Investigating the microRNA signature of ANCA associated vasculitis

Brown, Nina; Harris, S.; Venning, Michael; Brenchley, P

doi:10.1016/j.lpm.2013.02.247

“…Pooled plasma samples from 40 patients who had active ANCA vasculitis or were in remission showed up-regulation of hsa-let-7f-5p and hsa-miR-424-5p, and downregulation of hsa-miR-106b, hsa-miR-9-5p, hsa-miR-125a-50, and hsa-miR-15b-5p [ 87 ]. These miRNAs regulate various aspects of the immune system [ 87 ], suggesting a direct role in the development of clinical disease.…”

Section: Mirnas In Select Renal Parenchymal Diseasesmentioning

confidence: 99%

Role of MicroRNAs in Renal Parenchymal Diseases—A New Dimension

Shaffi

¹

,

Galas

²

,

Etheridge

³

et al. 2018

IJMS

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Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.

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“…These miRNAs regulate various aspects of the immune system [85], suggesting a direct role in the development of clinical disease. miR-155 is upregulated in patients with ANCA-associated crescentic GN.…”

Section: Anti-neutrophilic Cytoplasmic Antibodies Associated Vasculitmentioning

confidence: 99%

Role of microRNAs in Renal Parenchymal Diseases—A New Dimension

Shaffi¹,

Galas²,

Etheridge³

et al. 2018

Preprint

4

0

View full text Add to dashboard Cite

Since their discovery in 1993, numerous microRNAs (miRNAs) have been identified in humans and other eukaryotic organisms, and their role as key regulators of gene expression is still being elucidated. It is now known that miRNAs not only play a central role in the processes that ensure normal development and physiology, but they are often dysregulated in various diseases. In this review, we present an overview of the role of miRNAs in normal renal development and physiology, in maladaptive renal repair after injury, and in the pathogenesis of renal parenchymal diseases. In addition, we describe methods used for their detection and their potential as therapeutic targets. Continued research on renal miRNAs will undoubtedly improve our understanding of diseases affecting the kidneys and may also lead to new therapeutic agents.

show abstract