Inverse relationship between vitamin D status and insulin resistance and the risk of impaired fasting glucose in Korean children and adolescents: the Korean National Health and Nutrition Examination Survey (KNHANES) 2009–2010

Chung, Sung Jae; Lee, Young Ah; Hong, Hyunsook; Kang, Min Jae; Kwon, Hyun Jin; Shin, Choong Ho; Yang, Sei Won

doi:10.1017/s1368980013002334

Cited by 27 publications

(42 citation statements)

References 31 publications

(70 reference statements)

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“…Previous clinical studies have shown an inverse association between low vitamin D status and insulin resistance that was independent of total adiposity (BMI and total fat mass) (31)(32)(33)(34)(35). However, this study shows that the inverse relation between vitamin D and insulin resistance is indeed confounded by adiposity, particularly central adiposity.…”

Section: Discussioncontrasting

confidence: 56%

See 1 more Smart Citation

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

Wright

Weinheimer-Haus

Fleet

et al. 2015

The Journal of Nutrition

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Section: Discussioncontrasting

confidence: 56%

“…When controlling for BMI or total fat mass, the association between vitamin D status and insulin resistance continued to persist in some studies (31)(32)(33)(34)(35) but was lost in others (36,37). However, BMI is a measurement of body mass relative to height and does not directly assess total adiposity or its anatomical distribution.…”

Section: Introductionmentioning

confidence: 99%

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

Wright

Weinheimer-Haus

Fleet

et al. 2015

The Journal of Nutrition

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“…Another paper about patients with prediabetes (i. e., impaired fasting glucose or impaired glucose tolerance) reported that individ-uals with the lowest D vitamin concentrations had the highest degree of insulin resistance (using HOMA index) [3]. Similar associations were found also in children and adolescents [32]. In exploratory analysis, after exclusion all subjects with impaired fasting glucose or metabolic syndrome (i. e., those with potentially pre-diabetic state) we confirmed the independent association between D vitamin status and insulin sensitivity.…”

Section: Vitamin D and Impaired Glucose Metabolismmentioning

confidence: 76%

Serum Vitamin D Status, Vitamin D Receptor Polymorphism, and Glucose Homeostasis in Healthy Subjects

et al. 2017

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Low vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA. Subjects were also genotyped for rs2228570 polymorphism of VDR. After adjustment for potential confounders, we observed a significant relationship between 25-OH-D and fasting glycemia (β coefficient=-5.904; p=0.002) or insulin sensitivity (β=0.042; p=0.001), but not with β cell secretion or sRAGE. We found also an interaction with VDR polymorphism. Subjects with low 25-OH-D and genotype had significantly lower insulin sensitivity than those with genotype plus highest 25-OH-D concentrations (107.3% vs. 183.9%, p=0.021). In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with genotype of rs2228570 VDR polymorphism.

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“…Quality evaluation of the articles included showed that the highest score was 18 points and two articles scored this value 39,40 . One article scored 17 points 41 and two articles were quantified with 16 points 42,43 .…”

Section: Methodological Qualitymentioning

confidence: 99%

Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review

Corazza

Tadiotto

Michel

et al. 2019

Rev Bras Ativ Fís Saúde

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This systematic review aimed to synthesize evidence of cross-sectional studies on the associations between physical activity, cardiometabolic risk factors and vitamin D concentrations in children and adolescents. The search was performed in PubMed, SciELO, LILACS, Scopus, MEDLINE and SPORTDiscus. Cardiometabolic risk factors included obesity, insulin resistance, systemic arterial hypertension and unfavorable changes in the lipid profile (low levels of high-density lipoprotein, elevated low-density lipoprotein and triglycerides). Cross-sectional design studies published between 2007 and 2019 were included whether they evaluated the relationship between vitamin D and physical activity and/or vitamin D and cardiometabolic risk factors. Fourteen studies were selected, involving 8340 children and adolescents. The main results found were a significant inverse relationship between vitamin D levels and cardiometabolic risk factors. All studies (n = 8) that tested association between physical activity and 25-hydroxyvitamin D (25 (OH) D) concentrations showed a significant and direct relationship between them. In addition, nine out of eleven studies that tested the association between 25 (OH) D and body mass index reported an inverse and significant relationship between 25 (OH) D and obesity. In conclusion, sufficient concentrations of vitamin D are related to a more favorable cardiometabolic profile, and children and adolescents who are obese or insufficiently active have a higher risk of present hypovitaminosis D.

show abstract

Inverse relationship between vitamin D status and insulin resistance and the risk of impaired fasting glucose in Korean children and adolescents: the Korean National Health and Nutrition Examination Survey (KNHANES) 2009–2010

Cited by 27 publications

References 31 publications

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

The Apparent Relation between Plasma 25-Hydroxyvitamin D and Insulin Resistance Is Largely Attributable to Central Adiposity in Overweight and Obese Adults

Serum Vitamin D Status, Vitamin D Receptor Polymorphism, and Glucose Homeostasis in Healthy Subjects

Association between physical activity, cardiometabolic risk factors and vitamin D in children and adolescents: a systematic review

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