Investigation into the in vitro release properties of β-carotene in emulsions stabilized by different emulsifiers

Hou, Zhanqun; Liu, Yuwei; Lei, Fei; Gao, Yanxiang

doi:10.1016/j.lwt.2014.07.045

Cited by 46 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Emulsion-based delivery systems can be produced using various emulsification processes and they have been widely used to protect bioactive compounds such as carotenoids from degradation, ameliorate its dispersion in an aqueous media, and increase its bioaccessibility [10][11][12][13][14][15][16]. However, in the last years, oil droplet reduction in the range of 20-500 nm [17] showed several advantages over conventional emulsions.…”

Section: Introductionmentioning

confidence: 99%

Improving the In Vitro Bioaccessibility of β-Carotene Using Pectin Added Nanoemulsions

Teixé-Roig

Oms‐Oliu

Ballesté-Muñoz

et al. 2020

Foods

View full text Add to dashboard Cite

The intestinal absorption of lipophilic compounds such as β-carotene has been reported to increase when they are incorporated in emulsion-based delivery systems. Moreover, the reduction of emulsions particle size and the addition of biopolymers in the systems seems to play an important role in the emulsion properties but also in their behavior under gastrointestinal conditions and the absorption of the encapsulated compound in the intestine. Hence, the present study aimed to evaluate the effect of pectin addition (0%, 1%, and 2%) on the physicochemical stability of oil-in-water nanoemulsions containing β-carotene during 35 days at 4 • C, the oil digestibility and the compound bioaccessibility. The results showed that nanoemulsions presented greater stability and lower β-carotene degradation over time in comparison with coarse emulsion, which was further reduced with the addition of pectin. Moreover, nanoemulsions presented a faster digestibility irrespective of the pectin concentration used and a higher β-carotene bioaccessibility as the pectin concentration increased, being the maximum of ≈36% in nanoemulsion with 2% of pectin. These results highlight the potential of adding pectin to β-carotene nanoemulsions to enhance their functionality by efficiently preventing the compound degradation and increasing the in vitro bioaccessibility.

show abstract

Section: Introductionmentioning

confidence: 99%

Improving the In Vitro Bioaccessibility of β-Carotene Using Pectin Added Nanoemulsions

Teixé-Roig

Oms‐Oliu

Ballesté-Muñoz

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…Nanosized carriers, such as oil drops, polymers, lipoproteins, liposomes and micelles allow one to prepare water dispersions of carotenoids with enhanced stability (Hou, Liu, Lei, & Gao, 2014;Toniazzo et al, 2014;Tan et al, 2014;Ascenso et al, 2013;Luxsuwong, Indranupakorn, & Wongtrakul, 2014;Donhowe & Kong, 2014;Acevedo et al, 2014;Bustos-Garza, Yanez-Fernandez, & Barragan-Huerta, 2013).…”

Section: Introductionmentioning

confidence: 99%

Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Polyakov

Kispert

2015

Carbohydrate Polymers

View full text Add to dashboard Cite

Since carotenoids are highly hydrophobic, air- and light-sensitive hydrocarbon compounds, developing methods for increasing their bioavailability and stability towards irradiation and reactive oxygen species is an important goal. Application of inclusion complexes of "host-guest" type with polysaccharides and oligosaccharides such as arabinogalactan, cyclodextrins and glycyrrhizin minimizes the disadvantages of carotenoids when these compounds are used in food processing (colors and antioxidant capacity) as well as for production of therapeutic formulations. Cyclodextrin complexes which have been used demonstrated enhanced storage stability but suffered from poor solubility. Polysaccharide and oligosaccharide based inclusion complexes play an important role in pharmacology by providing increased solubility and stability of lipophilic drugs. In addition they are used as drug delivery systems to increase absorption rate and bioavailability of the drugs. In this review we summarize the existing data on preparation methods, analysis, and chemical reactivity of carotenoids in inclusion complexes with cyclodextrin, arabinogalactan and glycyrrhizin. It was demonstrated that incorporation of carotenoids into the "host" macromolecule results in significant changes in their physical and chemical properties. In particular, polysaccharide complexes show enhanced photostability of carotenoids in water solutions. A significant decrease in the reactivity towards metal ions and reactive oxygen species in solution was also detected.

show abstract

“…WPI was then be hydrolyzed by trypsin at pH = 7 (Table 1; p < 0.05; Teo et al., 2016). Proteolyzed WPI thus led to breakdown of the oil‐in‐water structure of the nanoemulsion (Hou et al., 2014; Qiu et al., 2015; Xu, Yuan et al., 2013). The oil droplet was hydrolyzed after exposure to pancreatin.…”

Section: Resultsmentioning

confidence: 99%

“…Compared with many large molecule emulsifiers, WPI has its unique advantages. For example, whey protein (a) has proper conformational, electrostatic, and amphiphilic nature (Fan, Yi, Zhang, Wen, & Zhao, 2017); (b) has good ability in binding metal ions and scavenging free radicals via amino acids such as tyrosine and cysteine (Yi et al., 2016); and (c) can effective improve the bioaccessibility of beta‐carotene in emulsions (Hou, Liu, Lei, & Gao, 2014). …”

Section: Introductionmentioning

confidence: 99%

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils

Zhou

Wang

et al. 2018

Food Science & Nutrition

View full text Add to dashboard Cite

Beta‐carotene, the main dietary source of provitamin A, is required for maintaining optimum human health. The bioaccessibility of beta‐carotene can be greatly improved when ingested with fat. Therefore, the aim of the current study was to select proper oils (palm oil, coconut oil, fish oil, and corn oil) as a carrier to form stable nanoemulsion that can effectively enhance the bioaccessibility of beta‐carotene. The nanoemulsion was formulated with 90% (v/v) aqueous solution (2% whey protein isolate, WPI, w/v) and 10% (v/v) dispersed oil. The in vitro digestion experiment of nanoemulsions showed that the bioaccessibility of beta‐carotene was as followed in order: palm oil = corn oil > fish oil > coconut oil (p < 0.05). The particle size of the nanoemulsion (initial particle size = 168–185 nm) was below 200 nm during 42 days’ storage at 25°C. The retention rates of beta‐carotene in nanoemulsions were 69.36%, 63.81%, 49.58%, and 54.91% with palm oil, coconut oil, fish oil, and corn oil, respectively. However, the particle size of the nanoemulsion increased significantly in the accelerated experiment at 55°C (p < 0.05), in which the retention rates of beta‐carotene were 48.56%, 43.41%, 29.35%, and 33.60% with palm oil, coconut oil, fish oil, and corn oil, respectively. From above, we conclude that WPI‐stabilized beta‐carotene nanoemulsion with palm oil as the carrier is the most suitable system to increase bioaccessibility and stability of lipid‐soluble bioactive compounds such as beta‐carotene.

show abstract

Investigation into the in vitro release properties of β-carotene in emulsions stabilized by different emulsifiers

Cited by 46 publications

References 30 publications

Improving the In Vitro Bioaccessibility of β-Carotene Using Pectin Added Nanoemulsions

Improving the In Vitro Bioaccessibility of β-Carotene Using Pectin Added Nanoemulsions

Water soluble biocompatible vesicles based on polysaccharides and oligosaccharides inclusion complexes for carotenoid delivery

Stability and in vitro digestibility of beta‐carotene in nanoemulsions fabricated with different carrier oils

Contact Info

Product

Resources

About