Investigation of a test system for the rapid differentiation of nuclear and cytoplasmic damage in eucaryotes

Ehrlich, W.; Mangir, M.; Lochmann, Ernst-Randolf; Nischt, Roswitha; Bradish, P.

doi:10.1016/0147-6513(85)90036-3

Cited by 7 publications

(2 citation statements)

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“…A significant time lag, in contrast, correlates well with damage to cytoplasmatic structures. 8 After treatment with both platinum compounds similar correlations can be seen not only in the course of cell growth and RNA synthesis but also in that of DNA, protein, ribosome synthesis and free ribosome content. In summarizing these findings, the effects of cisplatin and PtCl 4 follow the same pattern: inhibition but no significant time lag.…”

Section: Discussionmentioning

confidence: 88%

“…The results were evaluated on the basis of a test system for rapid differentiation of nuclear and cytoplasmatic damage developed by Ehrlich, Mangir and Lochmann, which is founded on qualitative changes in growth curves and in RNA synthesis rates. 8 Furthermore, the effects on DNA, protein, ribosome synthesis and ribosome content were investigated.…”

Section: Introductionmentioning

confidence: 99%

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The effect of cisplatin and platinum(IV)chloride on cell growth, RNA, protein, ribosome and DNA synthesis in yeast

Hoffmann

1988

Toxicological & Environmental Chemistry

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The effect of cisplatin and platinum(IV)chloride on growth, RNA, ribosome, and DNA synthesis were tested in growing yeast cells. Treatment with both compounds causes comparable reduction but not a significant delay in the course of growth and RNA synthesis as well as DNA, and ribosome synthesis rates. The results were evaluated on the basis of a test system for rapid differentiation of nuclear and cytoplasmatic damage, which is founded on qualitative changes in growth curves and in synthesis rates. These observations indicate that PtCl 4 as well as cisplatin cause defects in the nuclear DNA. A quantitative comparison suggests that there exist differences in the nature of the DNA damage.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%