Invasive cutaneous squamous cell carcinoma incidence in US health care workers

Nguyen, Khang; Han, Jiali; Li, Tricia; Qureshi, Abrar A.

doi:10.1007/s00403-014-1469-3

Cited by 16 publications

(16 citation statements)

References 12 publications

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“…Other studies detailing cutaneous SCC incidence in high‐risk populations report much higher incidence rates than those reported in this study . They also report positive APCs or increasing incidence rates .…”

Section: Discussioncontrasting

confidence: 49%

Cutaneous squamous cell carcinoma of the lip: A population‐based analysis

Unsal

Henn

et al. 2017

The Laryngoscope

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Objectives/Hypothesis: The role of cumulative ultraviolet (UV) radiation in cutaneous squamous cell carcinoma of the lip (CSCCL) is well understood. This study seeks to evaluate overall survival as well as incidence and demographics across geographic regions, given differences in UV exposure across the United States.Study Design: Retrospective population-based analysis.Methods: A total of 14,901 CSCCL cases were identified as being from the West, Midwest, South, or Northeast, utilizing the Surveillance, Epidemiology, and End Results registry from 1973 to 2013. Demographics, stage of disease, and treatment modalities were compared among regions.Results: Of the CSCCL cases reported, 58.3%, 24.5%, 10.8%, and 6.4% originated from the West, Midwest, South, and Northeast, respectively. Patients most commonly presented with T1 tumors (81.3%), and nodal and distant metastasis was rare for patients from all regions (3.1% and 0.3%, respectively). Patients with American Joint Committee on Cancer stage II and higher were most likely from the Northeast or South. Overall, most patients were treated with surgery monotherapy (89.5%); however, surgical monotherapy was least commonly utilized in patients in the Northeast and South. Overall 5-year disease specific survival was measured at 94.7%.Conclusion: Although areas of high UV index are implicated in increased morbidity and mortality due to CSCCL, this study indicates that a variety of factors play a role in CSCCL incidence and outcomes in the United States. The elderly and non-white populations were identified as poor prognostic demographic factors. Investigation detailing differences in CSCCL detection and treatment may aid in the identification of higher-risk populations.Key Words: Cutaneous squamous cell carcinoma of the lip, head and neck cancer, lip cancer, SEER, surveillance epidemiology and end results, population-based, survival, cutaneous head and neck cancer.

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Section: Discussioncontrasting

confidence: 49%

Cutaneous squamous cell carcinoma of the lip: A population‐based analysis

Unsal

Henn

et al. 2017

The Laryngoscope

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“…In MM, there was a high male to female ratio (2.6) for tumors of the trunk and low male to female ratio (0.5) for tumors of the leg. In SCC, the head and neck accounted for a larger proportion of lesions for men than women, and the lower limbs were affected more commonly (in our series exclusively) in women, justifying literature data [3,9,15,16,27]. In BCC, the trunk, especially the back, was more frequently involved in men than women, and in comparison, the head and neck region and lower limbs were more frequently affected in women, also corroborating the results from another author [10,11,15,16].…”

Section: Discussionsupporting

confidence: 83%

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

Barto¹,

Kullová²

2017

J Environ Occup Sci

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INTRODUCTIONHuman skin cancers encompass a wide spectrum of malignant conditions with different epidemiologic and clinical characteristics. The three most common malignancies include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), also referred to, collectively, as nonmelanoma skin cancer (NMSC), and malignant melanoma (MM). Although their etiopatogenesis is complex, there is persuasive evidence that an ultraviolet radiation (UVR) has a vital role in the development of each of these main tumor types [1]. However, the relative relationship between the sunlight exposure and the genesis of BCC, SCC, and MM seems to be tumor-specific [1]. These UVR-related differences result in distinct anatomic distribution of the skin cancer types. In general, while MMs arise most commonly on the trunk and limbs [2][3][4][5][6][7], the vast majority of research papers have clearly demonstrated [3,[7][8][9][10][11][12][13] that NMSC occurs predominantly on the head and neck region. In spite of that, however, some studies [4,5,[14][15][16] have found discrepant percentages of BCCs and SCCs at individual body parts compared with the above-mentioned papers and as a consequence, the relative tumor density (RTD) has showed wide variations. The RTD measure was first introduced by Pearl and Scott [17] in 1986, to create a standard way of comparing skin cancers distribution by anatomical sites. It considers the ratio between the proportion of tumor in a certain location and the proportion of the surface area on the same location. This index highlights the differences between the expected and observed occurrence of tumors by site. In this study, we have evaluated the topographic distribution and RTD of three types of cutaneous neoplasms mentioned above and confronted our results with eligible literature data. Results: MMs occurred most commonly on the trunk (46.8%) and the upper limbs (25.3%). While the back and the trunk in particular was sites with the most frequent MM development in males (64.3% and 45.9%), the upper limbs were the most common location in females (34.1%). BCCs and SCCs occurred predominantly on the head and neck, comprising a total of 69.0% and 81.5% of the cases. The face was a region with by far the highest RTDs in BCC and SCC patients. Men had more frequently affected extrafacial sites of the head and neck compared to women in both BCC (46% vs. 31.9%) and SCC (62.5% vs. 48.3%) cases. In BCC, the second most frequent anatomic site included the back in both genders (25.1% in males, 18.2% in females), but in SCC, it represented the trunk as a whole in males (13.6%), and the lower limbs in females (14.3%). The greatest differences in RTDs between BCC and SCC were on the back (BCC: SCC ratio, 7.5:1), especially in men (BCC: SCC ratio, 9:1). Conclusion: We have confirmed striking heterogeneity for skin cancer risk by anatomic site. While MMs arise predominantly on the body parts intermittently exposed to the sunlight, BCCs and especially SCCs develop most frequently on the sites that are habitually exposed to ...

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“…9 According to a study of US health care workers that analyzed prospective questionnaires obtained from more than 250,000 participants enrolled in 3 large cohort studies from 1976 to 2008, the incidence of invasive cSCC increased over 18 years of follow-up. 10…”

Section: Introductionmentioning

confidence: 99%

Guidelines of care for the management of cutaneous squamous cell carcinoma

Alam

Armstrong

Baum

et al. 2018

Journal of the American Academy of Dermatology

368

258

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Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human cancer and has an increasing annual incidence. Although most cSCC is cured with office-based therapy, advanced cSCC poses a significant risk for morbidity, impact on quality of life, and death. This document provides evidence-based recommendations for the management of patients with cSCC. Topics addressed include biopsy techniques and histopathologic assessment, tumor staging, surgical and nonsurgical management, follow-up and prevention of recurrence, and management of advanced disease. The primary focus of these recommendations is on evaluation and management of primary cSCC and localized disease, but where relevant, applicability to recurrent cSCC is noted, as is general information on the management of patients with metastatic disease.

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Invasive cutaneous squamous cell carcinoma incidence in US health care workers

Cited by 16 publications

References 12 publications

Cutaneous squamous cell carcinoma of the lip: A population‐based analysis

Cutaneous squamous cell carcinoma of the lip: A population‐based analysis

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

Guidelines of care for the management of cutaneous squamous cell carcinoma

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