The multivariable control scheme is a widely used advanced process control methodology to control key process variables in chemical engineering processes. However, successful implementation of multivariable control requires a simplified control structure, a lower number of tuning parameters, and an appropriate tuning method. In this work, a model based multivariable control scheme is realized in reset configuration for the control of stable multi‐input and multi‐output systems. This control scheme utilizes the process transfer function matrix and the inverse of the steady state gain matrix for its implementation. The control scheme has a single tuning parameter and also inherently takes into account the interaction that exists between process inputs and outputs. This scheme is easy to implement and apply in multivariable systems with multiple delays, high‐dimensional systems, non‐square systems, and systems with RHP zeros. Simulation examples from process system engineering such as industrial scale polymerization reactor system, quadruple‐tank system, temperature control for the four room process, and shell control problem are presented to show the efficacy of the proposed multivariable control scheme.