Inulin-based hydrogel

Kirtania, Moumita Das; Kahali, Nancy; Maity, Arindam

doi:10.1016/b978-0-12-821649-1.00005-2

Cited by 4 publications

(3 citation statements)

References 80 publications

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“…It contributes to pH-sensitive lysosome-triggered drug delivery systems, improves drug efficacy, and can enhance drug solubility in solid dispersion. 61…”

Section: Inulin Based Hydrogelmentioning

confidence: 99%

Green Fabrication Approach to Hydrogel Synthesis by Using Natural Polymers, their Characterization, and Applications

Mustafa,

Rasheed,

Ansar

et al. 2024

J. Young Pharm.

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Background: Cross-linked networks of polymers are referred to as hydrogels because they possess the ability to retain water within the interstitial spaces of the polymer chains. The fundamental building block of life is a polymer. Researchers' interest in polymers has expanded due to the widespread availability of polymers exhibiting desirable characteristics, a key factor in the development of contemporary healthcare products. The synthesis of hydrogels involves the integration of various natural polymers. In the realm of biomedical applications, hydrogels can be employed to deliver drugs or cells, regenerate both hard and soft tissues, adhere to moist tissues, halt bleeding, provide contrast during imaging, shield tissues or organs from radiation, and enhance the biological adaptability of therapeutic implants. These attributes render hydrogels advantageous for a diverse array of distinct and critical diseases and medical scenarios, as well as in less conventional fields such as environmental engineering. Objectives: The primary objective of this review is to explore the literature related to hydrogels. This includes the classification of hydrogels, examination of natural polymers such as collagen, inulin, pectin, alginate, tragacanth, lignin, and chitosan, which are employed in hydrogel synthesis. The review also covers the general preparation of hydrogels, the methodologies involved in their preparation, common techniques used in characterization, release kinetics, and the diverse applications of hydrogels. Conclusion:This research covers the study of natural polymers such as inulin, alginate, lignin, pectin, collagen, chitosan, and tragacanth, employed in the synthesis of hydrogels. The key areas of focus encompass the classification of hydrogels, procedures for hydrogel preparation, various methods for hydrogel characterization, in vitro and in vivo release kinetics of hydrogels, and the application of hydrogels prepared from specific natural polymers across diverse fields.

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“…It contributes to pH-sensitive lysosome-triggered drug delivery systems, improves drug efficacy, and can enhance drug solubility in solid dispersion. 61…”

Section: Inulin Based Hydrogelmentioning

confidence: 99%

Green Fabrication Approach to Hydrogel Synthesis by Using Natural Polymers, their Characterization, and Applications

Mustafa,

Rasheed,

Ansar

et al. 2024

J. Young Pharm.

View full text Add to dashboard Cite

show abstract

“…The mechanism is mainly utilized to synthesize polymers from monomers containing carbon double bonds. The method consists of three main steps; (1) initiation, (2) propagation, and (3) termination to end the polymer chain propagation [ 180 ]. Click reactions are a class of chemical reactions that are fast, versatile, regiospecific, and highly efficient [ 87 , 181 ].…”

Section: Mechanisms Of Gelationmentioning

confidence: 99%

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Mashabela

Maboa

Miya

et al. 2022

Gels

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Gels are attractive candidates for drug delivery because they are easily producible while offering sustained and/or controlled drug release through various mechanisms by releasing the therapeutic agent at the site of action or absorption. Gels can be classified based on various characteristics including the nature of solvents used during preparation and the method of cross-linking. The development of novel gel systems for local or systemic drug delivery in a sustained, controlled, and targetable manner has been at the epitome of recent advances in drug delivery systems. Cross-linked gels can be modified by altering their polymer composition and content for pharmaceutical and biomedical applications. These modifications have resulted in the development of stimuli-responsive and functionalized dosage forms that offer many advantages for effective dosing of drugs for Central Nervous System (CNS) conditions. In this review, the literature concerning recent advances in cross-linked gels for drug delivery to the CNS are explored. Injectable and non-injectable formulations intended for the treatment of diseases of the CNS together with the impact of recent advances in cross-linked gels on studies involving CNS drug delivery are discussed.

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“…Among the various sources for hydrogel fabrication, polysaccharides have gained significant attention due to their natural abundance, biocompatibility, and structural diversity [ 4 , 14 , 15 , 16 , 17 , 18 ]. Inulin (its structure is shown in Figure 1 ), a naturally occurring polysaccharide composed of linear fructose chains with a glucose unit at the reducing end, has garnered considerable interest as a promising hydrogel precursor [ 19 , 20 ]. Classified as a generally recognized as safe (GRAS) reagent and a versatile dietary fiber, inulin offers several advantages, including its prebiotic properties, low caloric content, and ability to enhance food texture and mouthfeel [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in the Preparation and Application of Inulin-Based Hydrogels

Liang,

Lin,

Zhang

et al. 2024

Polymers

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Inulin, a natural polysaccharide, has emerged as a promising precursor for the preparation of hydrogels due to its biocompatibility, biodegradability, and structural versatility. This review provides a comprehensive overview of the recent progress in the preparation, characterization, and diverse applications of inulin-based hydrogels. Different synthesis strategies, including physical methods (thermal induction and non-thermal induction), chemical methods (free-radical polymerization and chemical crosslinking), and enzymatic approaches, are discussed in detail. The unique properties of inulin-based hydrogels, such as stimuli-responsiveness, antibacterial activity, and their potential as fat replacers, are highlighted. Special emphasis is given to their promising applications in drug delivery systems, especially for colon-targeted delivery, due to the selective degradation of inulin via colonic microflora. The ability to incorporate both hydrophilic and hydrophobic drugs further expands their therapeutic potential. In addition, the applications of inulin-based hydrogels in responsive materials, the food industry, wound dressings, and tissue engineering are discussed. While significant progress has been achieved, challenges and prospects in optimizing synthesis, improving mechanical properties, and exploring new functionalities are discussed. Overall, this review highlights the remarkable properties of inulin-based hydrogels as a promising class of biomaterials with immense potential in the biomedical, pharmaceutical, and materials science fields.

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Inulin-based hydrogel

Cited by 4 publications

References 80 publications

Green Fabrication Approach to Hydrogel Synthesis by Using Natural Polymers, their Characterization, and Applications

Green Fabrication Approach to Hydrogel Synthesis by Using Natural Polymers, their Characterization, and Applications

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Progress in the Preparation and Application of Inulin-Based Hydrogels

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