Inverse thermal analysis of the neonatal brain cooling process

Łaszczyk, Joanna; Mączko, Anna; Walas, Wojciech; Nowak, Andrzej J.

doi:10.1108/hff-04-2013-0112

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…The neonate’s body was modeled using MRI and CT images in Mimics software. This study also showed a similar outcome of neonate’s brain cooling as reported in their previous study (Łaszczyk et al, 2014). Pichurov et al (2014) have developed a numerical model to predict the skin temperature distribution because of the airflow inside a room.…”

Section: Introductionsupporting

confidence: 90%

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Influence of external head cooling on the head, core body and blood temperatures using 3D whole-body model

Devarakonda

Bulusu

Al-Rjoub

et al. 2018

HFF

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Purpose The purpose of this study is to evaluate the impact of external head cooling on alleviating the heat stress in the human body by analyzing the temperatures of the core body (Tc), blood (Tblood) and head (Th) during exercise conditions using 3D whole body model. Design/methodology/approach Computational study is conducted to comprehend the influence of external head cooling on Tc, Tblood and Th. The Pennes bioheat and energy balance equations formulated for the whole-body model are solved concurrently to obtain Tc, Tblood and Th for external head cooling values from 33 to 233 W/m2 Increased external head cooling of 404 W/m2 is used to compare the numerical and experimental Th data. Findings Significant reductions of 0.21°C and 0.38°C are observed in Th with external head cooling of 233 and 404 W/m2, respectively. However, for external head cooling of 233 W/m2, lesser reductions of 0.03°C and 0.06°C are found in Tc and Tblood, respectively. Computational results for external head cooling of 404 W/m2 show a difference of 15 per cent in Th compared to experimental values from literature. Originality/value The development of stress because of heat generated within human body is major concern for athletes exercising at high intensities. This study provides an insight into the effectiveness of external head cooling in regulating the head and body temperatures during exercise conditions.

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Section: Introductionsupporting

confidence: 90%

“…Łaszczyk et al (2014) have evaluated the heat transfer during hypothermia therapy of a neonate’s body suffering with hypoxic-ischemic encephalopathy. They modeled the neonate’s body, legs and arms as cylinders and the head as an ellipsoid.…”

Section: Introductionmentioning

confidence: 99%

Influence of external head cooling on the head, core body and blood temperatures using 3D whole-body model

Devarakonda

Bulusu

Al-Rjoub

et al. 2018

HFF

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“…In Wang and Zhu (2007) and Yin et al (2019), both head and neck were modeled. Three-dimensional whole-body models were presented by Łaszczyk et al (2014), Łaszczyk and Nowak (2016), Silva et al (2016) and Bandola et al (2018), some of them with realistic geometries obtained from magnetic resonance imaging. Regarding the cooling technique and device, local brain cooling promoted by surrounding the head with cold water or ice in a cap were considered by Diao and Zhu (2001), Diao et al (2003), Janssen et al (2005), Łaszczyk et al (2014), Łaszczyk and Nowak (2016), Silva et al (2016), Bandola et al (2018), Yin et al (2019) and Nunes et al (2019).…”

Section: Introductionmentioning

confidence: 99%

An inverse analysis of the brain cooling process in neonates using the particle filter method

Nunes

Orlande

Nowak

2022

HFF

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Purpose This study deals with the computational simulation and inverse analysis of the cooling treatment of the hypoxic-ischemic encephalopathy in neonates. A reduced-order model is implemented for real-time monitoring of the internal body temperatures. The purpose of this study is to sequentially estimate the transient temperatures of the brain and other body regions with reduced uncertainties. Design/methodology/approach Pennes’ model was applied in each body element, and Fiala’s blood pool concept was used for the solution of the forward bioheat transfer problem. A state estimation problem was solved with the Sampling Importance Resampling (SIR) algorithm of the particle filter method. Findings The particle filter method was stable and accurate for the estimation of the internal body temperatures, even in situations involving large modeling and measurement uncertainties. Research limitations/implications The proposed reduced-order model was verified with the results of a high-fidelity model available in the literature. Validation of the proposed model and of the solution of the state estimation problem shall be pursued in the future. Practical implications The solution of the state estimation problem with the reduced-order model presented in this paper has great potential to perform as an observer of the brain temperature of neonates, for the analysis and control of the systemic cooling treatment of neonatal hypoxic-ischemic encephalopathy. Social implications The main treatment for hypoxic-ischemic encephalopathy in neonates is the cooling of affected regions. Accurate and fast models might allow the development of individualized protocols, as well as control strategies for the cooling treatment. Originality/value This paper presents the application of the SIR algorithm for the solution of a state problem during the systemic cooling of a neonate for the treatment of the hypoxic-ischemic encephalopathy.

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“…To assist both therapy design and control, attempts are made to use mathematical models of human thermal physiology (i.e. heat transfer and active thermoregulation) [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Natural convection heat transfer coefficient for newborn baby

Ostrowski

Rojczyk

2017

Heat Mass Transfer

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The energy balance and heat exchange for newborn baby in radiant warmer environment are considered. The present study was performed to assess the body dry heat loss from an infant in radiant warmer, using copper cast anthropomorphic thermal manikin and controlled climate chamber laboratory setup. The total body dry heat losses were measured for varying manikin surface temperatures (nine levels between 32.5 • C and 40.1 • C) and ambient air temperatures (five levels between 23.5 • C and 29.7 • C). Radiant heat losses were estimated based on measured climate chamber wall temperatures. After subtracting radiant part, resulting convective heat loses were compared with computed ones (based on Nu correlations for common geometries). Simplified geometry of newborn baby was represented as: (a) single cylinder and (b) weighted sum of 5 cylinders and sphere. The predicted values are significantly overestimated relative to measured ones by: 28.8% (SD 23.5%) for (a) and 40.9% (SD 25.2%) for (b). This showed that use of adopted general purpose correlations for approximation of convective heat losses of newborn baby can lead to substantial errors. Hence, new Nu number correlating equation is proposed. The mean error introduced by proposed correlation was reduced to 1.4% (SD 11.97%), i.e. no significant overestimation. The thermal manikin appears to provide a precise method for the noninvasive assessment of thermal conditions in neonatal care.

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Inverse thermal analysis of the neonatal brain cooling process

Cited by 8 publications

References 11 publications

Influence of external head cooling on the head, core body and blood temperatures using 3D whole-body model

Influence of external head cooling on the head, core body and blood temperatures using 3D whole-body model

An inverse analysis of the brain cooling process in neonates using the particle filter method

Natural convection heat transfer coefficient for newborn baby

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