A geographic information system (GIS) stores, manipulates, analyses, and visualises spatial data. GIS enables the mapping of building elements and components and can optimise the location of facilities for circular activities, thus contributing to the closing of material loops and the spatial development of circular cities and regions. This chapter presents use cases of GIS in the circular built environment, with examples from academia, industry, and government. Academics use GIS data for urban mining studies to estimate the location and availability of secondary construction materials. Businesses in industry use GIS analysis to inform the facility location of circular construction hubs and (reverse) logistics. Governments use GIS to monitor and assess the circular spatial development potential of their (industrial) territories. In order to integrate GIS into circular economy solutions, improvements need to be made in making spatial data available and in presenting findings that emerge from it. Finally, present enthusiasm for GIS tools should be balanced by a deeper understanding of the connection between digital tools and governance decisions.