Investigation of Antituberculosis from Medicinal Plant of Community Ethnic in South Sulawesi

Abstract

Aims: The aim of this research was to know the species of plant that is used as anti-hematemesis medicine that has the activity of antituberculosis and antituberculosis-MDR and then investigate the phytochemistry characteristics of the compound from every parts of the plant extract that show the activity of antituberculosis and antituberculosis-MDR which is indicated by the value of Minimum Inhibitory Concentration (MIC) of the exctracts. Background: Tuberculosis is one of the transmitted disease that has been claimed as one of the serious health problem in the world that can cause death as reported in WHO in Global Tuberculosis Report 2014. It has been predicted that 9 million of people suffers tuberculosis disease and 1.5 - 2 million people has dead by this disease. Objective: Discovery of antituberculosis and antituberculosis MDR agent from medicinal plant of communtity ethnis in south sulawesimethodThe extraction method used in this research was maceration method. The antituberculosis activity test was investigated using MODS and LJ methods. The isolation of the active compound was carried out using Bioassay Guided Fractination and then the compound characteristics were identified using spectroscopy data. Result: The results showed that extracts from Talas and Kariango plants were active against M. tuberculosis. The FTIR data showed that three isolates obtained from Talas plants contained aliphatic OH and C-O and CH groups. The MIC values of kariango and Talas extracts using the MODS method were 45 mg / ml and 40 mg / ml, respectively. Conclusion: Talas (Collocasia esculenta) tuber and Kariango rhizome ethanolic extract have a potency for antituberculosis and anti-MDR tuberculosis drug.