Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Suzuki, Keisuke; Suzuki, Shigeaki; Shiina, Tomohiko; Okamura, Madoka; Haruyama, Yasuo; Tatsumoto, Muneto; Hirata, Koichi

doi:10.1186/s10194-021-01294-8

Cited by 15 publications

(18 citation statements)

References 20 publications

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“…The prevalence of CS found in our study is in line with previous findings about chronic migraine or low back pain. 44 , 46 , 51 However, it is much higher than that in a Japanese study on chronic musculoskeletal pain (less than 30%). 31 The discrepancies could be explained by the different clinical characteristics of the sample population in the present study.…”

Section: Discussionmentioning

confidence: 68%

“…The presence of CS has previously been evidenced in persistent pain disorders including chronic headache, musculoskeletal pain, as well as neuropathic pain. [44][45][46][47][48][49] CS can be measured by quantitative methods for heat and cold pain thresholds as well as pressure pain thresholds. 12,27,50 Given the time-and labor-consuming nature of QST measures, a CSI scale has been developed to screen CS in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Part B (without scoring) aims to find out if the participants have been diagnosed with a list of disorders including CSSs and anxiety and depression. In addition, the clinically relevant severity levels for CSI were established, which included 5 categories, namely subclinical CS (0-29), mild (30)(31)(32)(33)(34)(35)(36)(37)(38)(39), moderate (40)(41)(42)(43)(44)(45)(46)(47)(48)(49), severe (50)(51)(52)(53)(54)(55)(56)(57)(58)(59), and extreme CS (≥60). 29 The psychometric properties of the CSI in English, as well as other languages, have been evaluated and shown to be a solid instrument to screen CS symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes

Feng¹,

Hu²,

Lu³

et al. 2022

JPR

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Background: Central sensitization (CS) is frequently reported in chronic pain, and the central sensitization inventory (CSI) is popularly used to assess CS. However, a validated Chinese CSI is lacking and its predictive ability for the comorbidity of central sensitivity syndromes (CSSs) remains unclear. Hence, this study aimed to generate the Chinese CSI (CSI-C) with cultural adaptation and examine its psychometric properties. Methods: The CSI-C was formulated through forward and backward translation, panel review and piloting and then validated among patients with chronic pain (n = 235). Its internal consistency, test-retest reliability, and concurrent validity were measured. An exploratory factor analysis (EFA) was performed for the construct validity. Receiver operating characteristic (ROC) analysis was employed to determine the discriminative ability in the presence of comorbidity of CSSs. Results: About 70% of the participants in the study experienced at least mild CS symptoms. CSI-C demonstrates a high internal consistency (Cronbach's alpha = 0.896) and excellent test-retest reliability (ICC = 0.932). CSI-C scoring was significantly correlated with pain intensity (r = 0.188), EQ-5D index (r = −0.375), anxiety (r=0.525), and depression (r = 0.467). The EFA generated a 5-factor model, including physical symptoms, emotional distress, hypersensitivity syndromes and so on. An CSI cutoff of 42 had a sensitivity of 71.4% and a specificity of 70% for identifying chronic pain patients with ≥2 CSSs. Conclusion:The CS manifestations are prevalent in those with persistent pain. CSI-C is a reliable and valid instrument for measuring CS. A CSI score ≥42 may predict the comorbidity of 2 or above CSSs in patients with chronic pain.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes

Feng¹,

Hu²,

Lu³

et al. 2022

JPR

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“…In a cross-sectional study, photophobia, phonophobia and osmophobia were observed in 75.4%, 76.5% and 55.1% of patients with migraine, respectively; these hypersensitivities exhibited substantial overlap, as the proportions of patients with 2 and 3 coexisting sensory hypersensitivities were 33.2% and 41.7%. 57 In the same study, the migraine Disability Assessment score was found to be higher in patients with 3 sensory hypersensitivities than in those with 0–2 sensory hypersensitivities. These results, which illustrate the burden of multiple hypersensitivity symptoms, may support the contribution of CS to migraine.…”

Section: Methodsmentioning

confidence: 82%

Central Sensitization in Migraine: A Narrative Review

Suzuki¹,

Suzuki²,

Shiina³

et al. 2022

JPR

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Central sensitization (CS) is an increase in the responsiveness of nociceptive neurons in the central nervous system to their normal afferent input. As a result, even minor irritation can induce severe pain, leading to the chronicity and severity of various diseases, such as neurological disorders. CS is associated with migraine, which is a major neurological disorder that inflicts a high disability in daily life. Specifically, CS is thought to be involved in the pathogenesis of cutaneous allodynia as well as chronification of migraine. In this article, we reviewed the association between CS and migraine, including pathophysiological aspects and evidence from clinical studies. We suggest that appropriate screening and management of CS in migraine could further improve the quality of life of migraine patients.

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“…Another study however, did not find an association between disease duration and interictal olfactory hypersensitivity [8]. Data on subjective sensory hypersensitivity in 187 patients with migraine showed not only a common overlap of subjective sensory hypersensitivities to light, noise and smell but also a clear relation between sensory hypersensitivities and migraine disability [22]. Pre/ictal osmophobia has so far not been investigated in this context.…”

Section: Discussionmentioning

confidence: 95%

Interictal osmophobia is associated with longer migraine disease duration

et al. 2022

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Background Sensitization to sensory stimuli is an essential feature of migraine attacks. The relationship between the clinical course of migraine and increased sensitivity to olfactory stimuli has been little studied so far. Methods We analyzed the frequency and quality of osmophobia depending on the phase of migraine in patients with episodic and chronic migraine treated in an tertiary headache center with regard to gender, age, medical history and migraine disability assessment score (MIDAS). Standardized diagnostic questions were used for the assessment of osmophobia. Results In our cross-sectional investigation (n = 113), 38.1% of the patients showed an increased preictal hypersensitivity to odors, whereas 61.9% described ictal and 31.9% interictal hypersensitivity to odors, odor-triggered migraine was described in 30.1%. Median migraine disease duration has been statistically significantly longer in patients who suffered from interictal hypersensitivity to odors (28.5 years vs. 20 years; p = 0.012). There was a significant correlation between interictal hypersensitivity and higher age (54.50 vs. 45; p = 0.015). Patients with higher migraine disability in MIDAS experienced more frequently preictal and interictal olfactory sensitization and odor triggered migraine attacks. Conclusions In patients with longer migraine disease duration and higher migraine-related impairment, osmophobia was more frequently observed. These results might support the hypothesis of increasing sensitization with increasing burden of migraine.

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Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Cited by 15 publications

References 20 publications

Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes

Cultural Validation of the Chinese Central Sensitization Inventory in Patients with Chronic Pain and its Predictive Ability of Comorbid Central Sensitivity Syndromes

Central Sensitization in Migraine: A Narrative Review

Interictal osmophobia is associated with longer migraine disease duration

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