Investigating the effects of fatigue on blood glucose levels – Implications for diabetes

Beehan-Quirk, Curtis; Jarman, L; Maharaj, Shamona; Simpson, Ann M.; Nassif, Najah T.; Lal, Sara

doi:10.1016/j.tmsr.2020.03.001

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Significant improvements of up to greater than 24% were observed in the CIS scores within the RiaGev group, whereas the improvements in the placebo group did not reach significant level in any category. Like a previous analysis [ 43 ], a positively correlation was found between total CIS score and fasting blood glucose (r = 0.952). Meanwhile a negatively correlation was noticeable between total CIS score with NAD+ concentration (r = −0.849).…”

Section: Discussionsupporting

confidence: 77%

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

et al. 2022

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Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor required for proper functioning of all cells and its decline is correlated with advancing age and disease. This randomized, triple-blind, placebo-controlled, crossover pilot study assessed the efficacy and safety of a combination of nicotinamide with D-ribose (RiaGev) for NAD metabolome enhancement and related benefits in healthy middle-aged adults. Supplementing with 1520 mg RiaGev twice daily for 7 days significantly increased the NAD+ metabolome in blood, especially NADP+ by 27% compared to the placebo group (p = 0.033) and over the baseline (p = 0.007). Increases in glutathione and high energy phosphates were also observed in the blood. Seven-day supplementation with RiaGev significantly (p = 0.013) reduced overall blood glucose without significant changes in insulin secretion (p = 0.796), suggesting an improved insulin sensitivity and glucose tolerance. The waking salivary cortisol of the subjects steadily and significantly decreased (p = 0.026) in the RiaGev group in contrast to the placebo. Subjects in the RiaGev group showed less fatigue, improved mental concentration and motivation over the baseline (p = 0.015, 0.018, and 0.012, respectively) as observed through the Checklist Individual Strength (CIS) questionnaire. There were no clinically relevant adverse events, or alterations in hematology, electrolytes, liver, and kidney markers pre- and post-supplementation. RiaGev appears to be safe and efficacious in increasing NAD+ metabolome in healthy middle-aged adults, as shown by this study.

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Section: Discussionsupporting

confidence: 77%

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

et al. 2022

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“…Diabetes fatigue is closely associated with distress conditions and psychological changes in patients with DM [ 33 ]. This can have an impact on the levels of HbA1c [ 34 ], TAS, insulin [ 35 ], and lipid profiles [ 36 , 37 ]. A condition of less-than-normal insulin levels can have an impact on glycolysis, decrease the rate of adenosine diphosphatase phosphorylation, and slow down adenosine triphosphatase resistance, which could, in turn, lead to diabetes fatigue.…”

Section: Discussionmentioning

confidence: 99%

Resilience-based Islamic program as a promising intervention on diabetes fatigue and health-related quality of life

et al. 2022

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Psychological problems commonly experienced by patients with type 2 diabetes mellitus (T2DM) cause diabetes fatigue conditions that can further worsen the treatment prognosis. We conducted this investigation to determine the effectiveness of a resilience-based Islamic program on diabetes fatigue and health-related quality of life (HRQoL) by measuring the biochemical indicators of T2DM. This was a quasi-experimental study performed from May to August 2021, in which 80 respondents aged 18–64 years diagnosed with T2DM were included through purposive sampling at a male:female sex ratio of 1:1 in the control group and 17:23 in the treatment group. A resilience-based Islamic program (a combination of stress management, mindfulness, prayer, and dhikr (the ritual formula of Sufi brotherhood recited devotionally in praise of Allah and as a means of attaining ecstatic experience)) was implemented in the treatment group for six sessions by blended online and offline interventions. Multidimensional Fatigue Inventory-20 and World Health Organization Quality of Life, Brief Form were used to evaluate diabetes fatigue and HRQoL. Blood tests were performed to measure HbA1c, total antioxidant serum, insulin, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) levels from baseline to 3 months. Statistical analyses were conducted using paired t test, Wilcoxon signed-rank test, independent t test, and Mann–Whitney U test. The resilience-based Islamic program had a beneficial impact on the levels of HbA1c (p < 0.001), lipid profile (triglyceride) (p = 0.011), HDL-c (p = 0.01), LDL-c (p < 0.001), total antioxidant serum (p = 0.001), insulin (p < 0.001), diabetes fatigue (p < 0.05), and HRQoL (p < 0.05) in patients of the treatment group. The results of biochemical tests related to T2DM also indicated a reduction in diabetes fatigue and an increase in HRQoL due to the resilience-based Islamic program. Considering that a patient’s resilience to diabetes is an important factor in the management of diabetes fatigue, the resilience-based Islamic program can be applied at public health centers and community levels to increase T2DM resilience.

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“…Every year 1.5 million Australian visits doctors with the complain of diabetes related fatigue. 18 Evidence shows that diabetes related fatigue adversely affects QOL of diabetic patient and diminish their self-management abilities towards diabetes and experienced physical difficulties like body pain, weakness in lower extremities, functional muscle loss, poor reflexes etc. Though, the link between fatigue and diabetes is not yet completely understood.…”

Section: Impact Of Diabetes On Various Domain Of Quality Of Lifementioning

confidence: 99%

Diabetes, A Culprit Against Quality of Life?

Mohanty¹,

Saini

2022

Natl J Community Med

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Quality of life (QoL) is a very contemporary domain of modern health care practices. Though it has no clear or concise definition, its impact of it is huge for an individual living with diabetes mellitus. Yet, the mention of QoL is restricted to majorly four common domains, such as physical, psychological, social, and environmental, which excludes the major areas that lead to poor QoL among diabetic individuals in rural India, such as, indefinite food restriction and seclusion from the family dining menu or isolation from festivals largely focused on food. Work and role limitation in the Indian setting is also a prevalent precursor to poor QoL, for example, the consciousness of frequent bathroom visits due to polyuria, unaffordability of proper storage of insulin in the workplace, and increased absenteeism for doctor visits. The focus on the vague ideas of QoL needs to be changed towards more individualistic, as it is a subjective measure. Nonetheless, the assessment of QoL is non-existent in the treatment protocols of diabetes in rural India, mostly because of the non-availability of specialized institutions, resources, and services. Moreover, as diabetes is a silent disease, the effects of self-care are not immediate, even though, long-term benefits have been proven, leading to poor motivation added to inaccessibility of healthcare services, creating an environment for detrimental quality of life. Thus, an individualist approach toward QoL is warranted along with mandatory evaluation of QoL in every area of the diabetic therapeutic regime.

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Investigating the effects of fatigue on blood glucose levels – Implications for diabetes

Cited by 5 publications

References 28 publications

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

Resilience-based Islamic program as a promising intervention on diabetes fatigue and health-related quality of life

Diabetes, A Culprit Against Quality of Life?

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