Investigation of antimicrobial activity of photothermal therapeutic gold/copper sulfide core/shell nanoparticles to bacterial spores and cells

Addae, Ebenezer; Dong, Xiuli; McCoy, Eric; Yang, Chang; Chen, Wei; Yang, Liju

doi:10.1186/1754-1611-8-11

Cited by 44 publications

(23 citation statements)

References 40 publications

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“…One of the mechanisms of NP-antimicrobial actions is cell wall lysis. For example, a study by Addae et al [ 12 ] in an attempt to produce a transducer agent for photothermal therapy (PTT) found the destruction of Bacillus species cell membranes when treated with Au/CuS NPs. The destruction of Bacillus species in this study proved that Au/CuS NPs are potent NP-antimicrobial agents.…”

Section: Broad Spectrum Nanoparticle-antimicrobial Agentsmentioning

confidence: 99%

“… B. anthracis spores and cells The Au/CuS NPs were highly efficient in inactivating B. anthracis cells, but not effective to the spores. ND [ 12 ] Sialic-acid functionalized gold nanoparticles TEM 2 nm and 14 nm Influenza virus The NPs inhibition influenza virus infection The functionalized AuNPs were nontoxic to the cells [ 107 ] Titanium dioxide nanoparticles (TiO2 NPs) XRD, FTIR, SEM, EDX, AFM. Average size of 70 nm.…”

Section: Broad Spectrum Nanoparticle-antimicrobial Agentsmentioning

confidence: 99%

“…The NPs physiochemical properties are highly diverse in nature and are highly applicable in biomedical field including antimicrobial and drug delivery [ 6 , 8 , 9 ]. Some examples of these biomedical NPs include silver nanoparticles (AgNPs) [ 10 ], carbon nanotubes (CNTs) [ 11 ], gold NPs (AuNPs) [ 12 ], zinc oxide NPs (ZnO-NPs) [ 13 ], and iron oxide NPs (FeO-NPs) [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Nanoparticles as potential new generation broad spectrum antimicrobial agents

2015

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The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting treatment of intracellular pathogens. Therefore, the disease-causing-organisms tend to persist in these cells. However, the emergence of nanoparticle (NP) technology has come with the promising broad spectrum NP-antimicrobial agents due to their vast physiochemical and functionalization properties. In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens. Indeed, the perspective of developing potent NP-antimicrobial agents that carry multiple-functionality will revolutionize clinical medicine and play a significant role in alleviating disease burden.

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Section: Broad Spectrum Nanoparticle-antimicrobial Agentsmentioning

confidence: 99%

Section: Broad Spectrum Nanoparticle-antimicrobial Agentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanoparticles as potential new generation broad spectrum antimicrobial agents

2015

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“…AuNPs have optical absorption in the near-infrared region and can destroy bacteria via photothermal heating [79]. AuNPs generate holes in the cell wall, resulting in the leakage of cell contents and cell death.…”

Section: Topical Applications Of Nanoparticlesmentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

454

227

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This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

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“…Gold-copper sulfide (Au-CuS) core-shell nanoparticles demonstrated extreme capability to deactivate B. anthracis cells by disordering and damaging its cell membrane; furthermore, antibacterial activity depends on nanoparticle concentration and treatment time [68]. The antimicrobial activity of nanoparticles and microbial cell death can be related to the electrostatic interaction between negatively charged bacterial cells and positively charged nanoparticles which stimulates the loss of membrane integrity [69].…”

Section: Antibacterial Activity Of Core-shell Nanoparticlesmentioning

confidence: 99%

Complications of Antibiotic Therapy and Introduction of Nanoantibiotics

Lasemi¹,

Navi²,

Lasemi³

et al. 2016

A Textbook of Advanced Oral and Maxillofacial Surgery Volume 3

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Oral and maxillofacial surgeons play a major role in therapy, preventing morbidity, mortality from odontogenic and non-odontogenic maxillofacial infections therefore, it is essential to have knowledge of current advancements in microbiological diagnosis and antibiotic therapy for odontogenic maxillofacial infections. Fortunately, we live in an era where antibiotics are readily available to prevent and treat against infections. The exact cause should be determined once the specific antibiotic is prescribed additionally, the empirical, definitive treatments, side effects, pharmacokinetics and pharmacodynamics of antibacterial agents have to be considered.Nowadays, antimicrobial resistance which is spreading rapidly is of great concern, because it is common in hospitals where acquired infections can be perilous. This situation compels scientists to synthesize new antibiotics and treatment modalities. The reason of microbial resistance can be due to increased misuse of antibiotics in foods livestock, poultry and agriculture . " number of significant factors, such as organism identification, antibiotic sensitivity testing and host factor situations, should be taken into account in order to treat various infections effectively.Currently, investigations are ongoing to impede antibacterial resistance by nanoscience technology seeking new chemotherapeutic agents. Scientists focusing on microbiological investigations aim to invent novel nanoantibiotic agents with high efficiency, low toxicity and low percentage of resistance. In recent years, nanoantibiotics have been applied against infections intelligently. The average size, polydispersity and composition of generated nanomaterials can be controlled by various methods in order to make them appropriate for biomedical applications.

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Investigation of antimicrobial activity of photothermal therapeutic gold/copper sulfide core/shell nanoparticles to bacterial spores and cells

Cited by 44 publications

References 40 publications

Nanoparticles as potential new generation broad spectrum antimicrobial agents

Nanoparticles as potential new generation broad spectrum antimicrobial agents

Nanoparticles and nanofibers for topical drug delivery

Complications of Antibiotic Therapy and Introduction of Nanoantibiotics

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