Invasive micropapillary carcinoma of the breast: A prognostic study*1

Paterakos, Michael; Watkin, William; Edgerton, Susan M.; Moore, Dan H.; Thor, Ann D.

doi:10.1016/s0046-8177(99)90168-5

Cited by 169 publications

(143 citation statements)

References 7 publications

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“…Involvement of multiple LNs is also typical. In our series, an average of 6 nodes were involved with axillary metastases compared to 9.5 in the study of Luna-More (14) and 8.5 in Paterakos series (13). It is possible that tumor foci with IMPCa growth pattern are a source of LN metastases, since examination of axillary contents revealed IMPCa differentiation in most cases.…”

Section: Discussionmentioning

confidence: 40%

“…The patients who died from their breast cancers had larger tumor size, higher histological grade, and a higher number of metastatic lymph nodes (11,15). Paterakos et al, in their multivariate analysis of 21 cases of IMPCa, failed to confirm that IMPCa phenotype predicted more aggressive clinical behavior and a shortened disease free or overall survival (13). In our study we showed the survival of IMPCa cases was similar to that of infiltrating ductal carcinoma when matched for node status.…”

Section: Discussionmentioning

confidence: 51%

“…Luna-More et al, and Paterakos et al reported 91% and 95% incidences of axillary node metastases respectively (11,13). Involvement of multiple LNs is also typical.…”

Section: Discussionmentioning

confidence: 97%

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Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast Carcinoma

et al. 2001

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Invasive micropapillary carcinoma (IMPCa) of breast is histologically characterized by growth of cohesive tumor cell clusters within prominent clear spaces resembling dilated angiolymphatic vessels. In this study, eighty three breast carcinomas with IMPCa differentiation were identified by review of the invasive carcinoma cases in our institution and correlated retrospectively with standard clinicopathologic parameters and survival status relative to a control series of cases (mean follow up 7 years). IMPCa growth pattern was present in 6% of all breast carcinomas; it was generally a focal component in otherwise typical invasive ductal carcinoma. It comprised more than 80% of the total neoplasm in only 10 cases (12%), 50 -80% of the neoplasm in 7 cases (8%), 20 -50% of the neoplasm in 22 cases (26%) and less than 20% in 44 cases (53%). The mean tumor size was 4 cm, 22% invaded skin, and 58% were poorly differentiated, but 71% were ER positive. Axillary node metastases were present in 77% of cases, were typically multiple (51% had three or more positive), and usually contained an IMPCa component (81% of the cases). There was no significant difference in node status, ER status, size, tumor grade, or peritumoral angiolymphatic invasion between tumors with predominant (more than 50%) v/s focal IMPCa components. In both groups 46% of the patients died from their disease (mean interval to death ‫؍‬ 36m). Skin involvement and nodal status were the only parameters which predicted poor survival (P ‫؍‬ .01). The outcome of patients with IMPCa did not differ significantly from infiltrating ductal carcinomas of similar node status. In conclusion, our results suggest that IMPCa growth pattern may be a manifestation of aggressive behavior, as shown by frequent skin invasion and extensive nodal involvement. However, clinicopathologic features and outcome of IMPCa are not strongly dependent on the relative amount of micropapillary component.

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 51%

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Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast Carcinoma

et al. 2001

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“…Except for the ovary, micropapillary carcinoma arising in many organs seems to pursue an aggressive clinical course because of frequent invasion into lymphatic spaces, metastasis into lymph nodes, or systemic metastasis (Verdú et al;Amin et al, 2002;Amin et al, 1994;Nassar;Nassar et al;Paterakos et al;Siriaunkgul & Tavassoli;Zekioglu et al;Haupt et al;Kim et al;Kuroda et al;Sakamoto et al;Wen et al;Xu et al). Micropapillary carcinoma of the colon macroscopically seems to be indistinguishable from conventional adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…The micropapillary carcinoma is regarded as an aggressive variant of adenocarcinoma in any location described, namely bladder, lung, pancreas, salivary glands and recently colon, rectum and stomach (Verdú et al, 2011;Amin et al, 2002;Amin et al, 1994;Nassar, 2004;Nassar et al, 2001;Paterakos et al, 1999;Siriaunkgul & Tavassoli, 1993;Zekioglu et al, 2004). Histologically is characterized by papillary cell clusters surrounded by clear spaces.…”

Section: Introductionmentioning

confidence: 99%

Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity

Lino-Silva

2012

Int. J. Morphol.

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LINO-SILVA, L. S. Pure micropapillary rectal carcinoma with CK7 and CK20 coexpression and loss of CDX2 reactivity. Int. J. Morphol., 30(1):25-29, 2012. SUMMARY:The micropapillary carcinoma is regarded as an aggressive variant of adenocarcinoma in any location. Histologically is characterized by papillary cell clusters surrounded by clear spaces. The reported proportion of micropapillary carcinoma component to the entire tumor ranged from 5 to 80% and no pure cases has been reported. There are near of 130 cases reported to date in colorectum. We experienced a patient with a pure micropapillary carcinoma showing coexpression of CK7, CK20, and absence of CDX2, which had an aggressive neoplasm with extense perineural, vascular and lymphatic invasion also extensive nodal metastasis. The presence of a micropapillary carcinoma in the colorectum seemed to be closely related with nodal metastasis, similar to the case for micropapillary carcinomas in other organs. Therefore, if a micropapillary component is identified in a tumor, particularly in a biopsy specimen, even if the pre-operative diagnosis is a pedunculated early colorectal cancer, should be carefully consider the extent of surgical resection due to the high potential for nodal metastasis.

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Fine-needle aspiration cytology findings of an uncommon micropapillary variant of pure mucinous carcinoma of the breast

2002

Cancer

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BACKGROUND Previous attempts at subclassifying pure mucinous carcinomas of the breast based on architectural patterns and other associated features are on record. A distinctive micropapillary variant with most tumor cells arranged in micropapillae/pseudoacini has not been described previously. METHODS The author reviewed the histologic slides from all 556 patients who underwent wide excision/mastectomy for mammary ductal carcinoma, either in situ or invasive, at Pamela Youde Nethersole Eastern Hospital, Hong Kong, during an 8‐year period from early 1994 to the end of 2001. Five patients with pure mucinous carcinoma with diffuse micropapillary architecture were noted. The cytologic features (if available) were correlated with clinical, radiologic, and pathologic findings. RESULTS Among the five patients with pure mammary mucinous carcinoma (micropapillary variant), three patients underwent preoperative fine‐needle aspiration biopsies and had specimens available for review. The direct smears and cytospin preparations were of moderate cellularity and showed cohesive clusters and micropapillae of mildly pleomorphic tumor cells among a mucoid background. True tumor papillae with fibrovascular cores were not present. Nuclear hobnailing was observed commonly, and occasional psammoma bodies were found. There were also scanty isolated tumor cells scattered around. The pseudoacinar pattern was appreciated more readily in the cell block sections. Histologic examination of the surgical specimens showed features of pure mucinous carcinoma with diffuse micropapillary architecture. The micropapillary arrangement was confirmed further by the demonstration of a reverse polarity immunostaining pattern for epithelial membrane antigen and the identification of microvilli rimming the periphery of tumor cell clusters under the electron microscope. Peritumoral lymphovascular permeation and ipsilateral axillary lymph node metastasis was found in one of the patients. CONCLUSIONS The micropapillary variant of mammary mucinous carcinoma demonstrates characteristic cytologic and histologic features that warrant special attention. It may represent the mucinous counterpart of invasive micropapillary carcinoma. Further analysis of a larger series of patients, however, will be required to delineate its prognostic significance, especially its propensity for lymph node metastasis. Cancer (Cancer Cytopathol) 2002;96:280–8. © 2002 American Cancer Society.

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Invasive micropapillary carcinoma of the breast: A prognostic study*1

Cited by 169 publications

References 7 publications

Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast Carcinoma

Clinicopathologic Analysis of Invasive Micropapillary Differentiation in Breast Carcinoma

Pure Micropapillary Rectal Carcinoma with CK7 and CK20 Coexpression and Loss of CDX2 Reactivity

Fine-needle aspiration cytology findings of an uncommon micropapillary variant of pure mucinous carcinoma of the breast

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