Investigating the role of the right inferior frontal gyrus in control perception: A double-blind cross-over study using ultrasonic neuromodulation

Forster, André; Rodrigues, Johannes; Ziebell, Philipp; Sanguinetti, Joseph L.; Allen, John J. B.; Hewig, Johannes

doi:10.1016/j.neuropsychologia.2023.108589

Cited by 8 publications

(3 citation statements)

References 72 publications

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“…Sanguinetti et al (2020) [46] reported that tFUS applied to the right inferior frontal gyrus (IFG) enhanced mood states and reduced functional connectivity in resting-state networks, as revealed by using rs-fMRI. In psychological investigations by Forster and colleagues (2023a,b) [47,48], tFUS administration to the right IFG modulated the emergence of 'learned helplessness' and midline theta EEG activities [48], and altered the processing of 'stimulus probability' and midfrontal theta EEG, without affecting 'control perception' [47]. Another study by the same group, conducted by Ziebell et al (2023) [49], demonstrated that tFUS to the right prefrontal cortex (PFC) decreased midfrontal theta EEG activity, accompanied by increased 'approach behavior' while 'withdrawal behavior' decreased, during a virtual T-maze task.…”

Section: Frontal Cortexmentioning

confidence: 99%

“…Single-element, focused (Neurotrek U+) 500 kHz Sanguinetti JL et al 2020 [46] EEG site F8 Reznik SJ et al 2020 [73] EEG site F8 Forster A et al 2023a [48] EEG site F8 Forster A et al 2023b [47] EEG site F8 Ziebell P et al 2023 [49] EEG site F8 4 List of tFUS/TUS transducers grouped by manufacturer, transducer type, and fundamental frequency (FF) used in the reviewed human studies, along with the targeting methods utilized reflections. Recent technological advances even allow for semi-real/real-time acoustic simulation, previously challenging due to high computational load.…”

Section: Strokementioning

confidence: 99%

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A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

Lee,

Park,

Lee

et al. 2024

Biomed. Eng. Lett.

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Transcranial ultrasonic neuromodulation is a rapidly burgeoning field where low-intensity transcranial focused ultrasound (tFUS), with exquisite spatial resolution and deep tissue penetration, is used to non-invasively activate or suppress neural activity in specific brain regions. Over the past decade, there has been a rapid increase of tFUS neuromodulation studies in healthy humans and subjects with central nervous system (CNS) disease conditions, including a recent surge of clinical investigations in patients. This narrative review summarized the findings of human neuromodulation studies using either tFUS or unfocused transcranial ultrasound (TUS) reported from 2013 to 2023. The studies were categorized into two separate sections: healthy human research and clinical studies. A total of 42 healthy human investigations were reviewed as grouped by targeted brain regions, including various cortical, subcortical, and deep brain areas including the thalamus. For clinical research, a total of 22 articles were reviewed for each studied CNS disease condition, including chronic pain, disorder of consciousness, Alzheimer's disease, Parkinson's disease, depression, schizophrenia, anxiety disorders, substance use disorder, drug-resistant epilepsy, and stroke. Detailed information on subjects/cohorts, target brain regions, sonication parameters, outcome readouts, and stimulatory efficacies were tabulated for each study. In later sections, considerations for planning tFUS neuromodulation in humans were also concisely discussed. With an excellent safety profile to date, the rapid growth of human tFUS research underscores the increasing interest and recognition of its significant potential in the field of non-invasive brain stimulation (NIBS), offering theranostic potential for neurological and psychiatric disease conditions and neuroscientific tools for functional brain mapping.

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Section: Frontal Cortexmentioning

confidence: 99%

Section: Strokementioning

confidence: 99%

A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

Lee,

Park,

Lee

et al. 2024

Biomed. Eng. Lett.

View full text Add to dashboard Cite

show abstract

“…For instance, increases in intensity (ISPPA, Box 1) and duty cycle can tip the balance from suppression to activation in the modelled populations of excitatory and inhibitory neurons (Plaksin et al, 2016). Several reviews have now conducted similar case-by-case or ad-hoc comparisons of TUS parameters with the NICE model predictions, with mixed support for or against the NICE model (Ai et al, 2018;Dell'Italia et al, 2022;Forster et al, 2023b;Zhang et al, 2023). In Box 3, we collate a set of net enhancement versus suppression hypotheses linked to TUS parameters that may be able to bias the directionality of effects.…”

Section: Directionality Of Tus Neuromodulationmentioning

confidence: 99%

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource

Caffaratti,

Slater,

Shaheen

et al. 2024

Preprint

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Low-intensity Transcranial Ultrasound Stimulation (TUS) is a promising non-invasive technique for deep-brain stimulation and focal neuromodulation. Research with animal models and computational modelling has raised the possibility that TUS can be biased towards enhancing or suppressing neural function. Here, we first conduct a systematic review of human TUS studies for perturbing neural function and alleviating brain disorders. We then collate a set of hypotheses on the directionality of TUS effects and conduct an initial meta-analysis on the human TUS study reported outcomes to date (n =32 studies, 37 experiments). We find that parameters such as the duty cycle show some predictability regarding whether the targeted area’s function is likely to be enhanced or suppressed. Given that human TUS sample sizes are exponentially increasing, we recognize that results can stabilize or change as further studies are reported. Therefore, we conclude by establishing an Iowa-Newcastle (inTUS) resource for the systematic reporting of TUS parameters and outcomes to support further hypothesis testing for greater precision in brain stimulation and neuromodulation with TUS.HighlightsSystematic review of human TUS studies for enhancing or suppressing neural functionCollated set of hypotheses on using TUS to bias towards enhancement or suppressionMeta-analysis results identify parameters that may bias the directionality of effectsTUS resource established for systematic reporting of TUS parameters and outcomes

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Inhibition of midfrontal theta with transcranial ultrasound explains greater approach versus withdrawal behavior in humans

Ziebell,

Rodrigues,

Forster

et al. 2023

Brain Stimulation

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Investigating the role of the right inferior frontal gyrus in control perception: A double-blind cross-over study using ultrasonic neuromodulation

Cited by 8 publications

References 72 publications

A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound

Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community Resource

Inhibition of midfrontal theta with transcranial ultrasound explains greater approach versus withdrawal behavior in humans

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