Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer

Hadi, Marym Mohammad; Nesbitt, Heather; Masood, Hamzah; Sciscione, Fabiola; Patel, Sneh; Ramesh, Bala; Emberton, Mark; Callan, John F.; MacRobert, Alexander J.; McHale, Anthony P.; Nomikou, Nikolitsa

doi:10.1016/j.jconrel.2020.11.040

Cited by 39 publications

(33 citation statements)

References 28 publications

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“…It is well established that the high metabolism and insufficient oxygen supply of tumor cells are the major mechanisms for the formation of the acidic extracellular milieu of solid tumors . This acidic characteristic of the TME provides a promising tool for the design of pH-responsive nanocarriers, which are destabilized and specifically release the entrapped cargoes under the acidic TME while stabilized in the bloodstream.…”

Section: Resultsmentioning

confidence: 99%

Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Phung

Tran

Choi

et al. 2021

ACS Appl. Mater. Interfaces

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Cellular FLIP (cFLIP) is a crucial player of apoptosis-regulated pathways that is frequently overexpressed in solid cancers. To inhibit c-FLIP, preand post-transcriptionally, a multifunctional nanoparticle (NP) was created to deliver cFLIP-specific small interfering RNA (siRNA) into cancer cells. Specifically, Vorinostat (Vor)-loaded mesoporous silica nanoparticles (MSN) were conjugated with polyethylenimine-biotin (PB), followed by electrostatically binding with cFLIP siRNA (Vor/siR@MSN-PB). To stabilize and prolong the circulation time of nanoparticles, a bialdehyde-modified poly(ethylene glycol) (PEG) was cross-linked onto the polyethylenimine (PEI) backbone via the formation of the imine linkage (Schiff base

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Section: Resultsmentioning

confidence: 99%

Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Phung

Tran

Choi

et al. 2021

ACS Appl. Mater. Interfaces

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“…[95] Hadi et al investigated the potential of a novel stimulus-responsive nanoparticle formulation in the treatment of prostate cancer. [96] They prepared the formulation based on the self-assembly of poly(Lglutamic acid-L-tyrosine) (PGATyr) copolymer with 15. They tested the response of the formulation to a proteolytic enzyme cathepsin B secreted often in the solid tumor microenvironment and observed nanoparticle size reduction.…”

Section: To Cure Cancermentioning

confidence: 99%

“…Such kind of approach seems to be promising in the treatment of prostate cancer and other recalcitrant cancers. [96] Cao et al developed a novel formulation, a tablet-like TiO 2 /C nanocomposite with a metal-organic-framework (MOF)-derived carbon structure to apply it to facilitate SDT under hypoxic conditions of solid pancreatic tumors. [19] They divided Panc02 cells into six groups, including 1) control 2) US 3)TiO 2 /C 4) TiO 2 / C + US (TiO 2 /C + US × 1) 5) TiO 2 /C + US twice (TiO 2 /C + US × 2) 6) TiO 2 /C + US three times (TiO 2 /C + US × 3).…”

Section: To Cure Cancermentioning

confidence: 99%

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Wysocki

Czarczyńska-Goślińska

Ziental

et al. 2022

ChemMedChem

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Photodynamic and sonodynamic therapy are therapies having great potential in the treatment of bacterial infections and cancer. Their background is associated with photo-and sonosensitizers -substances that can be excited when exposed to light or ultrasound. These sensitizers belong to a various groups of compound, including porphyrins, porphyrazines, and phthalocyanines. Releasing the energy when returning to the ground state can occur in the manner of transferring it to oxygen molecules, leading to reactive oxygen species able to disrupt membranes of bacterial and cancer cells, leaving the organism's cells unaffected. In recent years, the number of reports on numerous sensitizers being effective has been constantly growing. Therefore, the development of this field may prove beneficial for dealing with cancer and microbes. This review describes the development of photodynamic and sonodynamic therapy, as well as their combination, with emphasis on sonodynamic therapy and its potential in the treatment of cancer and bacterial infections.

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“…SDT is likely to become the first-line treatment for prostate cancer patients, especially those who do not meet the eligibility criteria for standard local ablation methods, such as HIFU. Since SDT does not require the insertion of electrodes or probes inside or near the affected area, the treatment can be performed with minimal effects on the tissue [ 44 ].…”

Section: Cancer-specific Treatmentsmentioning

confidence: 99%

Current Landscape of Sonodynamic Therapy for Treating Cancer

Yamaguchi

Kitahara

Kusuda

et al. 2021

Cancers

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Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug’s ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.

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Investigating the performance of a novel pH and cathepsin B sensitive, stimulus-responsive nanoparticle for optimised sonodynamic therapy in prostate cancer

Cited by 39 publications

References 28 publications

Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

Current Landscape of Sonodynamic Therapy for Treating Cancer

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