Invasive Squamous Cell Carcinoma of the Conjunctiva First Misdiagnosed as a Pterygium: A Clinicopathologic Case Report

Mirza, Ertugrul; Gümüş, Koray; Evereklioğlu, Cem; Arda, Hatice; Öner, Ayşe; Canöz, Özlem; Karaküçük, Sarper

doi:10.1097/icl.0b013e31815700af

Cited by 17 publications

(16 citation statements)

References 10 publications

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“…This finding must be placed in the context of the potential catastrophic repercussions of undiagnosed OSSN. [24][25][26] The rate of concomitant OSSN in pterygia specimens varies worldwide from 0% to 9.8% as summarized in Table 1. In a retrospective analysis of 2005 pterygia pathology records in Miami, FL, 1.7% were found to have OSSN of which 41% were clinically ''suspected'' preoperatively and 59% were unexpectedly found on histopathology.…”

Section: Discussionmentioning

confidence: 99%

A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

Segev

Tessler

Hilely

et al. 2014

Current Eye Research

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Section: Discussionmentioning

confidence: 99%

A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

Segev

Tessler

Hilely

et al. 2014

Current Eye Research

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“…OSSN can occur with corneal ulcer [16], chronic blepharoconjuctivitis [17], pterygium [6,19,20], necrotizing scleritis [21,22], sclerokeratitis[18,29], orbital cellulitis [23], superior limbic keratoconjuctivitis [24], ocular prosthesis [25,26], fibroxanthoma[27], and MMP [28]. In the published literature, several cases of the OSSN were not recognized clinically, but were found when biopsies were done for other presumed diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

et al. 2017

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Purpose Coexistence of an ocular surface disease can mask the typical features of ocular surface squamous neoplasia (OSSN). The purpose of this study was to evaluate high resolution optical coherence tomography (HR-OCT) as an adjunct in the detection and differentiation of OSSN within coexisting ocular surface pathologies. Methods Retrospective study of 16 patients with ocular surface disease and lesions suspicious for OSSN that were evaluated with HR-OCT. HR-OCT images of the lesions were taken to look for evidence of OSSN. Biopsies were performed in all cases, and the HR-OCT findings were compared to the histological results. Results Of the 16 patients with OSSN and a coexisting ocular surface disease, 12 were found to have OSSN by HR-OCT and all were subsequently confirmed by biopsy. Two patients had OSSN with rosacea, one with pingueculum, two within pterygia, one with Salzmann’ nodular degeneration, six with limbal stem cell deficiency (LSCD)/scarring. In all 12 cases HR-OCT images revealed classical findings of hyper-reflective, thickened epithelium and an abrupt transition from normal to abnormal epithelium. OSSN was ruled out by HR-OCT in four cases (2 Salzmann’s, 1 mucous membrane pemphigoid, and 1 LSCD). Negative findings were confirmed by biopsy. HR-OCT was used to follow resolution of the OSSN in positive cases, and it detected recurrence in 1 case. Conclusions While histopathology is the gold standard in the diagnosis of OSSN, HR-OCT can be used to noninvasively detect the presence of OSSN in patients with coexisting ocular conditions.

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“…Skvamocelularni karcinom može dati kliničku sliku pterigijuma i skoriji radovi su pokazali u pterigijumu prisustvo neočekivanih sekundarnih potencijalno malignih oboljenja epitela pterigijuma -konjunktivalnih intraepitelnih neoplazija ("conjunctival intraepithelial neoplasia-CIN") [4][5][6][7][8]. Ramasamy i saradnici [5] su prikazali pterigijum koji je zbog temporalne interpalpebralne lokacije i zapaljenja nakon ekscizije histološki analiziran.…”

Section: Diskusijaunclassified

“…[7] i Rootman i sar. [6] su opisali skvamocelularne karcinome konjunktive koji su prethodno pogrešno dijagnostikovani kao pterigijumi.…”

Section: Diskusijaunclassified

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Conjunctival dysplasia in pterygium – case report

Ljubojević

Gajanin²,

Mavija³

et al. 2013

Biomedicinska istraž.

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The study concerns a 65-year-old female patient with pterygium of right eye and histologically verified conjunctival intraepithelial neoplasia. The lesion was diagnosed as pterygium and treated surgically. Histological examination of the excised material found the presence of conjunctival intraepithelial neoplasia. The significance of this case report is in pointing out the presence of morphological changes in pterygium that may precede the development of squamocellular carcinoma of the conjunctiva and the necessity of histological examination of all excised pterygia.

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Invasive Squamous Cell Carcinoma of the Conjunctiva First Misdiagnosed as a Pterygium: A Clinicopathologic Case Report

Abstract: All pterygia should be evaluated meticulously with regard to possible underlying causes, such as carcinoma in situ or squamous cell carcinoma, and all excised lesions should also be evaluated pathologically to prevent such serious adverse outcomes that are mentioned in this case report.

Cited by 17 publications

References 10 publications

A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

A 10-Year Survey: Prevalence of Ocular Surface Squamous Neoplasia in Clinically Benign Pterygium Specimens

Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases

Conjunctival dysplasia in pterygium – case report

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