Investigating the potential link between seroprevalence of Toxoplasma IgG and both types of diabetes mellitus in Benha city, Egypt

Abstract

Despite innate acute inflammatory responses and antigen-specific adaptive immunity, T. gondii can infect and multiply in any nucleated host cells, resulting in the generation of different inflammatory markers that promote a chronic inflammatory state [7] . Numerous studies have shown a significant correlation between chronic T. gondii infection and various neurological conditions and malignancies. Additional autoimmune disorders include thyroid disease, systemic sclerosis, rheumatoid arthritis, and inflammatory bowel syndrome [8][9][10][11][12] . Symptomatic toxoplasmosis is less common in immunocompetent individuals, but this does not prevent development of tissue cysts in asymptomatic infections. Toxoplasmosis in humans can be identified by isolation, serology, histology, molecular detection,

Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017–2018

“…Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetic, environmental, and immunological factors determine the selective degradation of insulin-secreting beta cells in the pancreas. [ 1 ] Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases that occur when a person has high blood sugar levels and the pancreas is unable to produce enough insulin, or the cells respond to the insulin produced. [ 1 ] With the decline in physical activity and changes in diet and lifestyle, its prevalence has increased dramatically.…”

“…[ 1 ] Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases that occur when a person has high blood sugar levels and the pancreas is unable to produce enough insulin, or the cells respond to the insulin produced. [ 1 ] With the decline in physical activity and changes in diet and lifestyle, its prevalence has increased dramatically. [ 2 ] This epidemic has created major health problems for human societies.…”

“…Diabetes is the fifth leading cause of death in Western societies and the ninth leading cause of death in Iranian men. [ 1 ] This number indicates that there are 415 million people with diabetes in the world in 2015, and this number will increase to 642 million in 2040. [ 1 ]…”

“…[ 1 ] This number indicates that there are 415 million people with diabetes in the world in 2015, and this number will increase to 642 million in 2040. [ 1 ]…”

“…A wide range of hosts, including humans, domestic mammals, and birds, may be infected. [ 1 ] Tissue cysts formed during infections are controlled by the humoral immune system and cellular immunity. [ 1 ] TH1 lymphocytes and macrophages are constantly stimulated by parasitic antigens, in which gamma interferon plays a key role.…”