Invasive Community-Acquired Methicillin-ResistantStaphylococcus aureusin a Japanese Girl with Disseminating Multiple Organ Infection: A Case Report and Review of Japanese Pediatric Cases

Yonezawa, Ryuta; Kuwana, Tsukasa; Kawamura, Kazuro; Inamo, Yasuji

doi:10.1155/2015/291025

Cited by 12 publications

(12 citation statements)

References 20 publications

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“…Panton–Valentine leukocidin (PVL), for instance, is a key virulence factor. Previous studies have shown the association between PVL and severe invasive infections 9,10. Thus, it is important to characterize the virulence factors of CA- S. aureus for improving therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

Community-associated Staphylococcus aureus PVL+ ST22 predominates in skin and soft tissue infections in Beijing, China

Xiao

Yang

Duan

et al. 2019

IDR

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Purpose Community-associated Staphylococcus aureus (CA S. aureus ) is the most common causative pathogen of the skin and soft tissue infections (SSTIs). This study aims to determine clonal distribution, virulence factors of CA S. aureus clinical isolates from purulent SSTIs in Beijing, China. Materials and methods CA- S. aureus isolates were collected from 115 outpatients with purulent SSTIs from the department of dermatology from April 2015 to April 2017. Multilocus sequence typing and Staphylococcus cassette chromosome mec typing were performed to explore molecular characteristics. Phylogenetic analysis of 16S rRNA of dominant S. aureus isolates was performed using MEGA-X software. Virulence genes were detected by PCR, while biofilm formation was evaluated by a microtiter plate method. The antimicrobial susceptibility was tested by an automatic VITEK system. Results Forty-four CA- S. aureus isolates identified from SSTIs contain 9 methicillin-resistant S. aureus (MRSA) isolates (20.4%) and 35 methicillin-susceptible S. aureus isolates (MSSA) (79.6%). The dominant sequence types (STs) were ST22 (40.9%) and clonal complex 59 (CC59; 77.8%) in Community-associated methicillin resistant methicillin-resistant S. aureus . 27.8% of ST22 isolates were homologous to the epidemic ST22 EMRSA-15 in Europe. The prevalence of virulence genes lukS/lukF, tst-1, etA, edinA, icaA , and icaD was 50%, 93.2%, 4.5%, 4.5%, 100%, and 100%, respectively. All CC59 isolates exhibited stronger biofilm-forming capability than ST22 clones. Among the MSSA subgroup, the poor biofilm producers had significantly higher sensitivity to sulfamethoxazole/Trimethoprim. Conclusion The dominant epidemic clone PVL + ST22 MSSA containing tst-1 occurs in Beijing, indicating that a PVL + ST398 clone which was previously predominant in this district had been replaced by a new clone.

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Section: Introductionmentioning

confidence: 99%

Community-associated Staphylococcus aureus PVL+ ST22 predominates in skin and soft tissue infections in Beijing, China

Xiao

Yang

Duan

et al. 2019

IDR

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“…7 MRSA is generally considered to be a typical nosocomial pathogen. 1 However, community-acquired MRSA (CA-MRSA) strains have been reported from patients in different areas beginning in the 1990s. 3 In the past, CA-MRSA infections often occurred in patients who frequently contacted health-care facilities or in specific groups of patients, such as intravenous drug users.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical and bacteriological properties of community-acquired methicillin-resistant S. aureus (CA-MRSA) are different from those of hospital-acquired MRSA. 1 Despite its rarity, meningitis due to CA-MRSA has been associated with serious and occasionally fatal outcomes. Overall, our knowledge of the epidemiological and molecular characteristics of CA-MRSA lineages is limited.…”

Section: Introductionmentioning

confidence: 99%

Community-Acquired Methicillin-Resistant Staphylococcus aureus ST59 in a Chinese Adult with Meningitis: A Case Report from China

Chen¹,

Chen²,

Zhao³

et al. 2020

IDR

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are reported worldwide and are associated with serious outcomes. The majority of CA-MRSA infections are soft tissue and skin infections, and cases with meningitis caused by CA-MRSA are rare. Here, we reported a 53-year-old male patient with meningitis due to CA-MRSA infection, as confirmed by cerebrospinal fluid examination. Whole-genome sequencing data revealed an ST59 CA-MRSA strain encoding PVL and SCCmec IV. Linezolid was administered in this case, and the patient recovered, with no signs of relapse during the one-year follow-up. We present the first case of PVL-positive ST59 CA-MRSA meningitis, with severe manifestations in China.

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“…The first methicillin-resistant staph aureus (MRSA) was discovered by Jevons in the United Kingdom and it is now seen worldwide. The clinical and bacteriological properties of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) are different from those of hospital-acquired MRSA [1]. Despite its increasing distribution, meningitis continues to be associated with serious and occasionally fatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis

Mehmood¹,

Patel²,

Sanekommu³

2020

Cureus

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Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is mostly implicated in soft tissue and skin infections. Cases with meningitis caused by CA-MRSA are rare. High index of suspicion should be kept for physicians as bacterial meningitis is a medical emergency and if untreated, has a high mortality rate. Urgent steps need to be taken to determine the cause and implement therapy. Here, we reported a case of a 58-year-old female with MRSA bacteremia and meningitis as confirmed by positive blood cultures and cerebrospinal fluid analysis; successfully managed with vancomycin and rifampin.

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Invasive Community-Acquired Methicillin-ResistantStaphylococcus aureusin a Japanese Girl with Disseminating Multiple Organ Infection: A Case Report and Review of Japanese Pediatric Cases

Cited by 12 publications

References 20 publications

<p>Community-associated <em>Staphylococcus aureus</em> PVL<sup>+</sup> ST22 predominates in skin and soft tissue infections in Beijing, China</p>

<p>Community-associated <em>Staphylococcus aureus</em> PVL<sup>+</sup> ST22 predominates in skin and soft tissue infections in Beijing, China</p>

<p>Community-Acquired Methicillin-Resistant <em>Staphylococcus aureus</em> ST59 in a Chinese Adult with Meningitis: A Case Report from China</p>

Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis

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