Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification

Jain, Varsha; Abdulmalik, Osheiza; Propert, Kathleen J.; Wehrli, Félix W.

doi:10.1002/mrm.23282

Cited by 108 publications

(155 citation statements)

References 30 publications

Supporting

Mentioning

146

Contrasting

Order By: Relevance

“…CBV v is the venous blood volume fraction, estimated as 77% of total cerebral blood volume (CBV) (32); and X dH; mol ¼ 151:054 ppb mL=mmol X dH; mol ¼ 151:054 ppb mL=mmol is the molar magnetic susceptibility of dH (11,12).…”

Section: Reconstruction Of Cmro 2 and Oefmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Zhang

Cho

Zhou

et al. 2017

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose: The objective of this study was to demonstrate the feasibility of a cerebral metabolic rate of oxygen (CMRO 2 ) mapping method based on its minimum local variance (MLV) without vascular challenge using quantitative susceptibility mapping (QSM) and cerebral blood flow (CBF). Methods: Three-dimensional multi-echo gradient echo imaging and arterial spin labeling were performed in 11 healthy subjects to calculate QSM and CBF. Minimum local variance was used to compute whole-brain CMRO 2 map from QSM and CBF. The MLV method was compared with a reference method using the caffeine challenge. Their agreement within the cortical gray matter (CGM) was assessed on CMRO 2 and oxygen extraction fraction (OEF) maps at both baseline and challenge states. Results: Mean CMRO 2 (in mmol/100 g/min) obtained in CGM using the caffeine challenge and MLV were 142 6 16.5 and 139 6 14.8 mmol/100 g/min, respectively; the corresponding baseline OEF were 33.0 6 4.0% and 31.8 6 3.2%, respectively. The MLV and caffeine challenge methods showed no statistically significant differences across subjects with small ( < 4%) biases in CMRO 2 and OEF values. Conclusions: Minimum local variance-based CMRO 2 mapping without vascular challenge using QSM and arterial spin labeling is feasible in healthy subjects. Magn Reson Med 79:172-179,

show abstract

Section: Reconstruction Of Cmro 2 and Oefmentioning

confidence: 99%

“…Unlike R 2 and R Ã 2 , the relationship between [dH] and tissue susceptibility is linear in its concentration and independent of imaging parameters (11)(12)(13). Hence, QSM can be used to quantify oxygenation in large veins (14)(15)(16)(17)(18) and in tissue (19,20).…”

Section: Introductionmentioning

confidence: 99%

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Zhang

Cho

Zhou

et al. 2017

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…The accuracy of MRI-measured S v O 2 quantification depends on Dw do , which has been previously determined using healthy adult blood. 17,45 It is plausible that this constant might differ slightly for fetal blood given the presence of fetal Hb. However, it is unlikely that the inherent paramagnetism of heme iron in its deoxy state in fetal Hb is substantially different from that in adult Hb as the two Hb types differ only in the type of globin chains present.…”

Section: Limitationsmentioning

confidence: 99%

Cerebral Oxygen Metabolism in Neonates with Congenital Heart Disease Quantified by MRI and Optics

Jain

Buckley

Licht

et al. 2013

J Cereb Blood Flow Metab

Self Cite

173

192

View full text Add to dashboard Cite

Neonatal congenital heart disease (CHD) is associated with altered cerebral hemodynamics and increased risk of brain injury. Two novel noninvasive techniques, magnetic resonance imaging (MRI) and diffuse optical and correlation spectroscopies (diffuse optical spectroscopy (DOS), diffuse correlation spectroscopy (DCS)), were employed to quantify cerebral blood flow (CBF) and oxygen metabolism (CMRO 2 ) of 32 anesthetized CHD neonates at rest and during hypercapnia. Cerebral venous oxygen saturation (S v O 2 ) and CBF were measured simultaneously with MRI in the superior sagittal sinus, yielding global oxygen extraction fraction (OEF) and global CMRO 2 in physiologic units. In addition, microvascular tissue oxygenation (StO 2 ) and indices of microvascular CBF (BFI) and CMRO 2 (CMRO 2i ) in the frontal cortex were determined by DOS/DCS. Median resting-state MRI-measured OEF, CBF, and CMRO 2 were 0.38, 9.7 mL/minute per 100 g and 0.52 mL O 2 /minute per 100 g, respectively. These CBF and CMRO 2 values are lower than literature reports for healthy term neonates (which are sparse and quantified using different methods) and resemble values reported for premature infants. Keywords: cerebral blood flow; cerebral hemodynamics; diffuse optics; MRI; near-infrared spectroscopy; neonatal ischemia INTRODUCTION Congenital heart disease (CHD) affects B35,000 neonates each year in the United States. These patients suffer both short-and long-term neurologic sequelae. Periventricular leukomalacia is the most common cerebral injury found in this population. This type of injury is characterized by focal necrosis in the periventricular white matter, and it is associated with pyknotic glial nuclei and reactive gliosis. 1,2 During the early stages of brain development, the oligodendrocyte (brain glial cells) precursors are metabolically very active and highly susceptible to injury from reduced blood flow and oxygen delivery. Hence, hypoxiaischemia has been implicated as a major cause of this injury in CHD neonates.Periventricular leukomalacia leads to impaired myelination and has been linked to worse neurodevelopmental outcomes in premature infants and postulated to cause (at least in part) the impaired cognition and cerebral palsy commonly seen in this cohort of infants with CHD. 3,4 Quantification of the hemodynamic and metabolic state of these neonates via measurements of cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen consumption (CMRO 2 ) should provide valuable information toward understanding the interaction between cardiac pathophysiology and subsequent cerebral health. Potentially, such new knowledge could help predict and prevent adverse outcomes.

show abstract

“…(cgs) was the susceptibility shift per unit Hct between fully deoxygenated and fully oxygenated blood. 26 Blood Hct was measured in 16 patients within 4 months of the MRI scan, and assumed to be 42% in all remaining subjects.…”

Section: Data Processing For Oxygen Extraction Fraction Quantificationmentioning

confidence: 99%

Quantitative Oxygen Extraction Fraction from 7-Tesla MRI Phase: Reproducibility and Application in Multiple Sclerosis

Fan

Govindarajan

Kinkel

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic resonance imaging (MRI) phase images at 7 Tesla (7 T). Flow-compensated, three-dimensional gradient-echo scans were acquired for absolute OEF quantification in 23 patients with MS and 14 age-matched controls. In patients, we collected T2*-weighted images for characterization of white matter, deep gray matter, and cortical lesions, and also assessed cognitive function. Variability of OEF across readers and scan sessions was evaluated in a subset of volunteers. OEF was averaged from 2 to 3 pial veins in the sensorimotor, parietal, and prefrontal cortical regions for each subject (total of~10 vessels). We observed good reproducibility of mean OEF, with intraobserver coefficient of variation (COV) = 2.1%, interobserver COV = 5.2%, and scan-rescan COV = 5.9%. Patients exhibited a 3.4% reduction in cortical OEF relative to controls (P = 0.0025), which was not different across brain regions. Although oxygenation did not relate with measures of structural tissue damage, mean OEF correlated with a global measure of information processing speed. These findings suggest that cortical OEF from 7-T MRI phase is a reproducible metabolic biomarker that may be sensitive to different pathologic processes than structural MRI in patients with MS.

show abstract

Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification

Cited by 108 publications

References 30 publications

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Cerebral Oxygen Metabolism in Neonates with Congenital Heart Disease Quantified by MRI and Optics

Quantitative Oxygen Extraction Fraction from 7-Tesla MRI Phase: Reproducibility and Application in Multiple Sclerosis

Contact Info

Product

Resources

About