Investigation of a novel chemically cross-linked fricke-Methylthymol blue-synthetic polymer gel dosimeter with glutaraldehyde cross-linker

Eyadeh, Molham M.; Rabaeh, Khalid A.; Hailat, Tariq F.; Al-Shorman, M.; Aldweri, Feras M.; Kanan, Haitham M.; Awad, Samer I.

doi:10.1016/j.radmeas.2018.09.013

Cited by 32 publications

(19 citation statements)

References 38 publications

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“…Another promising approach to the functionalization of the gel matrix was recently described by Lazzaroni et al [ 50 ]. Alternatives to the use of xylenol orange are also actively investigated [ 51 ] and among them methylthymol blue appears to be a promising option [ 52 ].…”

Section: Fricke Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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Section: Fricke Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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“…The presence of paramagnetic Fe 3+ alters the proton relaxation times of water and these changes can be measured by means of Nuclear Magnetic Resonance (NMR) relaxometry [12] and Magnetic Resonance Imaging (MRI) [10,13]. Furthermore, the spatial distribution of Fe 3+ can be used to produce a 3D dose map by optical imaging [14,15] if a suitable metallic ion indicator is added to the gel matrix [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…As per the literature, the mechanical and thermal attributes of the PVA-based polymeric architectures can be improved by crosslinking the polymer using irradiation or bi/multi-functional reactive group-containing chemical agents (e.g., glutaraldehyde (GTA)) [9,10]. Over the years, various GTA crosslinked PVA-based architectures (such as hydrogels, films, nanofibers, and nanoparticles) have been explored for drug delivery, tissue engineering, wound healing, and dosimetry applications [11][12][13][14][15][16][17][18][19][20]. Furthermore, owing to the tissue-mimicking properties, PVA-based matrices have acquired peculiar attention as soft tissue phantoms in biomedical research for the substitution of real tissues in vitro [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films

Qureshi

Sahoo

Mohanty³

et al. 2021

Gels

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In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a composition-dependent manner. As evident from the thermal analysis, COS content profoundly impacted the evaporation of water molecules from the composite films. Stress relaxation studies demonstrated that the blend films exhibited more mechanical stability as compared to the control film. The impedance profiles indicated the capacitive-dominant behavior of the prepared films. Ciprofloxacin HCl-loaded films showed excellent antimicrobial activity against Escherichia coli and Bacillus cereus. The prepared films were observed to be biocompatible. Hence, the prepared PVA/COS-based blend films may be explored for drug delivery applications.

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Investigation of a novel chemically cross-linked fricke-Methylthymol blue-synthetic polymer gel dosimeter with glutaraldehyde cross-linker

Cited by 32 publications

References 38 publications

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Effect of ionizing radiation on the colorimetric properties of PVA-GTA Xylenol Orange Fricke gel dosimeters

Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films

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