In the 2013 curriculum subjects in primary schools were organized with themes, namely combining all subjects that reflect students’ everyday lives. However, the themes in the student’s book do not integrate one subject with the others and do not reflect the students real life. Therefore, it is hard for many primary school teachers in Padang to implement the integrated learning using the textbooks. This research aims to develop the interactive e-module based on the principles of integrated learning that can facilitate students in carrying out learning process, so it can improve students’ competency. The research and development of interactive e-module use four-D models that consist of four stages, namely define, design, develop and disseminate. The research subject was the interactive e-module based on integrated learning. The respondents of this research were 12 teachers and 70 Grade 5 students of three primary schools in Padang, West Sumatra, Indonesia. Data were collected using observation sheets, interview guides, questionnaires, and tests. There are three main results obtained from the research. First, according to expert judgment the interactive e-module is valid. Second, based on teacher and student's responses the module is very practical. Third, based on the student learning outcomes the interactive e-module is effective.