Investigation and comparison of resin materials in transparent DLP-printing for application in cell culture and organs-on-a-chip

Abstract

Transparent, cytocompatible and high resolution 3D-DLP-printing offers new opportunities in cell culture and organs-on-a-chip.

Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

“…In this context, organ-on-a-chip represents an advanced in vitro platform mimicking the characteristics of body tissues and organs. These devices are built using a reductionist approach since they aim to replicate the main features of the specified organ by using the appropriate microchannel architecture with specific cell types. − Organ-on-a-chip systems offer a powerful platform to evaluate NPs’ toxicity on specific tissues. Some examples of their applications will be discussed in the following sections.…”

Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications

“…Moreover, SLA/DLP printed devices can be highly transparent with appropriate printing set ups and post-processing techniques, making them more compatible with imaging-based measurements often used for microfluidic devices. [39][40][41] In all, these benefits position SLA/DLP as the most promising 3D printing modality to further develop microfluidic devices specifically for cell and tissue culture applications.…”

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

“…However, solvent extraction and UV exposure post-treatments are required to reduce cytotoxicity. 63 The potential of 3D printing as an OoC microfabrication technique is the possibility of fabricating monolithic microfluidic culturing devices employing materials with very different properties and functionalities. Often OoC devices require materials with different properties: transparency, conductivity, porosity, or flexibility.…”