Investigation of anti-cancer activity of linear and aldehyde-activated levan from Halomonas smyrnensis AAD6T

Sarılmışer, Hande Kazak; Öner, Ebru Toksoy

doi:10.1016/j.bej.2014.06.020

Cited by 87 publications

(27 citation statements)

References 38 publications

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“…Levans represent an EPS group of β-(2→6)- D -fructans with some β-(2→1)-branches synthetized from sucrose by levansucrase, produced by several bacteria, including species of Bacillus , Zymomonas , Halomonas , Pseudomonas , Rahnella , Aerobacter , Erwinia , Streptococcus , Microbacterium ( Freitas et al, 2011a ; Esawy et al, 2012 ; Öner, 2013 ; Srikanth et al, 2015 ). The levan produced by a Halomonas smyrnensis strain, especially its oxidized (aldehyde) derivative, showed in vitro anti-cancer activity against human lung (A549), liver (Hep G2/C3A), gastric (AGS), breast (MCF-7) cancer cell lines ( Sarilmiser and Öner, 2014 ). Acetyl, phosphoryl, and benzyl esters of levan EPS, produced by a strain of Paenibacillus polymyxa , exhibited antioxidant and anti-proliferative activities against human gastric BGC-823 cancer cells in vitro ( Liu et al, 2012 ; Zong et al, 2012 ).…”

Section: Potential Applicationsmentioning

confidence: 99%

Present and future medical applications of microbial exopolysaccharides

2015

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Microbial exopolysaccharides (EPS) have found outstanding medical applications since the mid-20th century, with the first clinical trials on dextran solutions as plasma expanders. Other EPS entered medicine firstly as conventional pharmaceutical excipients (e.g., xanthan – as suspension stabilizer, or pullulan – in capsules and oral care products). Polysaccharides, initially obtained from plant or animal sources, became easily available for a wide range of applications, especially when they were commercially produced by microbial fermentation. Alginates are used as anti-reflux, dental impressions, or as matrix for tablets. Hyaluronic acid and derivatives are used in surgery, arthritis treatment, or wound healing. Bacterial cellulose is applied in wound dressings or scaffolds for tissue engineering. The development of drug controlled-release systems and of micro- and nanoparticulated ones, has opened a new era of medical applications for biopolymers. EPS and their derivatives are well-suited potentially non-toxic, biodegradable drug carriers. Such systems concern rating and targeting of controlled release. Their large area of applications is explained by the available manifold series of derivatives, whose useful properties can be thereby controlled. From matrix inclusion to conjugates, different systems have been designed to solubilize, and to assure stable transport in the body, target accumulation and variable rate-release of a drug substance. From controlled drug delivery, EPS potential applications expanded to vaccine adjuvants and diagnostic imaging systems. Other potential applications are related to the bioactive (immunomodulator, antitumor, antiviral) characteristics of EPS. The numerous potential applications still wait to be developed into commercial pharmaceuticals and medical devices. Based on previous and recent results in important medical-pharmaceutical domains, one can undoubtedly state that EPS medical applications have a broad future ahead.

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Section: Potential Applicationsmentioning

confidence: 99%

Present and future medical applications of microbial exopolysaccharides

2015

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“…In vitro anti-cancer activity of this linear levan and its oxidized forms containing increasing amounts of aldehydes in their structure were also investigated in human lung adenocarcinoma A549, human liver hepatocellular carcinoma HepG2/C3A, human gastric adenocarcinoma AGS, and human breast adenocarcinoma MCF-7 cell lines for the first time by our research group. Anti-cancer activity was found to depend on the dose as well as on the cell type and this effect became more apparent with the increasing degree of oxidation (14). Ternary blend films of chitosan, PEO and levan were also prepared to evaluate their morphological, thermo-mechanical, surface and biological properties (15).…”

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confidence: 99%

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Sarılmışer

Ateş

Ozdemir

et al. 2015

Journal of Bioscience and Bioengineering

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“…Algumas matrizes polissacarídicas, além de serem excelentes candidatos à isca, surgem como inovação terapêutica promissora, 163,164 a exemplo disso, tem-se a levana e seus derivados, [165][166][167][168][169] cuja utilização singular como antitumoral 170 ou combinada a quimioterápico à base de platina, 171 desencadeiam a apoptose de células tumorais, 60 podendo reduzir o perfil toxicológico de drogas quando utilizada em conjunto. 53,63 A levana consiste em homopolissacarídeo bacteriano, formado basicamente por unidades de frutose cujas ligações são do tipo (2→6) e com ramificações ocasionais do tipo (2→1).…”

Section: Anzolunclassified

Antineoplastic Chemotherapics Platinum-Based Under the Light of Evolutionary Biology

Silva

Belian

2018

Rev. Virtual Quim.

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The platinum-based coordination compounds consist of an important class of antineoplastic chemotherapeutics with a view to their worldwide commercialization. Even cisplatin being officially approved in 1978 by the FDA, Cairns (in 1975) and Nowell (1976) had already postulated the emergence of drug-resistant tumor cells via somatic evolution; i.e., the need for reflection on Darwinian dynamics was already known. The evolutionary adaptations of cancer must be known in order to avoid the arise of the multidrug resistance phenomenon (MDR), whose phenotypic expressions may include processes such as angiogenesis, inflammatory lesions, oxidative metabolism and ultra-expression of telomerase, acquired during the stages of carcinogenesis. In this paper, we discuss the platinum composition and a view of evolutionary biology in the design of new platinum-drugs antineoplastic influenced by what we call of the "Bait-Hook principle".

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Investigation of anti-cancer activity of linear and aldehyde-activated levan from Halomonas smyrnensis AAD6T

Cited by 87 publications

References 38 publications

Present and future medical applications of microbial exopolysaccharides

Present and future medical applications of microbial exopolysaccharides

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

Antineoplastic Chemotherapics Platinum-Based Under the Light of Evolutionary Biology

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