Inverse lichenoid drug eruption associated with nivolumab

Isolated penile ulceration after Nivolumab therapy for non-small cell lung carcinoma

“…Similar to our patient, she was started on topical steroid ointment 2 to 3 times daily with complete resolution by 2 weeks. 2 …”

“… 1 It is approved by the US Food and Drug Administration for the treatment of metastatic melanoma, refractory non-small cell lung cancer (NSCLC), angiogenesis inhibitor-resistant renal cell carcinoma, and stem cell transplant-resistant classical Hodgkin lymphoma. 2 These medications act via blockade of the PD-1 receptor, which limits immune responses against tumors. Side effects can affect the gastrointestinal tract, liver, endocrine system, and skin.…”

PD1 inhibitor induced inverse lichenoid eruption: a case series

“…Lichenoid reactions secondary to PD1 inhibitors are well documented [1][2][3][4]. However, inverse lichenoid eruption in the groin is a distinct variant that, to our knowledge, has only been reported once [2]. Herein, we describe two additional cases and propose that PD1 inhibitor induced inverse lichenoid eruption (PILE) be recognized as a new entity within the spectrum of adverse cutaneous reactions to immunotherapy agents.…”

“…Atezolizumab was not discontinued secondary to the cutaneous eruption. Table 1 summarizes both these cases along with the previously published case by Guggina et al [2].…”

“…With the emergence of immune checkpoint inhibitors, there have been several reports of cutaneous adverse reactions associated with them [1]. Lichenoid reactions secondary to PD1 inhibitors are well documented [1][2][3][4]. However, inverse lichenoid eruption in the groin is a distinct variant that, to our knowledge, has only been reported once [2].…”