Vaccines are biological products that have an important role in human immunity. In Indonesia, some vaccines are categorized as compulsory vaccines and additional vaccines. The demand for additional vaccines is less predictable because they are not mandatory for use. This of course makes the amount of demand for vaccines less predictable. Also, the price of additional vaccines is not cheap when compared to the price of mandatory vaccines. So that the management of vaccines in the pharmacy warehouse is needed so that the amount of supply and demand is balanced so that the costs incurred will be more optimal. The information system regarding vaccine reordering is carried out using a reorder point so that the pharmacy warehouse can order according to the right need and at the right time. The data used are demand data, prices, storage costs, and message costs. The results of calculations using reorder points within four months with a total purchase for the Rotavirus vaccine was 62 for IDR 28,274,948 and 70 for the hospital of IDR 31,801,500 with a difference of IDR 3,528,552. The calculation result using the reorder point for the Hexaxim vaccine with a total purchase for 4 months was 61 with a nominal value of IDR 58,380,060 while the calculation in the hospital was 67 with a nominal value of IDR 63,971,000 so that a nominal difference of IDR 5,590,940 was obtained. Use of the return point can be used to alarm when and how many vaccines to order. This can be seen from the cost difference between the pharmacy warehouse and the calculation using the reorder point for the Hexaxim vaccine and the Rotavirus vaccine.