Inverse association between yerba mate consumption and idiopathic Parkinson's disease. A case–control study

Gatto, Emilia; Melcon, Carlos; Parisi, Virginia; Bartoloni, Leonardo; Gonzalez, Claudio

doi:10.1016/j.jns.2015.06.043

Cited by 19 publications

(19 citation statements)

References 43 publications

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“…A unique tea, yerba mate, which is an infusion made from dried, toasted, and milled leaves and stemlets of the Ilex paraguariensis , which is widely consumed in South American countries, was investigated in a case‐control study in Argentina and was shown to have a similar risk reduction to conventional tea consumption with an OR of 0.64 (95% CI: 0.54–0.76) …”

Section: Analytical Epidemiologymentioning

confidence: 99%

“…78,108 Case-control studies 2 case-control studies performed in China; both studies showed showed a reduced risk for PD (OR 0.20-0.48). 49,82 1 case-control study performed in the USA showed that physical activity was associated with reduced risk for PD: OR 0.50 to 0.64 depending on the age in which the person engaged in physical activity. 109 1 case-control study study performed in the USA showed that certain occupations associated with high physical activity was associated with reduced risk for PD.…”

Section: Physical Activitymentioning

confidence: 99%

“…48 A unique tea, yerba mate, which is an infusion made from dried, toasted, and milled leaves and stemlets of the Ilex paraguariensis, which is widely consumed in South American countries, was investigated in a case-control study in Argentina and was shown to have a similar risk reduction to conventional tea consumption with an OR of 0.64 (95% CI: 0.54-0.76). 49 Pesticides A recent meta-analysis on the relationship between pesticide use and PD evaluated 39 case-control studies, four cohort studies, and three cross-sectional studies. A summary relative risk of 1.62 (95% CI: 1.4-1.33) for pesticide exposure (ever vs. never) was found.…”

Section: Teamentioning

confidence: 99%

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Epidemiology of Parkinson's Disease—East Versus West

Abbas

Tan

2017

Movement Disord Clin Pract

132

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Background: The cause of PD at present remains unknown. A number of epidemiological studies have been conducted across the globe to ascertain the disease burden and the possible risk factors. In this review, we analyze the various studies from East and West with an aim to observe the important similarities and differences in the disease occurrence and risk factor profile. Methods: A comprehensive search of descriptive and analytical epidemiological studies was undertaken. The descriptive studies and meta-analysis providing the standardised population rates were selected. The demographics, ethnicity and geographical differences between East and West were analysed. In analytical epidemiology, more established and well-studied non-genetic risk factors for PD were reviewed utilising the prospective cohort studies, case control studies and meta-analysis where available. Results and Conclusion: PD is more common with increasing age and shows male predominance, which is more obvious in Western studies. The PD prevalence and incidence rates are slightly lower in the East compared to the West. Incidence studies on different ethnic populations in the same country have also found a lower occurrence of PD amongst Easterners compared to Westerners. Setting methodological differences aside, studies from East and West suggest a role for both environmental and genetic risk factors in PD causation. Smoking, caffeine intake and pesticide exposure are well-established risk factors across regions. There is a robust data for dairy product consumption, urate levels and physical activity in the West while studies on certain risk factors like head injury and alcohol show conflicting and mixed results.Parkinson's disease (PD) is the second most common neurodegenerative disorder and in the majority of cases, its cause remains unknown. Epidemiology refers to the study of distribution and determinants of health related events and their application in the control of diseases. 1In descriptive epidemiology, time, place, and person define the health events; while analytical epidemiology helps to identify and quantify the relationship between exposure and a particular health outcome. 1The epidemiological studies determining race and ethnicity help us to understand the roles of, and interaction between, genetic and environmental factors in disease causation. 2In the present review, we analyze the epidemiological features of PD patients between Western and Eastern countries. The division of East and West is not clear, as the definition varies depending on whether historical, geographical, economic, cultural, or political factors are considered. In this review, we have adopted the cultural definition that considers Asia, and the Middle East as "Eastern" countries; Russia, Europe, the Americas, Australia, and New Zealand as "Western" countries. West studies. In addition, the results of relevant meta-analysis were also discussed.There are a number of PD descriptive epidemiology studies in the literature. The comparison of these studies rem...

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Section: Analytical Epidemiologymentioning

confidence: 99%

Section: Physical Activitymentioning

confidence: 99%

Section: Teamentioning

confidence: 99%

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Epidemiology of Parkinson's Disease—East Versus West

Abbas

Tan

2017

Movement Disord Clin Pract

132

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“…Other authors report that the presence of polyphenols in the YM infusion has a favorable effect on bone tissue and can mitigate the negative effect of caffeine (Brun et al, 2015). It has also been reported that there has been an inverse association between YM infusion consumption and Parkinson's disease (Gatto, Melcon, Parisi, Bartoloni & Gonzalez, 2015). Antiherpes activity was also detected in the crude extract obtained from Ilex paraguariensis leave (Lückemeyer et al, 2012).…”

Section: Introductionmentioning

confidence: 89%

Effects of Ilex Paraguariensis Polyphenols on Magnesium Absortion and Iron Bioavailability: Preliminary Study

Boado¹,

Fretes²,

Brumovsky³

2018

JFR

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Yerba maté (Ilex paraguariensis) is a native plant of South America widely consumed as hot infusion. It is a vegetable that has many bioactive compounds, such as caffeine, theobromine theophylline and saponins, phenolic compounds, mainly chlorogenic acids and dicaffeoylquinic acids, and minerals as Fe, Ca, K y Mg, which have many beneficial properties for the health. Polyphenols have the property of chelating the transition metals, as iron and magnesium, decreasing their bioavailability. Iron deficiency anaemia and subclinical hypomagnesemia is observed in the American population. Women at childbearing age belong to a specially vulnerable group. The aim of this work was to evaluate the "in vivo" effect of the polyphenols from yerba maté infusions, consumed in their traditional form, on the bioavailability of Fe and Mg in the diet. Eleven healhty young female volunteers participated in the magnesium and iron study. After the first blood sample was taken (time 0), the volunteers ingested 300 mL of yerba maté infusions, ferrous sulfate or yerba maté infusions plus ferrous sulfate at50 °C in no more than 5 minutes. They remained seated at a comfortable temperature throughout the study. Blood samples were taken 20, 40, 50, 60, 80, 100 and 120 minutes after ingestion.The yerba maté infusions prepared in their traditional form of "hot maté", which containining an average of 4.68 ± 0.54 GAE/L of polyphenols, have an inhibitory effect on the bioavailability of the magnesium and mainly on non-heminic Fe consumed as ferrous sulphate of the 76 ± 10 % .In Argentina, Paraguay, Brazil and Uruguay Yerba mate consumption is very high, either in the traditional form of hot mate, tea mate in tea bags or cold mate (tereré ). Hot mate consists of putting between 30 and 50 g of yerba mate in a gourd, and a device similar to a straw (bombilla) with a filter on its end is inserted into the yerba mate. Then fractions of approximately 30 mL of hot water (70 º C to 85 º C) are poured repeatedly on the yerba mate, to extract the infusion through the "bombilla". Yerba mate infusions contain a high amount of polyphenols, mainly caffeoylquinic acids.Units and reference values: 1 Globular sedimentation rate (GSR): 0 -15 mm/ 1 er h; 2 Hematocrito: 37 -47 %; 3 Hemoglobin: 11,5 16, 5 g/dL;

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“…The infusion from Ilex paraguariensis (popularly known as Yerba mate [YM]) produces the very popular South American beverage called mate (pronounced as “mate i ” or maté), and its intake has been inversely associated with the development of Parkinson's disease (PD) in a large population study in Argentina . Given that the influence of diet on health (and disease) of the brain is currently a major issue, and the improvement in the tools to detect the signs and symptoms of PD in its prodromal period, it becomes highly relevant to identify and validate potential neuroprotective dietary products that may positively impact on the progression of the disease.…”

mentioning

confidence: 99%