Investigating the effects of vitamins E and C on oxidative stress and hematological parameters among power plant workers: A double-blind randomized controlled clinical trial

Abstract

The present study aimed to determine the effect of taking antioxidant vitamins including vitamins E and C in reducing oxidative stress levels and improving blood parameters. This double-blind randomized controlled trial study was conducted among the employees working in different parts of a power plant in Semnan, Iran, in 2017. A total of 91 employees were randomly allocated to four groups including vitamin E (400 units per day), vitamin C (1000 mg per day), vitamin E + C for 90 days, and control. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (Cat), and total antioxidant capacity (TAC) in plasma, and hematological parameters were measured in the participants before and after the intervention. A significant increase was seen in the mean level of SOD, Cat, and TAC in the vitamin-treated groups as well as a significant decrease in mean MOD in vitamin C and vitamin E groups after the intervention. In the intervention groups, the number of red blood cells, hematocrit, and the level of mean corpuscular hemoglobin (MCH) and MCH concentration significantly increased. After the intervention, the mean levels of MDA, SOD, and Cat in vitamin E group were significantly lower than the control group. The mean level of TAC decreased only in the vitamin C group compared to the control group. Taking vitamins E and C as nonenzymatic scavengers of free radicals appears to decrease lipid peroxidation and increase the level of antioxidant enzymes, which can be imbalanced by exposure to extremely low-frequency electromagnetic fields in power plant employees. Furthermore, some hematological parameters can be improved by consuming these vitamins.

Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress

“…The fact that Vitamins C and E treatment in CVS rats resulted in the contrast suggests that the combination of Vitamins C and E administered improved antioxidant enzymes ability, endocrine function, and reduce lipid peroxidation in oxidative stress. This result was similar to those of several previous studies [35,36]. Increased antioxidant enzyme activities may be considered as a protective mechanism against stress-induced free radical production and lipid peroxidation [37].…”

Role of Nanoparticle-Conjugates and Nanotheranostics in Abrogating Oxidative Stress and Ameliorating Neuroinflammation

“…Vitamin C and E improved antioxidant enzymes and reduced free radicals in a rat model with repetitive loading exercise as well as aging [138]. Employees of a power plant where they are routinely exposed to extremely low-frequency electromagnetic fields, which is known to cause oxidative damage, showed a declining trend of lipid peroxidation with an enhancement in the level of antioxidant enzymes after supplementation of vitamin C (1000 mg) and E (400 units) every day for 90 days [139]. Vitamin E is a known antioxidant and is ubiquitously present in vegetables.…”