Investigation of Adipose Tissue Fatty Acid Composition in Men with Uronephrolithiasis and Metabolic Syndrome

Abstract

BackgroundFatty acids (FA) and their metabolites are closely related to some mechanisms involved in the development of uronephrolithiasis. The aim of this study was to evaluate the relationship between FA composition and type of kidney stones.Material/MethodsAbdominal adipose tissue fatty acid methyl esters of 71 men with nephrolithiasis were identified by GC/MS, and the type of kidney stones was identified using FTIR infrared spectroscopy. Patients were divided into groups according to diagnosis of metabolic syndrome (MS) and type of kidney stone. The composition of FA was compared within different groups of patients with different types of kidney stones and between the patients and healthy individuals (control group) (n=100).ResultsIndividuals with nephrolithiasis had a significantly higher level of monounsaturated fatty acids (MUFA) and a lower level of polyunsaturated fatty acids (PUFA) versus healthy individuals. Patients with MS had a higher level of 18: 1ω9 and a lower level of 16: 1ω7 than patients without MS. Individuals with nephrolithiasis, but without MS, had a higher level of saturated fatty acids (SFA) compared to controls. The level of PUFA was higher in the control group (p<0.0001) compared to individuals with uronephrolithiasis, with or without MS. PUFA, ω – 6 PUFA, and 18: 2ω6 were higher in patients with calcium-based kidney stones without MS versus patients with uric acid kidney stones with MS.ConclusionsThe levels of MUFA were significantly higher and the levels of PUFA were significantly lower in patients with uronephrolithiasis compared to controls.

Lipidomics Reveals the Therapeutic Effects of EtOAc Extract of Orthosiphon stamineus Benth. on Nephrolithiasis

“…Esterified fatty acids in glycerophospholipids are potential precursor for lipid mediators, especially ω-3 fatty acids ( Kang, 2012 ; Hishikawa et al, 2017 ). The concentration of ω-3 fatty acids in glycerophospholipids was obviously elevated in EEOS group mice than in model group, which is consistent with found that ω-3 fatty acids were significantly upper in normal people compared to patients with uronephrolithiasis ( Bikulčienė et al, 2018 ), indicating that EEOS extract may reduce the occurrence of kidney stones by regulating the ω-3 fatty acids metabolism.…”

“…Fatty acids metabolism is closely related to the formation of kidney stones ( Takahiro et al, 2008 ; Hall et al, 2017 ; Bikulčienė et al, 2018 ). Esterified fatty acids in glycerophospholipids are potential precursor for lipid mediators, especially ω-3 fatty acids ( Kang, 2012 ; Hishikawa et al, 2017 ).…”

Analytical methods used for the characterisation of specific features of biological tissues related with obesity: A review

“…The FTIR results of the studies [80,81] demonstrated that there were several alterations in the triglyceride spectral region of SAT and VAT of male obese mice. The authors [82] have used FTIR spectroscopy to investigate the composition of fatty acid of adipose tissue in men having the metabolic syndrome. The results from the patients with uronephrolithiasis differed from the results from the control group.…”