Inverse associations between muscle mass, strength, and the metabolic syndrome

Atlantis, Evan; Martin, Sean; Haren, Matthew T.; Taylor, Anne; Wittert, Gary

doi:10.1016/j.metabol.2009.02.027

Cited by 241 publications

(171 citation statements)

References 26 publications

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“…All of these indices of physical activity represent physical fitness, and low muscle mass and low muscle strength were the factors strongly associated with increased risk of MetS, independent of insulin resistance, abdominal fat and other risk factors. 35 Not participating in physical activity, even for a short period, may cause a decrease in muscle mass and strength and decrease physical fitness, and is considered to increase the risk of developing MetS.…”

Section: Discussionmentioning

confidence: 99%

Association Between Changes in 12 Lifestyle Behaviors and the Development of Metabolic Syndrome During 1 Year Among Workers in the Tokyo Metropolitan Area

Tajima

Lee

Watanabe

et al. 2014

Circ J

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Section: Discussionmentioning

confidence: 99%

Association Between Changes in 12 Lifestyle Behaviors and the Development of Metabolic Syndrome During 1 Year Among Workers in the Tokyo Metropolitan Area

Tajima

Lee

Watanabe

et al. 2014

Circ J

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“…Lean body mass (LBM) can serve as an index of muscle mass and somatic protein, whereas fat mass more directly reflects energy storage. Higher fat mass has been associated with inflammation and adverse outcomes in the general population (13), whereas higher muscle mass seems to be associated with better clinical outcomes (14). If CKD patients are similar, interventions to improve sarcopenia in CKD patients may improve survival.…”

mentioning

confidence: 99%

Mid-Arm Muscle Circumference and Quality of Life and Survival in Maintenance Hemodialysis Patients

Noori¹,

Kopple²,

Kövesdy³

et al. 2010

Clinical Journal of the American Society of Nephrology

279

198

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Background and objectives: Maintenance hemodialysis (MHD) patients with larger body or fat mass have greater survival than normal to low mass. We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association with clinical outcomes than triceps skinfold (TSF), a surrogate of fat mass.Design, settings, participants, & measurements: The associations of TSF, MAMC, and serum creatinine, another LBM surrogate, with baseline short form 36 quality-of-life scores and 5-year survival were examined in 792 MHD patients. In a randomly selected subsample of 118 subjects, LBM was measured by dual-energy x-ray absorptiometry.Results: Dual-energy x-ray absorptiometry-assessed LBM correlated most strongly with MAMC and serum creatinine. Higher MAMC was associated with better short form 36 mental health scale and lower death hazard ratios (HRs) after adjustment for case-mix, malnutrition-inflammation-cachexia syndrome, and inflammatory markers. Adjusted death HRs were 1.00, 0.86, 0.69, and 0.63 for the first to fourth MAMC quartiles, respectively. Higher serum creatinine and TSF were also associated with lower death HRs, but these associations were mitigated after multivariate adjustments. Using median values of TSF and MAMC to dichotomize, combined high MAMC with either high or low TSF (compared with low MAMC/TSF) exhibited the greatest survival, i.e., death HRs of 0.52 and 0.59, respectively.Conclusions: Higher MAMC is a surrogate of larger LBM and an independent predictor of better mental health and greater survival in MHD patients. Sarcopenia-correcting interventions to improve clinical outcomes in this patient population warrant controlled trials.

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“…Positive changes in body composition may aid in the prevention or treatment of metabolic syndrome as increased skeletal muscle mass may have protective qualities against MS [98]. Rodents fed a low or high RS chow had substantial differences in body composition, favoring the anti-obesity effects of high RS intake [97,99].…”

Section: Prothrombosismentioning

confidence: 99%

Fiber Treating Metabolic Syndrome

Banz

Stamatikos

Deyhim³

et al. 2013

J Metabolic Synd

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The number of individuals diagnosed with metabolic syndrome has risen dramatically in recent years. Although not a disease itself, metabolic syndrome significantly raises the risk of developing cardiovascular disease and type 2 diabetes mellitus, both considered to be epidemics. Therefore, it is critical to promote aggressive therapies that effectively combat conditions associated with the metabolic syndrome. However, treating metabolic syndrome is complicated due to the complex nature of its pathophysiology coinciding with the many health abnormalities metabolic syndrome is often associated with, including but not limited to, insulin resistance, central obesity, hypertension, and atherogenic dyslipidemia. One promising compound that has been demonstrated to alleviate metabolic syndrome is fiber. The various types of fiber work through multiple mechanisms of action in the human body and can potentially result in weight loss in addition to blood glucose control and the lowering of cholesterol. Therefore, increasing intake of dietary fiber might prevent or even reverse some of the negative health anomalies associated with metabolic syndrome. The purpose of this review is to provide a cursory overview of the core components of metabolic syndrome and address how fiber intake may combat these conditions.

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Inverse associations between muscle mass, strength, and the metabolic syndrome

Cited by 241 publications

References 26 publications

Association Between Changes in 12 Lifestyle Behaviors and the Development of Metabolic Syndrome During 1 Year Among Workers in the Tokyo Metropolitan Area

Association Between Changes in 12 Lifestyle Behaviors and the Development of Metabolic Syndrome During 1 Year Among Workers in the Tokyo Metropolitan Area

Mid-Arm Muscle Circumference and Quality of Life and Survival in Maintenance Hemodialysis Patients

Fiber Treating Metabolic Syndrome

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