Investigating young adults with chronic diarrhoea in primary care

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“…It may be argued what 'clinically significant' represents; and indeed, this is somewhat subjective, but we would suggest that this represents the subsets of patients who either have evidence of malabsorption or objective markers of infiammation (e.g. anaemia, raised CRP and/or platelets, iron deficiency, hypoalbuminaemia, hypokalaemia and weight loss), 5 or who have frequent (greater than four times/day) or nocturnal diarrhoea. Indeed, this represents only a small subset of patients.…”