Investigating the Apoptosis Ability of Ethylenediamine 8-Hydroxyquinolinato Palladium (II) Complex

Abstract

IntroductionAlthough cisplatin is mainly utilized for treatment of various cancers such as ovarian, breast, stomach and prostate, its side effects and its drug resistance have led to more research for synthesis of new and nontoxic derivatives of platinum-group metals.1 Among the close elements of platinum in the periodic table, palladium complexes have high solubility and low renal toxicity; so several palladium complexes with different ligands such as phenanthroline derivatives, N-heterocyclic carbenes, Schiff bases etc were synthesized.2-4 One of the donor and lipophilic chelating ligands is 8-Hydroxyquinoline (8HQ), a multifunctional ligand, that possess therapeutic and antioxidant properties. It can act as a potent chelator for restoring metal balance, when the diseases are related to metal imbalance.5 Moreover, it can form a planar complex with palladium and thus complex can intercalate between DNA strands. In another mechanism, 8HQ metal complexes can facilitate the membrane damage, DNA cleavage and apoptotic cell death in tumors.

Etil Piruvatın Çeşitli Kanser Hücre Hatları Üzerindeki Sitotoksik Etkisinin İncelenmesi

“…Consistent with these results, it is reported that the IC50 values of CDDP on HeLa and A549 cell lines vary between 0.75 to 8.6 µM (Gumus et al, 2009;Casagrande et al, 2013;Singh et al, 2015) and 1.12 to 7 µM (Adach et al, 2016;Jin et al, 2019;Zhang et al, 2020), respectively. Similarly, it is reported that the IC50 values of CDDP on MCF-7 and HepG2 cell lines vary between 3.09 to 12.5 µM (Aung et al, 2007;Gumus et al, 2009;Mansouri-Torshizi et al, 2016) and 7.75 to 24.1 µM (Sakinah et al, 2007;Adach et al, 2016;Hashiesh et al, 2018), respectively. In parallel with these results, it is reported that the IC50 values of CDDP on WiDr and BJ cell lines vary between 1.2 to 6 µM (Temmink et al, 2007;Turan et al, 2018;van Zweeden et al, 2018) and 13 to 20 µM, (Adach et al, 2016;Col Ayvaz et al, 2017;Varbanov et al, 2019), respectively.…”

Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives

“…Several common drugs with thiazole core such as tiazofurin and dasatinib are utilized in chemotherapy [29,30]. Accordingly, we synthesized thiazoles 5 and 7, and evaluated them on MCF-7 breast cancer cells.…”

Hyaluronic acid/polyethylene glycol nanoparticles for controlled delivery of mitoxantrone

“…The in vitro cytotoxicity analysis of MTX-EDA-PEG-EDA-HA NPs and free MTX against two cell lines with different levels of CD44 expression (MDA-MB-231 (very high) and MCF-7 (low)) [16,17] was conducted by MTT assay. The cells were cultured in RPMI 1640 media supplemented with 10% FBS and 100 lL of penicillin G/streptomycin mixture at 37 C in a humidified CO 2 incubator [18,19]. Cell passaging was done by trypsinization.…”