Investigating the role of BDNF and CCK system genes in suicidality in a familial bipolar cohort

Risk factors for suicide in bipolar disorder: A systematic review

“…Table 1 provides an overview of all studies included in the final sample and of all data elements used during the data analysis process. Study designs included one case report (Kerner et al, 2013), seven transversal studies (Goldstein et al, 2012;Kheirabadi et al, 2012;Undurraga et al, 2012;De Abreu et al, 2012;Algorta et al, 2011;Evans et al, 2012;Gomes et al, 2010), nineteen cohort studies (Parmentier et al, 2012;Huber et al, 2014;Ruengorn et al, 2012;Etain et al, 2013;Cassidy, 2011;Baldessarini et al, 2012;Bellivier et al, 2011;Sears et al, 2013;Jiménez et al, 2013;Leon et al, 2012;Finseth et al, 2012;Oquendo et al, 2010;Kenneson et al, 2013;Gilbert et al, 2011;Shabani et al, 2013;Acosta et al, 2012;Song et al, 2012;Suttajit et al, 2013), and fifteen case-control studies (Eroglu et al, 2013;Antypa et al, 2013;Ryu et al, 2010;Manchia et al, 2013;Neves et al, 2010;Magno et al, 2011;Yoon et al, 2011;Arias et al, 2013;Clements et al, 2013;Kamali et al, 2012;de Moraes et al, 2013;Azorin et al, 2013;…”

“…Risk factors associated with sociodemographic components (seven studies) (Huber et al, 2014;De Abreu et al, 2012;Ruengorn et al, 2012;Algorta et al, 2011;Cassidy, 2011;Antypa et al, 2013;Ryu et al, 2010); Risk factors associated with genetic components (six studies) (Manchia et al, 2013;Sears et al, 2013;Neves et al, 2010;Magno et al, 2011;Jiménez et al, 2013;Kerner et al, 2013); Risk factors associated with Medicines and Drugs in general that interfere with bipolar disorder (eight studies) (Bellivier et al, 2011;Yoon et al, 2011;Leon et al, 2012;Arias et al, 2013;Clements et al, 2013;Finseth et al, 2012;Oquendo et al, 2010;Kenneson et al, 2013); Risk factors associated with Biological components (three studies) (Kamali et al, 2012;Evans et al, 2012;Gomes et al, 2010); Risk factors associated with Psychological causes (seven studies) (Parmentier et al, 2012;Shabani et al, 2013;Acosta et al, 2012;Song et al, 2012;Suttajit et al, 2013;Stewart et al, 2009); and Risk factors associated with components of Religious and Spiritual (three studies) components (Azorin et al, 2013;Dervic et al, 2011;. Among the 42 studies, 8 discussed about "suicide risk factors in Bipolar Affective disorder" -more broadly (Goldstein et al, 2012;Eroglu et al, 2013;Kheirabadi et al, 2012;Undurraga et al, 2012;…”

“…Post-mortem studies have shown that the expression of BDNF (Gene ID 627 in 11p13) is significantly reduced in individuals that have committed suicide, regardless of psychiatric diagnosis (Sears et al, 2013;Dwivedi et al, 2003;Karege et al, 2005). Moreover, an association between BDNF (Gene ID 627 in 11p13) gene and violent Suicide Attempt (SA) has been also detected in a sample of this patients (Neves et al, 2011;Jiménez et al, 2013).…”

“…Globally, approximately one million individuals commit suicide each year (WHO, 2011;Sears et al, 2013). Suicidal behavior is a matter of major concern in the management of BD patients for many reasons.…”

The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

“…Although non-genetic factors [e.g., exposure to family violence or imitation (24)] may play a role in this increased risk, studies on twins have estimated that 30%-50% of variance could be explained by genetic factors (25,26). Furthermore, evidence suggests that part of the heritability of suicidal behavior is independent of the transmission of mental disorders (27).…”