Investigating the relationship between job stress, workload and oxidative stress in nurses

Biganeh, Jamal; Ashtarinezhad, Azadeh; Behzadipour, Davood; Khanjani, Narges; Nik, Atefeh Tavakoli; Hosseinabadi, Majid Bagheri

doi:10.1080/10803548.2021.1877456

Cited by 18 publications

(18 citation statements)

References 47 publications

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“…Decreasing the MDA level in mice with autoimmune encephalomyelitis has been shown to improve over motor functions 30 . The MDA level was found to be higher in nurses with high workload and stress than the control group 31 . In our study, a significant decrease was achieved in MDA levels after keto/amino acid supplementation.…”

Section: Discussionsupporting

confidence: 42%

Can keto/amino acids reduce oxidative stress in peritoneal dialysis patients with hypoalbuminemia?

Çankaya

Bilen

Uyanik

et al. 2021

Seminars in Dialysis

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Introduction There is no consensus on an ideal marker of oxidative stress (OS). Disruption of the balance between free radical and antioxidant activity production by increasing oxidative markers results in OS. In this study, we aimed to investigate how OS, which increases mortality and morbidity due to various reasons, is affected by keto/amino therapy in patients with hypoalbuminemia undergoing peritoneal dialysis. Materials and Method Twenty patients who underwent peritoneal dialysis were included in the study. Before starting keto/amino acid therapy, primary kidney diseases were determined, body mass indexes, serum total protein, albumin, C‐reactive protein, ferritin, calcium, phosphorus, parathyroid hormone, paraoxonase‐1 (PON‐1), sialic acid levels, arylesterase (ARE) activities, and malondialdehyde (MDA) levels were measured, and Kt/V values were calculated. Keto/amino acid treatment was initiated for those with an albumin level of <3.5 g/dL. The same parameters of the patients, followed up for 3 months, were checked again at the end of the third month. Results Paraoxonase‐1 and ARE activities, which are antioxidant enzyme activities, were found to be statistically significantly increased compared to the initial period (59 ± 59, 135 ± 69, 15.8 ± 19.7, and 44.7 ± 16.4, respectively; p < 0.00). MDA and sialic acid levels were significantly lower than the initial values (109 ± 99, 23 ± 9, 2.26 ± 0.44, and 2.04 ± 0.39, respectively; p < 0.01). Conclusion In our study, after the initiation of keto/amino acid treatment, PON‐1, which is a significant antioxidant marker, and ARE plasma activities increased and tissue destruction product MDA and sialic acid significantly decreased. In the light of all these data, we think that this treatment can reduce OS, improve hypoalbuminemia, which causes both mortality and morbidity in patients, improve survival in PD patients, and may be an antioxidant treatment in suitable patients.

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Section: Discussionsupporting

confidence: 42%

Can keto/amino acids reduce oxidative stress in peritoneal dialysis patients with hypoalbuminemia?

Çankaya

Bilen

Uyanik

et al. 2021

Seminars in Dialysis

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“…Studies of the ERI model occupational stress found a significant positive correlation between over-commitment and E/R ratio and MDA levels [29,30]. Another survey of occupational stress in nurses found that the occupational stress level was negatively correlated with TAC and SOD [31]. Some studies have found a positive correlation between occupational stress and SOD [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Analysis of occupational stress and its correlation with oxidative-antioxidant levels among employees of a power grid enterprise in Guangdong

et al. 2022

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Background Occupational stress and its health effects on occupational populations have attracted extensive attention from researchers in public health. The stressors faced by employees of power grid enterprises are increasing progressively, which is easy to cause occupational stress. The balance of the body’s oxidative-antioxidant levels plays an essential role in maintaining the body’s health status. This study aims to explore occupational stress and its correlation with oxidative-antioxidant levels in employees of a power grid enterprise. Methods A cluster random sampling method was used to investigate the basic information of 528 employees in a power grid enterprise and investigate the two occupational stress models of employees by using the Job Content Questionnaire based on the job demand-control-support (JDC) model, and the Effort-Reward Imbalance Questionnaire based on the effort-reward imbalance (ERI) model, respectively. Peripheral blood samples were collected from the employees to measure the levels of malondialdehyde (MDA), total antioxidant capacity (TAC), and superoxide dismutase (SOD). The correlation between different models of occupational stress level and the body’s oxidation-antioxidation level was further explored. Results The detection rate of high JDC model occupational stress was 50.6% and the detection rate of high ERI model occupational stress was 50.9%. The JDC model occupational stress was significantly associated with high-temperature and high-altitude operation, visual display terminal operation, monthly income, and exercise (all P < 0.05). The ERI model occupational stress was significantly associated with visual display terminal operation (all P < 0.05). The results of the generalized additive model showed that SOD levels had a non-linear relationship with the D/C ratio as well as the E/R ratio. With the D/C ratio close to 1, SOD levels raised rapidly. When the E/R ratio exceeded 1, the SOD level raised rapidly (all P<0.05) . TAC levels were negatively associated with the E/R ratio (P < 0.05). Conclusion The detection rates of occupational stress in both models among employees in a power grid enterprise are higher. ERI model occupational stress was associated with body TAC and SOD levels, and JDC model occupational stress was associated with body SOD levels.

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“…showed in their study that occupational stress among nurses causes a significant increase in MDA levels. [ 26 ]…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of educational intervention on reducing oxidative stress caused by occupational stress in nurses

Sahlabadi

Panahi

Pirposhteh

et al. 2022

Journal of Education and Health Promotion

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BACKGROUND: Nursing is one of the most stressful occupations. Educational intervention regarding stress management can play an important role in reducing occupational stress among nurses The present study aimed to determine the effectiveness of educational intervention on reducing oxidative stress caused by occupational stress in nurses: A health promotion approach in a hospital in western Iran. MATERIALS AND METHODS: The present interventional study was performed in 2019 among 92 nurses working at the Kosar Hospital located in the city of Sanandaj in the country of Iran. Occupational stress was evaluated using the Osipow Occupational Stress Questionnaire. Oxidative stress was measured by taking blood samples and measuring the enzymatic activity of superoxide dismutase (SOD), malondialdehyde, and catalase (CAT) using SOD, malondialdehyde (MDA), and CAT kits. Educational intervention was carried out in the second stage. Three months after the intervention, data were taken again. RESULTS: The results of the present study indicated that there was a significant difference in occupational stress between before and after the educational intervention ( P < 0.05). A significant reduction in MDA ( P = 0.038) and SOD ( P = 0.048) was observed after educational intervention, but this was not the case for CAT ( P = 0.592). There was no significant correlation between occupational stress with oxidative stress parameters before and after the educational intervention ( P < 0.05). No significant difference in occupational stress was observed between men and women. Among the oxidative stress parameters under evaluation, MDA was higher among men compared to women and this was statistically significant. CONCLUSIONS: Educational intervention regarding occupational stress is effective in reducing oxidative stress among nurses. The group meetings teach stress management to the participants and enable them to better manage their stress by utilizing their own capabilities. Thus, attention to this issue is vital in maintaining the mental and physical health of nurses and, in turn, improves the quality of care rendered.

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Investigating the relationship between job stress, workload and oxidative stress in nurses

Cited by 18 publications

References 47 publications

Can keto/amino acids reduce oxidative stress in peritoneal dialysis patients with hypoalbuminemia?

Can keto/amino acids reduce oxidative stress in peritoneal dialysis patients with hypoalbuminemia?

Analysis of occupational stress and its correlation with oxidative-antioxidant levels among employees of a power grid enterprise in Guangdong

Effectiveness of educational intervention on reducing oxidative stress caused by occupational stress in nurses

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