The synthesis of C-glycosides, sugar analogs in which glycosidic oxygen is substituted by a carbon atom, is of particular interest due to their usefulness as key intermediates for assembling biologically active molecules and natural products. Despite their challenging chemistry, due to their versatility, C-glycosides play a pivotal role in the development of the chemistry of novel materials and bioactive molecules. In this review, we present of various synthetic methodologies, mechanistic proposal and application for 2,3-unsaturated C-glycosides in the last twenty years.

The platinum-based coordination compounds consist of an important class of antineoplastic chemotherapeutics with a view to their worldwide commercialization. Even cisplatin being officially approved in 1978 by the FDA, Cairns (in 1975) and Nowell (1976) had already postulated the emergence of drug-resistant tumor cells via somatic evolution; i.e., the need for reflection on Darwinian dynamics was already known. The evolutionary adaptations of cancer must be known in order to avoid the arise of the multidrug resistance phenomenon (MDR), whose phenotypic expressions may include processes such as angiogenesis, inflammatory lesions, oxidative metabolism and ultra-expression of telomerase, acquired during the stages of carcinogenesis. In this paper, we discuss the platinum composition and a view of evolutionary biology in the design of new platinum-drugs antineoplastic influenced by what we call of the "Bait-Hook principle".

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