Investigation and current management of recurrent IVF treatment failure in the UK

Tan, Bee K.; Vandekerckhove, Patrick; Kennedy, Rebekah; Keay, Stephen D.

doi:10.1111/j.1471-0528.2005.00523.x

Cited by 136 publications

(79 citation statements)

References 74 publications

(74 reference statements)

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“…RIF may simply be defined as two or more continuous implantation failures (2); however, researchers now prefer to define RIF as the failure to maintain a clinical pregnancy following three cycles of ET (3,4). Several causes of RIF have been reported, including embryo, uterine and immunological factors, as well as thrombophilic conditions, however, the genetic mechanisms underlying RIF remain unclear (1).…”

Section: Introductionmentioning

confidence: 99%

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

et al. 2017

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Abstract. The objective of the present study was to investigate the association between recurrent implantation failure (RIF) and vascular endothelial growth factor (VEGF) gene polymorphisms that are associated with various female infertility disorders. A total of 116 women diagnosed with RIF and 218 control subjects were genotyped for the VEGF -2578C>A, -1154G>A, -634C>G and 936C>T polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism assay. The VEGF -2578AA genotype was associated with an increased prevalence (≥4) of RIF [adjusted odds ratio (AOR)=2.77; 95% confidence interval (CI)=1.10-7.02; P=0.031], whereas the VEGF -634CG+GG genotype was associated with an increased incidence of total RIF (AOR=2.03; 95% CI=1.02-4.05; P=0.044) and ≥4 RIF (AOR=3.16; 95% CI=1.19-8.37; P=0.021). The results of the haplotype analysis indicated that -2578A/-1154A/-634G/936C (AOR=1.76; 95% CI=1.03-3.00; P=0.040 for total RIF and AOR=2.11; 95% CI=1.12-3.97; P=0.021 for ≥4 RIF) was associated with the occurrence of RIF. In addition, it was revealed that there was a significant difference in serum prolactin level associated with the VEGF -634C>G polymorphism (P=0.013). Therefore the findings of the present study indicate that the VEGF -2578AA genotype, -634G allele and -2578A/-1154A/-634G/936C haplotype may be genetic markers for susceptibility to RIF. However, further studies on VEGF promoter polymorphisms that include an independent randomized-controlled population are required to confirm these results.

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Section: Introductionmentioning

confidence: 99%

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

et al. 2017

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“…Forty women with a history of RIF after an ICSI-ET programme (defined in this study as a failure to achieve a pregnancy following 2 to 6 IVF cycles, in which more than 10 high-grade embryos were transferred to the uterus [39]. The control group comprised 131 women with at least one live birth after the transfer of fewer than 10 embryos.…”

Section: Patientsmentioning

confidence: 99%

The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI

Boudjenah

Molina-Gomès

Wainer

et al. 2012

J Assist Reprod Genet

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Purpose Successful embryo implantation depends on trophoblast proliferation, migration and, lastly, invasion of the endometrium (to anchor the trophoblast to the uterus). This invasion is mediated by locally produced soluble factors. Of these, vascular endothelial growth factor (VEGF) is the best characterized regulator of angiogenesis. Here, we investigate the association between the VEGF+405 C/G genotype and the recurrence of embryo implantation failure in women undergoing in vitro fertilization (IVF) program with intracytoplasmic sperm injection (ICSI). Methods Forty women with recurrent implantation failure defined by absence of pregnancy after transfer of more than 10 embryos and 131 women control, with at least one live birth after the transfer of fewer than 10 embryos were included. Genomic DNA was analysed with an allele-specific polymerase chain reaction and a Chi-2 test was used to compare the respective VEGF+405 C/G genotype frequencies in cases and controls. Results The frequency of the VEGF +405C/C genotype was higher in women with recurrent implantation failure after ICSI-embryo transfer than in controls (17.5 % and 5.3 %, respectively, p00.01). Conclusion The VEGF +405 G/C polymorphism may influence embryo implantation and VEGF+405 C/C genotype may predispose to recurrent implantation failure after ICSI-ET.

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“…A few years ago a new term -"repeated implantation failure" -was introduced (Margalioth et al, 2006;Tan et al, 2005). Recent years have shown that, despite the selection of obviously normal embryos for the transfer, only 20% of human embryos transferred in IVF cycles have been implanted in the uterus (International Committee for Monitoring Assisted Reproductive Technology (ICMART), 2002; Nyboe Andersen et al, 2009).…”

Section: Diminished Endometrial Receptivitymentioning

confidence: 99%

“…Margalioth et al (2006) concluded that detailed examination should be done after 3 unsuccessful IVF cycles. Thus, the main causes are the factors which diminish endometrial receptivity: anatomical defects in the uterus, chronic endometritis, non-correspondence between the endometrial thickness and the day of embryo transfer, combined gynecologic pathology (adenomyosis, uterine fibroid), somatic diseases (including autoimmune diseases), and thrombophilias (Margalioth et al, 2006;Tan et al, 2005).…”

Section: Diminished Endometrial Receptivitymentioning

confidence: 99%

The Means of Progress in Improving the Results of in vitro Fertilization Based on the Identification and Correction of the Pathology of Hemostasis

Момот¹,

Lydina²,

Цывкина³

et al. 2012

Enhancing Success of Assisted Reproduction

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Investigation and current management of recurrent IVF treatment failure in the UK

Abstract: Objective To determine current practice in the management of recurrent in vitro fertilisation (IVF) treatment failure in licensed UK infertility centres. Design National postal questionnaire study and literature review.

Cited by 136 publications

References 74 publications

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

Association between vascular endothelial growth factor promoter polymorphisms and the risk of recurrent implantation failure

The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI

The Means of Progress in Improving the Results of in vitro Fertilization Based on the Identification and Correction of the Pathology of Hemostasis

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