Inverse Association of High-Density Lipoprotein Cholesterol Concentration with Muscle Mass in Children

Duran, İbrahim; Martakis, Κyriakos; Schafmeyer, Leonie; Jackels, Miriam; Rehberg, Mirko; Schöenau, Eckhard

doi:10.1089/chi.2019.0122

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…We found decreased HDL-c levels in the high FMI and the high ALMI-FMI groups. A negative association between HDL-c and ALMI has been previously reported [51,52]. Our study does not only support this finding, but confirms it by age-and sex-adjusted lipid values.…”

Section: Discussionsupporting

confidence: 91%

Using Body Composition Groups to Identify Children and Adolescents at Risk of Dyslipidemia

et al. 2021

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The impact of body composition on the early origin of chronic diseases is an increasingly appreciated phenomenon. Little is known about the characteristics of children with varying body composition. The aim of this study was to investigate serum lipid profiles and other characteristics in relation to body composition. The data of 1394 participants (aged 6 to <18 years) of the observational general population-based Austrian LEAD Study have been analyzed. Body composition groups were defined by appendicular lean mass (ALMI) and fat mass (FMI) indices assessed by DXA. Serum lipid profiles (triglycerides, LDL-c, HDL-c) and other characteristics (e.g., prematurity, smoke exposure, physical activity, nutrition) were investigated in these body composition groups. Different body composition groups, which are not distinguishable by BMI, exist. Children with high ALMI and high FMI showed higher triglycerides and LDL-c, but lower HDL-c levels. In contrast, levels did not differ between those with high FMI but low (or normal) ALMI, and other body composition groups. BMI should be interpreted cautiously, and body composition should be measured by more precise techniques. In particular, children and adolescents with high FMI who have concomitantly high ALMI should be followed closely in future studies to investigate whether they are at increased risk of cardiovascular problems.

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Section: Discussionsupporting

confidence: 91%

Using Body Composition Groups to Identify Children and Adolescents at Risk of Dyslipidemia

et al. 2021

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“…More recently, results from a subset of metabolic healthy adults, participating in the Fels Longitudinal Study, showed that, during the 26 years of follow-up of the study, increases in fat free mass index (FFMI), as well as in FMI, were associated with decreases in HDL-C and increases in TG [ 28 ]. Comparable results were reported also by Duran et al [ 29 ] who showed an inverse association between muscle mass and HDL-cholesterol concentration in a cohort of 6288 children and adolescents, suggesting a counterintuitive, inverse association of muscle mass and HDL-cholesterol concentration [ 29 ].…”

Section: Discussionsupporting

confidence: 77%

Evidence That Skeletal Muscles Modulate HDL-Cholesterol in Metabolic Healthy Young Adults

Lonardo,

Guida,

Cacciapuoti

et al. 2024

Nutrients

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The aim of this study was to investigate whether skeletal muscle (SM) mass correlates with plasma lipids in metabolic healthy young adults. The study was designed as a retrospective observational monocentric study. Data on plasma lipids and SM mass of subjects attending our institution from 1999 to 2014 were analyzed. Inclusion criteria were being 18–45 years old and in apparently good health. SM mass was evaluated by bioelectrical impedance analysis (BIA) using the equation proposed by Janssen and normalized to height as skeletal muscle index (SMI: SM mass/height2). The association between SMI and plasma lipids levels was examined using a crude and adjusted linear regression model including age, sex, BMI and waist circumference as additional covariates. The study population consisted of 450 subjects (273 females) without metabolic syndrome (12.2% with normal body weight, 33.1% overweight, and 54.7% with obesity). SMI, total-cholesterol, LDL-cholesterol, and Triglycerides were higher, whereas HDL-cholesterol was lower in overweight and obese patients as compared with normal weight subjects. SMI was inversely associated with HDL-cholesterol in female patients with obesity but not in male patients with obesity, in normal- or over-weight subjects (p < 0.05). These results suggest that changes in SM mass occurring in obesity could have a role in worsening lipid profile with special reference to HDL-cholesterol.

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“…However, more and more researchers suggested the protective effect of HDL-C in some diseases was overestimated 7 , 18 . Previous research has confirmed that the correlation of HDL-C with muscle mass was also negative among adolescents 13 , 19 . Therefore, HDL-C level might be a potential biomarker for completing the evaluation of skeleton health in adolescents and improving quality of life in the future.…”

Section: Discussionmentioning

confidence: 72%

“…Some studies showed a negative correlation between HDL-C and adult BMD 11 , 12 . Despite Ibrahim Duran et al demonstrated muscle mass inversely correlated with HDL-C level among adolescents 13 , no research clarified and defined the relationship between HDL-C level and BMD value in adolescents. Therefore, exploring the correlation of HDL-C concentration and BMD value would be beneficial for estimating the risk of osteoporosis, which could effectively promote the prevention and treatment of osteoporosis.…”

Section: Introductionmentioning

confidence: 97%

The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study

Wang

Liu

et al. 2023

Sci Rep

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Recent studies have shown a correlation between high-density lipoprotein cholesterol (HDL-C) and bone mineral density (BMD) in adults, but their relationship is unclear in adolescents. This study aimed to explore whether a correlation existed between them among adolescents aged 12–19. Data analyzed in our study was fetched from the National Health and Nutrition Examination Survey (NHANES) database 2011–2018. The relationship between HDL-C level and total BMD value was analyzed by multivariate logistic regression models, fitted smoothing curves, and generalized additive models. 3770 participants participated in this analysis. After adjusting for all relevant covariates involved in this study, we found a negative correlation between HDL-C levels and total bone density in male adolescents.Furthermore, the stratified analysis showed that all covariables-adjusted models retained the negative correlation excepting female, black, or Mexican American subgroups. An inverted U-shaped curve represented the correlation of HDL-C and total BMD among adolescents aged 16 to 19, and the turning point was 1.06 mmol/L. After adjusting for all relevant covariates involved in this study, the study found a negative correlation between HDL-C levels and total BMD in male adolescents aged 12 to 19, particularly among those of races other than Black and Mexican. There was a saturation effect between HDL-C level and total BMD in 16–19-year-old adolescents. The turning point was 1.06 mmol/L. Therefore, HDL-C might be a biomarker to detect bone health and further perform a more detailed examination.

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Inverse Association of High-Density Lipoprotein Cholesterol Concentration with Muscle Mass in Children

Cited by 9 publications

References 46 publications

Using Body Composition Groups to Identify Children and Adolescents at Risk of Dyslipidemia

Using Body Composition Groups to Identify Children and Adolescents at Risk of Dyslipidemia

Evidence That Skeletal Muscles Modulate HDL-Cholesterol in Metabolic Healthy Young Adults

The correlation between high-density lipoprotein cholesterol and bone mineral density in adolescents: a cross-sectional study

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