confidence: 99%

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

Marazziti

Palermo

Parra

et al. 2021

Life

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The functioning of the central nervous system (CNS) is the result of the constant integration of bidirectional messages between the brain and peripheral organs, together with their connections with the environment. Despite the anatomical separation, gut microbiota, i.e., the microorganisms colonising the gastrointestinal tract, is highly related to the CNS through the so-called “gut–brain axis”. The aim of this paper was to review and comment on the current literature on the role of the intestinal microbiota and the gut–brain axis in some common neuropsychiatric conditions. The recent literature indicates that the gut microbiota may affect brain functions through endocrine and metabolic pathways, antibody production and the enteric network while supporting its possible role in the onset and maintenance of several neuropsychiatric disorders, neurodevelopment and neurodegenerative disorders. Alterations in the gut microbiota composition were observed in mood disorders and autism spectrum disorders and, apparently to a lesser extent, even in obsessive-compulsive disorder (OCD) and related conditions, as well as in schizophrenia. Therefore, gut microbiota might represent an interesting field of research for a better understanding of the pathophysiology of common neuropsychiatric disorders and possibly as a target for the development of innovative treatments that some authors have already labelled “psychobiotics”.

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Section: Microbiota and Psychiatric Disordersmentioning

confidence: 99%

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

Marazziti

Palermo

Parra

et al. 2021

Life

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“…Based on the resent findings that mastitis was linked to the alterations in gastrointestinal microbiota and metabolites ( Ma et al, 2018a ; Zhong et al, 2018 ; Hu et al, 2020 ; Wang et al, 2021b ), dietary intervention to remodeling the profile of microflora appeared to be a potential strategy in preventing mastitis. Inulin was extensively reported as the “food” of probiotics in the gastrointestinal tract ( Shoaib et al, 2016 ; Guo et al, 2021 ). In the current study, dietary inulin supplementation affected the profile of fecal microbiota in the SCM cows.…”

Section: Discussionmentioning

confidence: 99%

Changes in the Profile of Fecal Microbiota and Metabolites as Well as Serum Metabolites and Proteome After Dietary Inulin Supplementation in Dairy Cows With Subclinical Mastitis

et al. 2022

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“…Most likely, dietary fiber stimulates affective and cognitive processes through its interaction with the gut microbiome [ 100 ]. The gut microbial modulation effect of inulin (fructan) on mice with SCZ has been studied by Guo et al [ 101 ]. The authors have demonstrated that inulin alleviated the damage of brain neurons after 6 weeks of treatment of SCZ mice with inulin.…”

Section: Gut Microbial Diversity Management Strategies To Treat Schiz...mentioning

confidence: 99%

Modulation of Gut Microbial Diversity through Non-Pharmaceutical Approaches to Treat Schizophrenia

Munawar

Ahmad

Anwar

et al. 2022

IJMS

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Schizophrenia (SCZ) is a psychotic syndrome with well-defined signs and symptoms but indecisive causes and effective treatment. Unknown underpinning reasons and no cure of the disease profoundly elevate the risk of illness. Gut microbial dysbiosis related metabolic dysfunction is providing a new angle to look at the potential causes and treatment options for schizophrenia. Because of the number of side effects, including gut dysbiosis, of traditional antipsychotic drugs, new alternative therapeutic options are under consideration. We propose that non-pharmacotherapy using biotherapeutic products could be a potent treatment to improve cognitive impairment and other symptoms of schizophrenia. Use of live microorganisms (probiotics), fibers (prebiotics), and polyphenols alone or in a mixture can maintain gut microbial diversity and improve the two-way relationship of the gut microbiota and the central nervous system. Fiber and polyphenol induced management of gut microbiota may positively influence the gut–brain axis by increasing the level of brain-derived neurotrophic factors involved in schizophrenia. Furthermore, we endorse the need for comprehensive clinical assessment and follow-up of psychobiotic (pro and prebiotics) treatment in mental illness to estimate the level of target recovery and disability reduction in schizophrenia.

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Inulin ameliorates schizophrenia via modulation of the gut microbiota and anti-inflammation in mice

Abstract: The microbiome–gut–brain (MGB) axis, which regulates neurological and cognitive functions, plays an essential role in schizophrenia (SCZ) progression.

Cited by 46 publications

References 79 publications

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

The Microbiota/Microbiome and the Gut–Brain Axis: How Much Do They Matter in Psychiatry?

Changes in the Profile of Fecal Microbiota and Metabolites as Well as Serum Metabolites and Proteome After Dietary Inulin Supplementation in Dairy Cows With Subclinical Mastitis

Modulation of Gut Microbial Diversity through Non-Pharmaceutical Approaches to Treat Schizophrenia

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