Investigating in vitro bioactivity, magnetic and mechanical properties of iron and cobalt oxide reinforced (45S5-HA) biocomposite

Prasad, S. K.; Vyas, Vikas Kumar; Harijan, Pappu Kumar; Ershad,; Pyare, Ram

doi:10.1007/s41779-017-0167-y

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…To the best of the authors' knowledge, at present, just two studies have been specifically addressed to proposing Co-doped bioactive glasses to combat cancer. The first one refers to potentially applying magnetic hyperthermia by using 45S5 glass/hydroxyapatite composites containing Fe 2 O 3 and CoO, but no evidence of the functional effect in vitro or in vivo has been reported yet [95]. As regards the photothermal strategy, Liu et al [66] prepared a series of gel-derived SiO 2 -CaO-P 2 O 5 mesoporous glasses doped with 5 mol.% of Co, Cu, Mn and Fe and investigated their antitumor potential under NIR-irradiation in vitro and in vivo after subcutaneous injection of osteosarcoma SAOS-2 cells in mice.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

2023

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Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity of these materials (especially bone-bonding and osteo-stimulatory properties) with the pro-angiogenic effect associated with the release of cobalt. Although the use and local delivery of Co2+ ions into the body have raised some concerns about the possible toxic effects on living cells and tissues, important biological improvements have been highlighted both in vitro and in vivo. This review aims at providing a comprehensive overview of Co-releasing glasses, which find biomedical applications as various products, including micro- and nanoparticles, composites in combination with biocompatible polymers, fibers and porous scaffolds. Therapeutic applications in the field of bone repair, wound healing and cancer treatment are discussed in the light of existing experimental evidence along with the open issues ahead.

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Section: Cancer Treatmentmentioning

confidence: 99%

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

2023

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“…The formation of the hydroxycarbonate apatite layer on the surface of the doped sample immersed in SBF takes place after 14 days, compared to 3-7 days on the undoped sample. The material doped with Fe and Co ions has an improved density and compressive strength compared to the undoped material [233].…”

Section: Doping Agentsmentioning

confidence: 99%

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

Maximov

Crăciun

et al. 2021

Coatings

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Diseases or complications that are caused by bone tissue damage affect millions of patients every year. Orthopedic and dental implants have become important treatment options for replacing and repairing missing or damaged parts of bones and teeth. In order to use a material in the manufacture of implants, the material must meet several requirements, such as mechanical stability, elasticity, biocompatibility, hydrophilicity, corrosion resistance, and non-toxicity. In the 1970s, a biocompatible glassy material called bioactive glass was discovered. At a later time, several glass materials with similar properties were developed. This material has a big potential to be used in formulating medical devices, but its fragility is an important disadvantage. The use of bioactive glasses in the form of coatings on metal substrates allows the combination of the mechanical hardness of the metal and the biocompatibility of the bioactive glass. In this review, an extensive study of the literature was conducted regarding the preparation methods of bioactive glass and the different techniques of coating on various substrates, such as stainless steel, titanium, and their alloys. Furthermore, the main doping agents that can be used to impart special properties to the bioactive glass coatings are described.

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“…Further, excess cations from implanted, which changes pH levels, can also impact tissue regeneration. [30][31][32] Therefore, In-vitro bio-electrochemical analysis is clinical evidence for releasing metal ions from implants, which may link with the tissue engineering process through understanding the corrosion and impedance analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Here, metal ions can bind to proteins and be transported away from the surface of an implant, which can disrupt the equilibrium across the double surface layer generated by the surface electrons. Further, excess cations from implanted, which changes pH levels, can also impact tissue regeneration 30–32 . Therefore, In‐vitro bio‐electrochemical analysis is clinical evidence for releasing metal ions from implants, which may link with the tissue engineering process through understanding the corrosion and impedance analysis.…”

Section: Introductionmentioning

confidence: 99%

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In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis

Savitha,

Surendhiran,

Balu

et al. 2023

Polymers for Advanced Techs

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The work aims for biomimetic fabrication of Moringa oleifera seed (MOS) extract‐mediated cobalt oxide nanoparticles (Co3O4 NPs) with chitosan‐sodium alginate scaffolds by solvent casting. Distinct concentrations of green synthesized Co3O4 nanoparticles were combined to fabricate scaffolds. XRD analysis revealed the cubic structure with an average crystallite size of 18.83 nm. Smaller particle size, spherical morphology, and the presence of organic MOS extract had a substantial impact on the physio‐chemical properties of Co3O4 NPs. In‐vitro bioactivity Co3O4 NPs and nanoparticles anchored scaffolds were determined using simulated body fluid (SBF) through HAP formation. The scaffolds' swelling, protein absorption behavior and bio‐electrochemical analysis were evaluated under PBS. The antibacterial activity of Co3O4 NPs/scaffolds was more effective against Gram‐positive bacterial strains than Gram‐negative ones due to the increased production of ROS. In‐vitro cytotoxicity of the synthesized Co3O4 NPs and scaffolds was tested against the MCF‐7 cell line using an MTT assay. These studies demonstrate that the Co3O4 NPs/scaffolds have excellent physico‐chemical characteristics that increase in‐vitro biocompatibility. Furthermore, impedance and LSV studies showed that biomimetic CSA 200 electrolytes extend host tissue's regenerative compatibility. Also, the anticancer and antibacterial properties of biomimetic scaffold enabled Co3O4 nanoparticles to retain their required biomaterial characteristics for tissue engineering applications.

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Investigating in vitro bioactivity, magnetic and mechanical properties of iron and cobalt oxide reinforced (45S5-HA) biocomposite

Cited by 7 publications

References 44 publications

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis

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Investigating in vitro bioactivity, magnetic and mechanical properties of iron and cobalt oxide reinforced (45S5-HA) biocomposite

Cited by 7 publications

References 44 publications

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

Bioactive Glass—An Extensive Study of the Preparation and Coating Methods

In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co3O4 nanoparticles loaded biomimetic scaffold for preclinical analysis

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Product

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In‐vitro and bio‐electrochemical characteristics of phytochemical enriched Co₃O₄ nanoparticles loaded biomimetic scaffold for preclinical analysis