Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

“…[18][19][20] Examples of using MRI in quantitative and non-invasive studies of solid dosage forms include investigating events during the dissolution process, [21][22][23][24][25] identifying relationships between dissolution and formulation parameters [26][27][28][29] and mapping of tablet porosimetry. [30][31][32][33] MRI has also been used to correlate drug release profiles with dissolution events for the tablet being examined ex situ 34 and in situ in the dissolution equipment. 35,36 In addition, magnetic markers have been used to monitor the location and transit velocities of tablets when in vivo and correlated to dissolution measured by plasma concentrations.…”

Oral pulsatile delivery: Rationale and chronopharmaceutical formulations

“…Impermeable Bar-Shalom et al, 2009;Binns et al, 1996;Gohel and Sumitra, 2002;Hebden et al, 1999;Krögel andBodmeier, 1998, 1999b;Lee et al, 2000;Mastiholimath et al, 2007;McConville et al, 2004McConville et al, , 2005McConville et al, , 2009Nayak et al, 2009;Ross et al, 2000;Stevens et al, 2002;Sutch et al, 2003;Wilding et al, 1992Semi-permeable Crison et al, 1996Löbenberg et al, 2005 (d) Release controlling plug:…”

“…Swellable Binns et al, 1996;Hebden et al, 1999;Stevens et al, 2002;Wilding et al, 1992 Swellable/erodible Bar-Shalom et al, 2009;Gohel and Sumitra, 2002;Krögel andBodmeier, 1998, 1999b;Lee et al, 2000;Mastiholimath et al, 2007;McConville et al, 2004McConville et al, , 2005McConville et al, , 2009Nayak et al, 2009;Ross et al, 2000;Sutch et al, 2003Hydrophobic Crison et al, 1996Löbenberg et al, 2005 (e) Optional immediate-release drug dose Crison et al, 1996;Löbenberg et al, 2005 in delaying the drug liberation (McConville et al, 2004). Moreover, notable differences were found in the performance of such erosion-based capsular systems when the impermeable EC film was applied by aqueous rather than organic spray-coating to the drug-containing body (Sutch et al, 2003;McConville et al, 2005).…”

“…Moreover, notable differences were found in the performance of such erosion-based capsular systems when the impermeable EC film was applied by aqueous rather than organic spray-coating to the drug-containing body (Sutch et al, 2003;McConville et al, 2005). Superior mechanical properties upon exposure to high-moisture conditions and a better release control related to a tighter plug seal were indeed observed in the case of organic film-coated capsules.…”

Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: A technical note

“…The application of MRI in the field of pharmaceutical technology has been reported in several papers. [4][5][6][7][8] Fyfe et al 9 described the system for performing MRI experiments within US Pharmacopeia apparatus 4. The system was applied to record the physical changes of the tablets simultaneously with the dissolution study.…”