Investigation<i>heme oxygenase-1</i>polymorphism with the pathogenesis of preeclampsia

Lv, Xianping; Li, Xueying; Dai, Xiaoli; Liu, Mengchun; Wu, Cuijiao; Song, Weiqing; Wang, Jingli; Ren, Xiaoyan; Cai, Yan

doi:10.1080/10641963.2019.1601202

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…By comparing a EUR HDP cohort with a reference group (1 KG EUR), we found that a short GT expansion likely is protective against HDP as the L allele and the LL genotype are significantly enriched in the HDP cohort. However, for the A/T variant, no differences were observed at the allelic level in this EUR HDP cohort, consistent with the finding from a recent study on the A/T SNP (rs2071746) of HMOX , also revealing no significant differences in its polymorphisms between PE and control groups in a Chinese population [ 28 ]. However, the AA genotype is more enriched in our HDP cohort compared with the ancestral reference group.…”

Section: Discussionsupporting

confidence: 91%

HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy

et al. 2022

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Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme oxygenase-1 (HO-1) is encoded by HMOX1, which has genetic polymorphisms in its regulatory region that impact its expression and activity and have been associated with various diseases. However, studies of these genetic variants in HDP have been limited. The objective of this study was to examine HMOX1 as a potential genetic contributor of ancestral disparity seen in HDP. First, the 1000 Genomes Project (1 KG) phase 3 was utilized to compare the frequencies of alleles, genotypes, and estimated haplotypes of guanidine thymidine repeats (GTn; containing rs3074372) and A/T SNP (rs2071746) among females from five ancestral populations (Africa, the Americas, Europe, East Asia, and South Asia, N = 1271). Then, using genomic DNA from women with a history of HDP, we explored the possibility of HMOX1 variants predisposing women to HDP (N = 178) compared with an equivalent ancestral group from 1 KG (N = 263). Both HMOX1 variants were distributed differently across ancestries, with African women having a distinct distribution and an overall higher prevalence of the variants previously associated with lower HO-1 expression. The two HMOX1 variants display linkage disequilibrium in all but the African group, and within EUR cohort, LL and AA individuals have a higher prevalence in HDP. HMOX1 variants demonstrate ancestral differences that may contribute to racial disparity in HDP. Understanding maternal genetic contribution to HDP will help improve prediction and facilitate personalized approaches to care for HDP.

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Section: Discussionsupporting

confidence: 91%

HMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy

et al. 2022

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“…However, genetic studies have suggested some association with preeclampsia, including variations in MS-like tyrosine kinase 1 and vascular endothelial growth factor C 12 and a microsatellite variation in the heme-oxygenase 1promoter in a Finnish cohort 13 but not in a Chinese cohort. 14 Thus, based on the various types of evidence available from current research and the potential impact of health care infrastructure on diagnosis, management, and related complications of preeclampsia, we hypothesized that the etiology, severity, and consequences of preeclampsia may differ in a country-level comparison of China and Sweden.…”

Section: Introductionmentioning

confidence: 99%