Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

Xiao, Fangjun; Peng, Peng; Gao, Shihua; Lin, Tianye; Fang, Weihua; He, Wei

doi:10.3389/fmed.2022.929709

Cited by 13 publications

(12 citation statements)

References 39 publications

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“…Furthermore, a study demonstrated an inverse correlation between HDL-C levels and BMD [ 32 ]. In the NHANES 2011–2018 data, a study conducted by Xiao et al found a negative relationship between LDL-C levels and lumbar BMD in the young- and middle-aged population [ 5 ]. Additionally, Wang's study, after accounting for all relevant covariates, revealed an interesting inverted U-shaped curve representing the correlation between HDL-C levels and total BMD among adolescents aged 16–19 [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…As life expectancy has increased, there has been a rise in the prevalence of osteoporosis, leading to a decline in quality of life and an increase in medical expenses. Apart from genetic factors, age, and lifestyle choices [ 3 , 4 ], such as lipid or glucose metabolism [ 5 – 7 ], have recently drawn considerable attention due to their influence on bone metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

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Objective Disorders in glucose and lipid metabolism have been shown to exert an influence on bone metabolism. The TyG index, which combines measures of glucose and triglycerides, provides insights into the overall metabolic status. However, the investigation of concurrent disturbances in glucose and lipid metabolism and their specific implications for bone metabolism remains limited in the existing research literature. This study aimed to explore the correlation between the TyG index and bone mineral density (BMD) in US adults. Methods In the National Health and Nutrition Examination Survey (NHANES), subjects were classified based on the TyG index into four groups (< 7.97, 7.97–8.39, 8.39–8.85, > 8.86). Linear regression analysis was conducted to determine the β value and 95% confidence interval (CI). Four multivariable models were constructed. Restricted cubic spline analyses and piecewise linear regression were employed to identify the association between the BMD and TyG index. An analysis of subgroups was also conducted in this study. Results Significant variations in related characteristics were found among the US adult population, who were distributed into four groups based on the quartiles of the TyG index. A negative correlation between the TyG index and lumbar spine BMD was observed. In the multi-adjusted models, compared to Q1 of the TyG index, the β for Q4 of the TyG index for lumbar spine BMD was [β = − 0.008, 95% CI (− 0.017, 0)] in US adults. The association between the TyG index and lumbar spine BMD was found to be nonlinear (all nonlinear p < 0.001), with a threshold value based on restricted cubic spline analyses. Above the threshold point, the β for lumbar spine BMD was − 0.042 (95% CI, − 0.059, − 0.024). Below the threshold points, no significant difference was observed (p > 0.05). No significant interactions were observed among subgroups based on age, gender, presence of diabetes, BMI, and use of antidiabetic and antihyperlipidemic agents. Similar patterns of association were observed in total and subtotal bone density. Conclusions This study identified a nonlinear association between the TyG index and BMD in the US population. Furthermore, an increased level of the TyG index may indicate a higher risk of osteoporosis among US adults. These findings highlight the importance of considering glucose and lipid metabolism disturbances in understanding bone health and the potential for developing preventive strategies for osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Zhan,

Liu,

Piao

et al. 2023

J Orthop Surg Res

View full text Add to dashboard Cite

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“…Further subgroup analyses after stratification by age indicated negative associations in the age group of 30–49 years. In the subgroup analysis stratified for BMI, there was an inverse correlation between BMD and LDL-C in overweight people (25 ≤ BMI < 30) [ 22 ]. A further NHANES study found a negative association between BMD and LDL-C.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 2 Diabetes Mellitus—A Retrospective Study Based on Inpatients in Beijing, China

et al. 2023

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Objective: to analyze the association between blood lipid metabolism and osteoporosis (OP) in older adults with type 2 diabetes mellitus (T2DM). Methods: a total of 1158 older patients with T2DM treated by the Department of Endocrinology, Peking University International Hospital, were retrospectively analyzed, including 541 postmenopausal women and 617 men. Results: (1) Levels of low-density lipoprotein cholesterol (LDL-C) were significantly higher in the OP group, while levels of high-density lipoprotein cholesterol (HDL-C) were higher in the non-osteoporotic group (both p < 0.05). (2) Age, parathyroid hormone (PTH), total cholesterol (TC) and LDL-C were negatively linked to the patients’ bone mineral density (BMD) (all p < 0.05), while the body mass index (BMI), uric acid (UA) level, HDL-C level and glomerular filtration rate (eGFR) were positively related to their BMD (all p < 0.05). (3) In postmenopausal women, after adjustment for other indexes, raised LDL-C is an independent risk factor for OP (OR = 3.38, 95% CI 1.64, 6.98, p < 0.05) while raised HDL-C is protective (OR = 0.49, 95% CI 0.24, 0.96, p < 0.05). However, raised HDL-C was protective against OP (OR = 0.07, 95% CI 0.01, 0.53, p < 0.05). Conclusion: In older T2DM patients, the effect of blood lipid levels is related to sex. Our study conducted a detailed sex stratification. In addition to seeing the traditional risk factors of OP, such as age, sex, and BMI, we comprehensively analyzed the correlation between the blood glucose level, complications, and blood lipids with OP. HDL-C is a protective factor for OP in both men and women, while LDL-C independently predicts OP in postmenopausal women.

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“…In this study, serum LDL-C and TC levels and the LDL-C/TC ratio of middle-aged and older adults with osteopenia in Southwest China increased signi cantly, and changes in LDL-C and TC in this population were consistent with previous articles. 5,[12][13][14][15][16][17][18] Whether LDL-C/TC is related to the change in bone mass has not been reported in previous articles. For example, in a study of patients with gestational diabetes, it was found that patients with gestational diabetes mellitus with high serum levels of TC and LDL-C have low BMD.…”

Section: Discussionmentioning

confidence: 99%

The increase in low-density lipoprotein cholesterol in total cholesterol is correlated with osteopenia in middle-aged and older adults

Zhao,

Pan,

et al. 2023

Preprint

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Objective To study the correlation between the proportion of low-density lipoprotein cholesterol in total cholesterol and osteopenia in middle-aged and older adults. Methods From July 2016 to November 2016, 711 middle-aged and older adults aged 40–90 years in Southwest China were selected by random cluster sampling. The bone mineral density (BMD) of subjects was measured from the calcaneus by using an ultrasound bone densitometer (OSTEOSPACE), and the T value was calculated. According to the diagnostic criteria for osteopenia and the inclusion and exclusion criteria formulated by the WTO, 254 subjects with normal bone mass and 111 subjects with reduced bone mass were obtained. The serum of these subjects was collected, and the levels of LDL-C and TC and the ratio of LDL-C/TC in the serum were determined by the enzymatic method. The values of T, LDL-C, and TC levels and the LDL-C/TC ratio of 16,465 people from 2013 to 2018 were obtained from the NCHS NHANES database (National Center for Health Statistics). The rank sum test was used to analyze the differences in various indexes in different groups of samples, and linear regression and binary logistic regression analysis were used to explore the correlation between osteopenia and LDL-C and TC levels and the LDL-C/TC ratio. Results Compared to the normal group, the levels of LDL-C and TC and the LDL-C/TC ratio in the osteopenia group were higher (P < 0.05). Binary logistic regression analysis showed that after adjusting for age, sex, and BMI as related factors, serum LDL-C (OR = 1.452, P < 0.01), TC (OR = 1.264, P < 0.01) and LDL-C/TC (OR = 21.161, P < 0.05) were risk factors for osteopenia in middle-aged and older adults. LDL-C and TC levels in osteopenia groups of all ages were relatively high (Fig. 2). According to the verification of the database, after adjusting for age, sex, and BMI as related factors, LDL-C (OR = 1.353, P < 0.001), TC (P < 0.001, OR = 1.293), LDL-C/TC (OR = 13.743, P < 0.01). Conclusion The high proportion of low-density lipoprotein cholesterol in total cholesterol is correlated with osteopenia in middle-aged and older adults.

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Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011–2018

Cited by 13 publications

References 39 publications

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study

Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 2 Diabetes Mellitus—A Retrospective Study Based on Inpatients in Beijing, China

The increase in low-density lipoprotein cholesterol in total cholesterol is correlated with osteopenia in middle-aged and older adults

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