Investigation of Antiphosphatidyl‐Serine Antibody and Antiphosphatidyl‐Inositol Antibody in Ischemic Stroke Patients

Abstract

Antiphospholipid syndrome is characterized by arterial or venous thrombosis and the presence of antiphospholipid antibodies (aPL). We measured β2-GPI aCL, IgGaCL, LA, antiphosphatidyl-serine antibody (PS), and antiphosphatidyl-inositol antibody (PI) in each patient at one month after the onset of stroke. In addition, carotid artery echography was performed in patients positive for PI or PS. Among the 250 patients, 13.6% (34/250) were positive for either PI or PS, and 6.8% (17/250) were positive for both. Carotid artery echography performed on these 34 patients showed that the frequencies of increased intimal-medial thickness (IMT) of 1.1 mm or more, plaque, and carotid artery stenosis of 50% or more were all significantly higher in patients positive for antinuclear antibody than those negative for the antibody (P < .05). PI and PS are associated with antinuclear antibody and precipitation of atherosclerosis. Ischemic stroke patients with SLE frequently showed a variety of antiphospholipid-protein antibodies.

Antiphosphatidylserine antibodies as diagnostic indicators of antiphospholipid syndrome

“…Moreover, recent data support an association between aPS and pathogenesis of thrombosis. 8,18,27 Thrombosis and recurrent pregnancy loss are the main clinical presentations in the Sapporo criteria. Our results showed that 47.6% and 52% of patients with thrombosis and recurrent pregnancy failure, respectively, had a positive result for aPS.…”

“…[10][11][12][13][14][15][16][17] The clinical significance of other autoantibodies, including those directed against prothrombin, annexin, phosphatidylinositol and phosphatidylserine (PS), is still undetermined. 4,18,19 Recent studies suggested some association between these autoantibodies and the clinical features of APS. 3,20 Adler et al 21,22 found that autoantibodies against PS could interfere with the normal formation of syncytiotrophoblast, thus affecting placental development.…”

“…3,[23][24][25][26] Other studies showed an association between aPS and thrombosis and atherosclerosis. 8,18,27 The diagnosis of APS is complicated by ongoing debates, particularly those regarding the type of laboratory tests that should be used for classification of the syndrome. 3,7,28,29 The aim of this study was to determine the diagnostic value of aPS testing in APS, and to compare this to the values found for aPL antibodies included in the Sapporo criteria.…”

Antiphospholipid Antibodies and Their Association with Atherosclerotic Changes in Patients with Systemic Lupus Erythematosus – Review of Literature and Own Experiences

“…On the other hand, 70.6% of these patients were positive for antinuclear antibodies. The authors pointed out that aPL are a risk factor for cerebral infarction especially in SLE patients and in younger population (Okuma et al, 2010). Moreover, a significant association between CIMT and the risk of ischemic stroke has been well documented (Chambless et al, 2000;Touboul et al, 2005).…”

Antiphosphatidylserine Antibody as a Cause of Multiple Dural Venous Sinus Thromboses and ST-Elevation Myocardial Infarction

“…Antiphospholipid syndrome (APS) is an acquired autoimmune disorder that results in a hypercoagulable state characterized by recurrent venous and/or arterial thrombosis [ 1 ]. Antiphospholipid antibodies are directed against proteins that bind to anionic phospholipids on plasma membranes [ 2 ].…”