Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study

Tresserra‐Rimbau, Anna; Rimm, Eric B.; Medina‐Remón, Alexander; Martínez-González, M Á; Torre, Rafael de la; Corella, Dolores; Salas‐Salvadó, Jordi; Gómez‐Gracia, Enrique; Lapetra, José; Arós, Fernando; Fiol, Miquel; Ros, Emili; Serra-Majem, Lluís; Pintó, Xavier; Sáez, Guillermo; Basora, Josep; Sorlí, José V.; Martínéz, J. Alfredo; Vinyoles, Ernest; Ruı́z-Gutı́errez, Valentina; Estruch, Ramón; Lamuela‐Raventós, Rosa María

doi:10.1016/j.numecd.2013.12.014

Cited by 288 publications

(247 citation statements)

References 29 publications

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“…Recovery of urinary metabolites and plasma pharmacokinetics of flavan-3-ol, flavanone and dihydrochalcone phase II metabolites absorbed in the proximal and distal gastrointestinal tract were broadly comparable to other feeding studies with green tea, coffee, apple cider, orange juice and green tea (11). The active beverage delivered a daily polyphenol dose of 722mg; comparable to that reported in observational studies examining the effect of a Mediterranean Diet high in (poly)phenol foods on cardiovascular events (32).…”

Section: Discussionsupporting

confidence: 76%

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

et al. 2016

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Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical comorbidity in a randomized placebo controlled pilot study. Methods: Randomly assigned active 250ml beverages containing 361mg of (poly)phenols and 120mg of vitamin C or placebo (no polyphenol / vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. Results:Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (log∆ area under perfusion curve) of 0.30 (-0.65, 1.26) and 0.35 (-0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029m/s (-0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C, insulin, adiponectin, CRP, ICAM-1, E-Selectin or t-PA, but IL-6 increased in active versus placebo recipients (0.32 vs -0.18 pg/ml; p=0.010). Conculsion: There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk. PWV pulse wave velocity; SNP sodium nitroprusside; ACh acetyl choline, HPLC-MS 2 high performance liquid chromatography-tandem mass spectrometry

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Section: Discussionsupporting

confidence: 76%

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

et al. 2016

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“…24-h dietary recall (8)(9)(10)(11)16), FFQs (15,(17)(18)(19)(20), and several-day food diaries (13,21), no methodological study has been performed to estimate polyphenol intake. Dietary assess-ment is usually conducted for the purpose of ranking individuals within a group, or assessing an individual's usual intake.…”

mentioning

confidence: 99%

Dietary Polyphenol Intake Estimated by 7-Day Dietary Records among Japanese Male Workers: Evaluation of the Within- and Between-Individual Variation

Taguchi

Kishimoto

Fukushima³

et al. 2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Polyphenol intake has been estimated in some populations; however, information about day-to-day and individual differences in polyphenol intake has not been wellevaluated. In this study, we aimed to examine within-and between-individual variation in polyphenol intake in Japanese male workers. First, 56 male subjects (aged 37.9610.4 y) completed detailed 7-d dietary records (DR). We then calculated their total polyphenol intake using our polyphenol content database and the within-and between-individual variations. We also estimated the minimum number of days of dietary assessment required both to rank individuals within a group and to assess an individual's usual polyphenol intake with acceptable accuracy. The estimated daily total polyphenol intake was 9656471 mg/d, which was largely sourced from beverages. The day-to-day variation (CVw) for polyphenol intake was 43.6%, and the variation between the individuals in the population (CVb) for polyphenol intake was 45.9%. A 4-d DR was required to rank individuals within a group with high correlation coefficients (r50.9), and a 19-d DR was required to assess the individual's usual polyphenol intake with 20% deviation. The CVw for polyphenol intake was intermediate between those of the other nutrients, but the CVb for polyphenol intake was largest among the nutrients. These results suggest that the dietary intake of polyphenols should be carefully estimated considering its within-and between-individual variation.

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“…Data on their dietary habits were collected with a validated food frequency questionnaire, and the polyphenol content in foods was obtained from the Phenol-Explorer database. Results showed a signiicant reduction of cardiovascular events and cardiovascular mortality with a higher intake of total polyphenols, especially lavanols, lignans, and hydroxybenzoic acids [11]. The aim of this study was also to investigate the efect of polyphenol intake on all-cause mortality.…”

Section: Health Beneitsmentioning

confidence: 98%

Polyphenols: Food Sources and Health Benefits

Mrduljaš¹,

Krešić²,

Bilušić³

2017

Functional Food - Improve Health Through Adequate Food

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The current scientiic knowledge on the relationship between diet and human health is greatly focused on the efects of phytochemicals, especially polyphenols, on chronic diseases, due to their preventive efect as shown by many epidemiological studies. Herbs, cocoa products, and darkly colored berries, such as black elderberries, chokeberries, and black currants, are the richest dietary sources that contribute to the average intake of polyphenols of about 1 g/day. Polyphenols that are the most common in the human diet are not necessarily the most active in the body because their beneicial efects depend on the plant matrix in which they are incorporated and on processing methods and endogenous factors such as microbiota and digestive enzymes. Polyphenol-rich foods are considered as being potential functional foods due to antioxidant, anti-inlammatory, antimicrobial, immunomodulatory, anticancer, vasodilating, and prebiotic-like properties. This review will outline indings on the preventive efects of polyphenols on chronic diseases, the factors afecting polyphenol bioavailability and bioaccessibility, and new trends in functional food production.

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Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study

Cited by 288 publications

References 29 publications

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

Dietary Polyphenol Intake Estimated by 7-Day Dietary Records among Japanese Male Workers: Evaluation of the Within- and Between-Individual Variation

Polyphenols: Food Sources and Health Benefits

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