Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities

Czeizel, Andr̀ew E.; Puhó, Erzsébet; Ács, Nándor; Bánhidy, Ferenc

doi:10.1002/ajmg.a.31097

Cited by 29 publications

(24 citation statements)

References 38 publications

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“…In addition a lower occurrence of severe nausea and vomiting during the study pregnancy of case mothers and malformed controls was observed compared to the mothers of matched and all controls. Our previous study showed some CA-preventive effect of severe nausea and vomiting in pregnancy [38] and now this finding was confirmed in the origin of VSD as well.…”

Section: Discussionsupporting

confidence: 59%

Ventricular septal defects in function of maternal sociodemographic aspects

Vereczkey¹,

Kósa²,

Csáky-Szunyogh

et al. 2012

Open Medicine

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AbstractThe objective of our project is to reveal the possible etiological factors of different congenital cardiovascular abnormalities. In this study, we evaluated single ventricular septal defect (VSD) after surgical correction or with lethal outcome. The birth outcomes of these cases in the function of maternal socio-demographic features were evaluated. Data are based on 1,659 VSD cases, 2,534 matched controls and 38,151 all controls without any defects, in addition in the mothers of 19,393 malformed controls with other isolated defects in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. VSD had mild female excess with a higher rate of preterm birth and mainly low birth weight indicating intrauterine growth restriction of affected fetuses, particularly in males and full-term or average weighted cases. The mothers of cases with VSD had lower socioeconomic status and higher rate of smoking and particularly drinking habit. The evaluation of medically recorded pregnancy complications showed an association of gestational diabetes with a higher risk of VSD. In conclusion, the association of small localized size of VDS and obvious fetal growth restriction needs further explanation in these cases, while gestational diabetes, lower socioeconomic status and adverse lifestyle of pregnant women may have a role in the origin of VSD.

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Section: Discussionsupporting

confidence: 59%

Ventricular septal defects in function of maternal sociodemographic aspects

Vereczkey¹,

Kósa²,

Csáky-Szunyogh

et al. 2012

Open Medicine

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show abstract

“…Neither did medication commonly prescribed to treat heartburn or other digestive complaints. The known protective effect of nausea and vomiting over the prevalence of malformations was not evident in our analysis [22].…”

Section: Discussionmentioning

confidence: 50%

Impact and risk factors of craniofacial malformations in a Colombian population

Zarante

López

Camilo

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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“…Our previous study showed that severe nausea or vomiting in pregnancy resulted in some protective effect for several CAs. 23 Thus, our hypothesis is that there is some relationship between maternal hypotension and the higher incidence of severe nausea or vomiting in pregnant women. Together, they may be associated with a mild protective effect against some CAs.…”

Section: Discussionmentioning

confidence: 99%

Hypotension in pregnant women: a population-based case–control study of pregnancy complications and birth outcomes

et al. 2010

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Hypotension is frequent in pregnant women; nevertheless, its association with pregnancy complications and birth outcomes has not been investigated. Thus, the aim of this study was to analyze the possible association of hypotension in pregnant women with pregnancy complications and with the risk for preterm birth, low birthweight and different congenital abnormalities (CAs) in the children of these mothers in the population-based data set of the Hungarian Case-Control Surveillance of CAs, 1980CAs, -1996 Prospectively and medically recorded hypotension was evaluated in 537 pregnant women who later had offspring with CAs (case group) and 1268 pregnant women with hypotension who later delivered newborn infants without CAs (control group); controls were matched to sex and birth week of cases (in the year when cases were born), in addition to residence of mothers. Over half of the pregnant women who had chronic hypotension were treated with pholedrine or ephedrine. Maternal hypotension is protective against preeclampsia; however, hypotensive pregnant women were at higher risk for severe nausea or vomiting, threatened abortion (hemorrhage in early pregnancy) and for anemia. There was no clinically important difference in the rate of preterm births and low birthweight newborns in pregnant women with or without hypotension. The comparison of the rate of maternal hypotension in cases with 23 different CAs and their matched controls did not show a higher risk for CAs (adjusted OR with 95% confidence intervals: 0.66, 0.49-0.84). In conclusion, a higher risk for CAs and other adverse birth outcomes was not found in the offspring of pregnant women with hypotension, but maternal hypotension was associated with a higher risk of some pregnancy complications. Keywords: congenital abnormalities; hypotension; hypotension drugs; pregnancy; pregnancy complications INTRODUCTION Hypertension is a common medical condition that has multiple manifestations, including primary and secondary hypertension disease, preeclampsia and gestational hypertension in pregnant women. 1-3 However, the study of the other end of the blood pressure spectrum (that is, hypotension) has been neglected in pregnant women 4 even though hypotension occurs frequently during pregnancy. We were unable to find controlled epidemiological studies regarding the effect of hypotension and related drug treatments for pregnancy complications or adverse birth outcomes in the medical literature. 5 This medical attitude is partially understandable because hypotension is not a disease; rather, it is a symptom of low blood pressure in individuals and is generally not associated with serious complications.Hypotension occurs frequently in Hungarian pregnant women, and obstetricians, in general after consultation with specialists, prefer to treat the more severe and unpleasant symptomatic manifestations of hypotension during pregnancy. However, the potential teratogenic/

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Inverse association between severe nausea and vomiting in pregnancy and some congenital abnormalities

Cited by 29 publications

References 38 publications

Ventricular septal defects in function of maternal sociodemographic aspects

Ventricular septal defects in function of maternal sociodemographic aspects

Impact and risk factors of craniofacial malformations in a Colombian population

Hypotension in pregnant women: a population-based case–control study of pregnancy complications and birth outcomes

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