Investigating perfluorohexane particles with high-frequency ultrasound

Couture, Olivier; Bevan, Peter D.; Chérin, Emmanuel; Cheung, Kevin L.Y.; Burns, Peter N.; Foster, F. Stuart

doi:10.1016/j.ultrasmedbio.2005.09.010

Cited by 57 publications

(52 citation statements)

References 44 publications

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“…Since agglomerated iron oxide nanostructures result in a significantly larger MR signal than the same mass of material dispersed into multiple, smaller units, 89 targeted iron oxide nanoparticles accumulated at a disease site may cooperatively result in an "amplified" signal. Other preclinical examples of nanostructures that may result in amplified imaging signals after accumulation compared to their dispersed forms include perfluorocarbon droplets, which give an enhanced backscatter signal in US imaging, 90 and aggregated gold nanostructures, which result in enhanced photothermal-based imaging and therapy in live cells. 54 Also, as the relaxation properties in Gd-based MRI contrast agents are dependent on their attached ligands and/or surrounding environment, 91 and size and surface effects have been shown to affect the properties of iron-based nanostructures, 92 their aggregation and/or successful attachment to their target may significantly increase their signal such that they could be distinguished from background noise.…”

Section: Iiib Evolution Of Cooperative Nanostructures Systems With mentioning

confidence: 99%

Towards new functional nanostructures for medical imaging

Matsuura

Rowlands

2008

Medical Physics

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Nanostructures represent a promising new type of contrast agent for clinical medical imaging modalities, including magnetic resonance imaging, x-ray computed tomography, ultrasound, and nuclear imaging. Currently, most nanostructures are simple, single-purpose imaging agents based on spherical constructs ͑e.g., liposomes, micelles, nanoemulsions, macromolecules, dendrimers, and solid nanoparticle structures͒. In the next decade, new clinical imaging nanostructures will be designed as multi-functional constructs, to both amplify imaging signals at disease sites and deliver localized therapy. Proposals for nanostructures to fulfill these new functions will be outlined. New functional nanostructures are expected to develop in five main directions: Modular nanostructures with additive functionality; cooperative nanostructures with synergistic functionality; nanostructures activated by their in vivo environment; nanostructures activated by sources outside the patient; and novel, nonspherical nanostructures and components. The development and clinical translation of next-generation nanostructures will be facilitated by a combination of improved clarity of the in vivo imaging and biological challenges and the requirements to successfully overcome them; development of standardized characterization and validation systems tailored for the preclinical assessment of nanostructure agents; and development of streamlined commercialization strategies and pipelines tailored for nanostructure-based agents for their efficient translation to the clinic.

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Section: Iiib Evolution Of Cooperative Nanostructures Systems With mentioning

confidence: 99%

Towards new functional nanostructures for medical imaging

Matsuura

Rowlands

2008

Medical Physics

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“…9 To address these challenges, liquid perfluorocarbon nanodroplets have been proposed as a potential extravascular ultrasound contrast agent. [10][11][12][13][14][15] It is hypothesized that droplets within the size range of a few hundred nanometers can extravasate through leaky microvasculature and accumulate in the tumor interstitial space. Once extravasated, the liquid core of nanodroplets can be vaporized into a gas during the rarefactional cycle of an ultrasonic pressure wave [i.e., acoustic droplet vaporization (ADV)].…”

Section: Introductionmentioning

confidence: 99%

Wideband acoustic activation and detection of droplet vaporization events using a capacitive micromachined ultrasonic transducer

Novell¹,

Arena²,

Oralkan³

et al. 2016

The Journal of the Acoustical Society of America

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An ongoing challenge exists in understanding and optimizing the acoustic droplet vaporization (ADV) process to enhance contrast agent effectiveness for biomedical applications. Acoustic signatures from vaporization events can be identified and differentiated from microbubble or tissue signals based on their frequency content. The present study exploited the wide bandwidth of a 128-element capacitive micromachined ultrasonic transducer (CMUT) array for activation (8 MHz) and real-time imaging (1 MHz) of ADV events from droplets circulating in a tube. Compared to a commercial piezoelectric probe, the CMUT array provides a substantial increase of the contrast-to-noise ratio.

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“…While primarily providing realtime anatomical imaging capabilities, color Doppler mode also enables functional visualization of blood flow, and increasingly quantitative estimates of blood velocities. Microbubbles [3] and perfluorocarbon nanodroplets [4] are being pursued as molecular imaging ultrasound contrast agents, offering potentially very high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer

Zemp¹,

Liu²,

Bitton³

et al. 2008

Opt. Express

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Abstract:We present a novel high-frequency photoacoustic microscopy system capable of imaging the microvasculature of living subjects in realtime to depths of a few mm. The system consists of a high-repetitionrate Q-switched pump laser, a tunable dye laser, a 30-MHz linear ultrasound array transducer, a multichannel high-frequency data acquisition system, and a shared-RAM multi-core-processor computer. Data acquisition, beamforming, scan conversion, and display are implemented in realtime at 50 frames per second. Clearly resolvable images of 6-μm-diameter carbon fibers are experimentally demonstrated at 80 μm separation distances. Realtime imaging performance is demonstrated on phantoms and in vivo with absorbing structures identified to depths of 2.5-3 mm. This work represents the first high-frequency realtime photoacoustic imaging system to our knowledge.

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Investigating perfluorohexane particles with high-frequency ultrasound

Cited by 57 publications

References 44 publications

Towards new functional nanostructures for medical imaging

Towards new functional nanostructures for medical imaging

Wideband acoustic activation and detection of droplet vaporization events using a capacitive micromachined ultrasonic transducer

Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer

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