Although the Advocacy Coalition Framework (ACF) emerged in Western democratic contexts, scholars increasingly apply it in other parts of the world to analyze diverse policy topics. These cross-country comparisons have provided a means for advancing comparative research, drawing lessons about policy processes, and offering opportunities to refine the framework. In this paper, we provide an overview of the ACF and its use as an analytical tool for comparative research. Through a systematic literature review, we identified 27 applications in 15 African countries, including democracies, authoritarian governments, and hybrid systems. Based on these applications published in peer-reviewed journals, we explore this illustrated collection of case studies to see how the ACF has been applied outside of Western democracies and to identify strengths and weaknesses of the ACF as a portable framework. These applications confirm the basic postulations of the ACF, but we also identify a few nuances and expectations. Based on these insights, we finally lay out a research agenda and a new generation of questions for applying the ACF in the African context as well as globally.