Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Hartberg, Cecilie B.; Lawyer, Glenn; Nyman, Håkan; Jönsson, Erik G.; Haukvik, Unn K.; Saetre, Peter; Bjerkan, Petr S; Andreassen, Ole A.; Hall, Håkan; Agartz, Ingrid

doi:10.1016/j.pscychresns.2010.01.001

Cited by 73 publications

(56 citation statements)

References 234 publications

(235 reference statements)

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“…37 The only other published study comparing relationships between cortical thickness and cognitive performance in patients with schizophrenia spectrum disorder (n = 67) and HCs (n = 62) found similar relationships of cortical thickness with verbal learning and executive functioning but a diminished association between thickness in temporo-occipital areas and verbal fluency in patients compared with HCs. 34 Although in this study the discrepancies between patients and controls were less pronounced (which may be due to a different statistical model which uses a 2-step approach to constrain the search space for the final analyses), the authors also interpret their findings as a disruption of structure-function relationships in schizophrenia patients.…”

Section: Working Memory and Cortical Thickness In Associated Brain Rementioning

confidence: 67%

“…[29][30][31][32][33] A recent investigation also revealed verbal learning to be related to cortical thickness of the superior and middle frontal gyrus for both schizophrenia and control subjects, but verbal processing and executive functioning showed similar across group associations with thickness of frontal cortical regions. 34 In the same study, cortical thickness of temporal regions was found to be related to verbal learning, verbal processing, and executive functioning, with only an association between verbal processing and temporaloccipital gyrus being unique to schizophrenia. Thus, cognitive functions that are dependent on temporal and frontal lobes appear to be most related to aspects of cortical thinning in schizophrenia, but the unique effects of the disorder on the function-structure relationship are largely unknown.…”

Section: Introductionmentioning

confidence: 91%

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Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

Ehrlich

Brauns

Yendiki

et al. 2011

Schizophrenia Bulletin

159

100

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Previous studies have found varying relationships between cognitive functioning and brain volumes in patients with schizophrenia. However, cortical thickness may more closely reflect cytoarchitectural characteristics than gray matter density or volume estimates. Here, we aimed to compare associations between regional variation in cortical thickness and executive functions, memory, as well as verbal and spatial processing in patients with schizophrenia and healthy controls (HCs). We obtained magnetic resonance imaging and neuropsychological data for 131 patients and 138 matched controls. Automated cortical pattern matching methods allowed testing for associations with cortical thickness estimated as the shortest distance between the gray/white matter border and the pial surface at thousands of points across the entire cortical surface. Two independent measures of working memory showed robust associations with cortical thickness in lateral prefrontal cortex in HCs, whereas patients exhibited associations between working memory and cortical thickness in the right middle and superior temporal lobe. This study provides additional evidence for a disrupted structure-function relationship in schizophrenia. In line with the prefrontal inefficiency hypothesis, schizophrenia patients may engage a larger compensatory network of brain regions other than frontal cortex to recall and manipulate verbal material in working memory.

show abstract

Section: Working Memory and Cortical Thickness In Associated Brain Rementioning

confidence: 67%

Section: Introductionmentioning

confidence: 91%

Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

Ehrlich

Brauns

Yendiki

et al. 2011

Schizophrenia Bulletin

159

100

View full text Add to dashboard Cite

show abstract

“…In 87 participants aged 20 to 77 years, Raz et al [2008] observed that, after accounting for the effects of age, sex, and vascular risk factors, the orbitofrontal cortex and the prefrontal white-matter volumes as well as the 5-year change in entorhinal cortex volume predicted fluid intelligence level, assessed by Cattell Culture Fair Intelligence and Letter Sets tests. Hartberg et al [2010] found that thicker cortex in superior temporal, superior frontal, and inferior frontal gyri was related to fewer perseverative errors in the WCST among schizophrenic patients and healthy adults 20-56 years old. Elderkin-Thompson et al [2008] found both positive and negative correlations between volume of the frontal lobe gyri and various executive function scores in adults aged 61-88 years.…”

Section: Introductionmentioning

confidence: 87%

Cortical thickness is linked to executive functioning in adulthood and aging

Burzyńska¹,

Nagel²,

Preuschhof³

et al. 2011

Human Brain Mapping

124

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Executive functions that are dependent upon the frontal-parietal network decline considerably during the course of normal aging. To delineate neuroanatomical correlates of age-related executive impairment, we investigated the relation between cortical thickness and executive functioning in 73 younger (20-32 years) and 56 older (60-71 years) healthy adults. Executive functioning was assessed using the Wisconsin Card Sorting Test (WCST). Cortical thickness was measured at each location of the cortical mantle using surface-based segmentation procedures on high-resolution T1-weighted magnetic resonance images. For regions involved in WCST performance, such as the lateral prefrontal and parietal cortices, we found that thicker cortex was related to higher accuracy. Follow-up ROI-based analyses revealed that these associations were stronger in older than in younger adults. Moreover, among older adults, high and low performers differed in cortical thickness within regions generally linked to WCST performance. Our results indicate that the structural cortical correlates of executive functioning largely overlap with previously identified functional patterns. We conclude that structural preservation of relevant brain regions is associated with higher levels of executive performance in old age, and underscore the need to consider the heterogeneity of brain aging in relation to cognitive functioning. Hum Brain Mapp 33:1607-1620,

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“…65 The mechanism through which ANK3 could impact cortical thickness is not fully clear. ANK3 promotes the propagation of action potentials, 27 and some researchers have posited that decreased ANK3 expression in patients with schizophrenia could reduce pyramidal cell activation in the cortex.…”

mentioning

confidence: 99%

Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis

Cassidy

Buchy

Bodnar

et al. 2014

J Psychiatry Neurosci

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Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults

Cited by 73 publications

References 234 publications

Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

Associations of Cortical Thickness and Cognition in Patients With Schizophrenia and Healthy Controls

Cortical thickness is linked to executive functioning in adulthood and aging

Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis

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